Anti-Inflammatory Effects of Physical Exercise on Obesity

Figueiredo, Lídia; Nunes, Ramiro Barcos; Marmett, Bruna; Sá, Larissa Bianca Paiva Cunha de; Arbex, Alberto Krayyem

doi:10.4236/ojemd.2017.71005

Cited by 7 publications

(6 citation statements)

References 12 publications

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“…Therefore, discovering new alternatives to prevent the accumulation of visceral fat and mobilization of adipokines is of the utmost importance when modulating energy homeostasis and insulin sensitivity. Studies have shown that aerobic or anaerobic exercises may be effective (Zanuso et al, 2010) in the treatment of obesity (Figueiredo et al, 2017) and diabetes (Plomgaard and Weigert, 2017). Exercise promotes increases in the systemic levels of anti-inflammatory cytokines such as Interleukin-4 (IL-4), Interleukin (IL-10) (Balducci et al, 2010) and adiponectin (Miyazaki et al, 2010), and stimulates the C-X-C motif chemokine ligand 8 (CXCL8), a cytokine that acts as an angiogenic factor in human microvascular endothelial cells (Ostrowski et al, 2001), and is associated with insulin resistance and obesity (Bruun et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Exercise and Omentin: Their Role in the Crosstalk Between Muscle and Adipose Tissues in Type 2 Diabetes Mellitus Rat Models

et al. 2019

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This study aims to analyze the effects of resisted, aerobic, and combined exercises on omentin levels in visceral adipose tissue and muscle of rats with experimental diabetes to verify whether these adipokines are related to the glucose pathway and inflammation process in this model. Male Wistar rats received a high-fat diet for 4 weeks and a low dose of streptozotocin (35 mg/kg) to induce experimental diabetes. After inducing diabetes, the animals were divided into 4 experimental groups (n = 10): diabetic control (C); resistance training (RT); aerobic training (AT); and combined training (CT). The groups were exercised for 12 weeks, 3 times/week, where: RT means the stair climbing protocol until exhaustion; AT is the 30 min/day reaching 20 m/min protocol, and CT is the combination of RT and AT. The AT group showed reduced retroperitoneal and mesenteric adipose tissue and abdominal fat deposits. Our study also showed a possible control of blood glucose, as well as decreased Interleukin 6 (IL-6) and C-reactive protein, increased circulating adiponectin and increased omentin in visceral adipose tissue. In addition, the AT group affected the glucose pathway by stimulating phosphorylation of Akt in muscle tissue. Omentin also showed a strong positive correlation with adiponectin and a moderate negative correlation with IL-6. Thus, our findings indicated that omentin in type 2 diabetes is changed by AT. Furthermore, increased omentin levels had a close association with the glucose pathway by stimulating phosphorylation of Akt in muscle tissue and with IL-6 in serum, suggesting that omentin is likely to have anti-inflammatory and protective action in experimental diabetes.

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Section: Introductionmentioning

confidence: 99%

Exercise and Omentin: Their Role in the Crosstalk Between Muscle and Adipose Tissues in Type 2 Diabetes Mellitus Rat Models

et al. 2019

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“…In addition to increasing physical fitness, a recent metareview suggested that aerobic and resistance exercises with moderate intensity are able to reduce the inflammatory biomarkers CRP, IL-6, and tumor necrosis factor-α in blood 38 . Low to moderate intensive aerobic exercise is also effective in reducing inflammation and improves metabolic markers in individuals with obesity and metabolic syndrome 39 . A comprehensive exercise guideline for cancer survivors to improve physical fitness and health-related quality-of-life has been published recently 40 and may be adapted to improve their current status.…”

Section: Discussionmentioning

confidence: 99%

Physical Inactivity as an Early Sign of Frailty in Young Adult Survivors of Childhood Acute Lymphoblastic Leukemia

