Anti-inflammatory effects of pentoxifylline

Groesdonk, HV; Heringlake, Matthias; Heinze, Hermann

doi:10.1007/s00101-009-1626-9

Cited by 6 publications

(1 citation statement)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PTX exhibits potent anti-inflammatory effects [31, 32], directly inhibits TNFα, and reduces inflammation in multiple preclinical models [33–35], chemotherapy-induced intestinal (CPT-11) and oral (5-FU) mucositis [36, 37]. In combination with daily fractionated irradiation, PTX had significant effects on TNFα and IL-1β, but no effect on the mutual downstream protein NF-κB.…”

Section: Discussionmentioning

confidence: 99%

Early inflammatory changes in radiation-induced oral mucositis

Gruber¹,

Bozsaky²,

Roitinger³

et al. 2017

Strahlenther Onkol

View full text Add to dashboard Cite

PurposeEarly inflammation is a major factor of mucosal reactions to radiotherapy. Pentoxifylline administration resulted in a significant amelioration of radiation-induced oral mucositis in the mouse tongue model. The underlying mechanisms may be related to the immunomodulatory properties of the drug. The present study hence focuses on the manifestation of early inflammatory changes in mouse tongue during daily fractionated irradiation and their potential modulation by pentoxifylline.Materials and methodsDaily fractionated irradiation with 5 fractions of 3 Gy/week (days 0–4, 7–11) was given to the snouts of mice. Groups of 3 animals per day were euthanized every second day between day 0 and 14. Pentoxifylline (15 mg/kg, s. c.) was administered daily from day 5 to the day before sacrifice. The expression of the inflammatory proteins TNFα, NF-κB, and IL-1β were analysed.ResultsFractionated irradiation increased the expression of all inflammatory markers. Pentoxifylline significantly reduced the expression of TNFα and IL-1β, but not NF-κB.ConclusionEarly inflammation, as indicated by the expression of the inflammatory markers TNFα, NF-κB, and IL-1β, is an essential component of early radiogenic oral mucositis. Pentoxifylline differentially modulated the expression of different inflammatory markers. The mucoprotective effect of pentoxifylline does not appear to be based on modulation of NF-κB-associated inflammation.

show abstract

Section: Discussionmentioning

confidence: 99%

Early inflammatory changes in radiation-induced oral mucositis

Gruber¹,

Bozsaky²,

Roitinger³

et al. 2017

Strahlenther Onkol

View full text Add to dashboard Cite

show abstract

In vivo effects of pentoxifylline on enzyme and non‐enzyme antioxidant levels in rat liver after carrageenan‐induced paw inflammation

Vircheva

Alexandrova

Georgieva

et al. 2010

Cell Biochemistry & Function

View full text Add to dashboard Cite

The present study aimed to investigate the effects of pentoxifylline (PTX) on the carrageenan (CG)-induced paw oedema and on the endogenous levels of cell enzyme and non-enzyme antioxidants in rat liver, 4 and 24 h after CG injection. PTX (50 mg kg(-1) , i.p.), administered 30 min before CG, decreased the paw oedema, 2-4 h after CG administration. The drug protected CG-induced decrease of glutathione (non-enzyme antioxidant) and had no effect on CG-unchanged activities of superoxide dismutase, glutathione peroxidase (enzyme antioxidants) and glucose-6-phosphate dehydrogenase (enzyme, important for the activity of GSH-conjugated antioxidant enzymes). The drug showed a good antioxidant capacity in chemical systems, generating reactive oxygen species. The present results suggest that the antioxidant activity of PTX might contribute to its beneficial effects in liver injuries.

show abstract

A histological study on the effect of pentoxifylline on acute lung injury induced by renal ischemia–reperfusion

Makhlouf

Saleh

2014

The Egyptian Journal of Histology

View full text Add to dashboard Cite

Pentoxifylline (PTX) is a methylxanthine derivative that improves blood flow by decreasing its viscosity. Recently, PTX was proven to be an antioxidant [7], an inhibitor of inflammatory cytokines [8], and a phosphodiesterase inhibitor [9]. BackgroundKidney ischemia-reperfusion injury (IRI) occurs under many clinical conditions. It leads to acute kidney injury, which may affect various remote but important organs such as the lung. Aim of the workThe aim of the present study was to investigate the effect of renal IRI on the lung structure and evaluate the possible protective effect of pentoxifylline (PTX). Materials and MethodsFifteen adult male Wistar rats aged 8-10 weeks and weighing 150-200 g were used in this study. They were divided into the following groups: group I (the control group) was subjected to sham operation; group II (the IRI group) was subjected to renal ischemia by bilateral clamping of the renal pedicles for 45 min and then allowed 24 h of reperfusion. Group III (the PTX-treated group) was given two doses of PTX (40 mg/kg) intraperitoneally and subjected to an ischemia-reperfusion procedure as performed in group II. Lung specimens were processed for light and electron microscopic examination. The mean thickness of the interalveolar septa and the mean number of type-II pneumocytes were measured. ResultsGroup II showed diffuse lung injury affecting mainly the alveoli, which appeared flooded with exudate and red blood cells, which also extravasated in the interstitium. There was vacuolation of the cytoplasm of both type-I and type-II pneumocytes with significant increase in the number of type-II cells and depletion of lamellar bodies. Significant increase in the mean thickness of the interalveolar septa was detected and it showed infiltration by macrophages and neutrophils. PTX caused marked improvement in the lung structure after ischemia-reperfusion. Most of the alveoli appeared empty and a few of them showed minimal red blood cells and macrophages. Thin interalveolar septa were detected with thickness comparable to that of the control group. ConclusionRenal IRI caused alteration in the lung structure, which was ameliorated by PTX administration.

show abstract

Anti-inflammatory effects of pentoxifylline

Cited by 6 publications

References 52 publications

Early inflammatory changes in radiation-induced oral mucositis

Early inflammatory changes in radiation-induced oral mucositis

In vivo effects of pentoxifylline on enzyme and non‐enzyme antioxidant levels in rat liver after carrageenan‐induced paw inflammation

A histological study on the effect of pentoxifylline on acute lung injury induced by renal ischemia–reperfusion

Contact Info

Product

Resources

About