Chua

Azanan

et al. 2022

Journal of Pediatric Hematology/Oncology

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Young adult survivors of childhood leukemia have been reported with increased likelihood of age-related comorbidities compared with the general population. We compared the prevalence of frailty in young adult survivors of childhood acute lymphoblastic leukemia (n=58, median age=23 y, median survival time=18 y) with age-matched and sex-matched controls without history of cancer. Frailty phenotypes were determined using Fried frailty model. Association between frailty status and cardiometabolic conditions, systemic inflammation, and T-cell immunophenotype changes were also examined. Frailty and prefrailty were more common among survivors compared with controls (58.6% vs. 34.5%, P=0.019). Physical inactivity (39.7%) was the most frequently observed frailty criterion among the survivors. Prevalence of cardiometabolic conditions was comparable between the robust and frail/prefrail survivors. Robust survivors had a higher level of T-cell activation than the prefrail/frail survivors (P<0.05), but no significant difference was observed for systemic inflammatory markers (IL-6 and C-reactive protein) and percentage of terminally differentiated T cells. Signs of frailty, especially physical inactivity, was detected in childhood acute lymphoblastic leukemia survivors early in their third decade of life. Survivors who were prefrail/frail also had altered T-cell activation; however, the role of such changes in T-cell phenotype in the etiology of frailty warrant further investigation.

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“…Even with this slight inflammatory activation caused by the diet, it is noteworthy that HIIT in obese animals reduced the levels of IL-6, IL-10, and adiponectin. It is known that the stress promoted by physical exercise is linked to an increase in catecholamine discharge and that the catecholamine receptors present in macrophages have great importance in modulating the inflammatory response (Figueiredo et al, 2017). In the condition of obesity, a high-fat diet could lead to an increase in catecholamines, which, in turn, via cAMP response elementbinding protein, would suppress the expression of adiponectin (Liu and Liu, 2009).…”

Section: Discussionmentioning

confidence: 99%

High-Intensity Interval Training Does Not Change Vaspin and Omentin and Does Not Reduce Visceral Adipose Tissue in Obese Rats

et al. 2021

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This study aimed to determine the expression of omentin and vaspin, inflammatory markers, body composition, and lipid profile in diet-induced obese rats and high-intensity interval training (HIIT). Forty Wistar rats were divided into four groups: untrained normal diet, trained normal diet (T-ND), untrained high-fat diet (Unt-HFD), and trained high-fat diet (T-HFD). For the animals of the Unt-HFD and T-HFD groups, a high-fat diet was offered for 4 weeks. After that, all the animals in the T-ND and T-HFD groups were submitted to HITT, three times per week, for 10 weeks (2 weeks of adaptation and 8 weeks of HIIT). Muscle (gastrocnemius), liver, epididymal adipose tissue, retroperitoneal adipose tissue, visceral adipose tissue (VAT), and serum were collected to analyze TNF-α, IL-6, PCR, IL-8, IL-10, IL-4, vaspin, and omentin. A body composition analysis was performed before adaptation to HIIT protocol and after the last exercise session using dual-energy X-ray absorptiometry. Omentin and vaspin in the VAT were quantified using Western blotting. The results showed that, when fed a high-fat diet, the animals obtained significant gains in body fat and elevated serum concentrations of vaspin and blood triglycerides. The HIIT was able to minimize body fat gain but did not reduce visceral fat despite the increase in maximum exercise capacity. Moreover, there was a reduction in the serum levels of adiponectin, IL-6, and IL-10. Finally, we concluded that, although the training protocol was able to slow down the weight gain of the animals, there was no reduction in visceral fat or an improvement in the inflammatory profile, including no changes in omentin and vaspin.

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Anti-Inflammatory Effects of Physical Exercise on Obesity

Cited by 7 publications

References 12 publications

Exercise and Omentin: Their Role in the Crosstalk Between Muscle and Adipose Tissues in Type 2 Diabetes Mellitus Rat Models

Exercise and Omentin: Their Role in the Crosstalk Between Muscle and Adipose Tissues in Type 2 Diabetes Mellitus Rat Models

Physical Inactivity as an Early Sign of Frailty in Young Adult Survivors of Childhood Acute Lymphoblastic Leukemia

High-Intensity Interval Training Does Not Change Vaspin and Omentin and Does Not Reduce Visceral Adipose Tissue in Obese Rats

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