Anti-inflammatory effects of N-Acetylcysteine and Elaeagnus angustifolia extract on acute lung injury induced by λ-carrageenan in rat

Abstract

N -Acetylcysteine (NAC) is a chemical compound with anti-inflammatory and antioxidant activity and acts as a free radical scavenger. Elaeagnus angustifolia (EA) is a plant native to the western part of Iran, with antioxidant and anti-inflammatory properties. The present study been taken evaluated the protective effect afforded by EA and NAC extracts on carrageenan-induced acute lung injury in Wistar rats. In this study, 42 rats were randomly assigned into seven groups. NAC and EA extracts were orally administered once/day for 21 continuous days. Pulmonary damage was induced by intratracheal injection of 100 μl of 2% λ-Carrageenan on day 21. Twenty-four hours post-surgery, the rats were euthanized and the samples were collected. Pretreatment with NAC and EA extracts reduced the total and differential cell accumulation as well as IL-6, and TNF-α cytokines. Antioxidant indicators demonstrate that in the groups receiving NAC and EA extract, MDA decreased while thiol and antioxidant capacity elevated. Treatment with NAC and EA significantly reduced Carrageenan-induced pathological pulmonary tissue injury. NAC and EA extract has protective effects on acute carrageenan-induced lung injury.

Effectiveness of N-Acetylcysteine on Zinc oxide Nanoparticles-Induced Cardiotoxicity in Adult Albino Rats

“…Thiol suppliers such as NAC could be used to down regulate apoptosis in different cell models. Additionally, NAC has been shown to be an antigenotoxic agent by its antioxidant properties as it can decrease cytogenetical damage and mutagenic agents' effects (Mamashli et al, 2022) In the histopathological examination, ZnO NPs induced several alterations in ZnO NPs group as compared to control group and (ZnO NPs &NAC) group, evidenced by disorganization and degeneration of the myocardium, congestion in myocardial blood vessels with thrombus formation. These results were supported by Nemenqani, (2015) who observed severe myocardial necrosis with subendocardial loss of heart muscles in ZnO NPs administered rats in a two weeks study using a dose 1 g/kg BW once daily via oral route.…”

Exploring Elaeagnus Angustifolia: A Comprehensive Review of its Potential in Cancer Treatment and Management

“…The plant's interactions with cancer cells include the modulation of various signalling pathways that are dysregulated in cancer. Notably, EA has been shown to affect pathways such as PI3K/AKT [42], MAPK/ERK [42], and NF-κB [43], which play critical roles in cancer development and progression ] 46 -44 [ . In addition, EA extracts have demonstrated anti-angiogenic effects by inhibiting the production of pro-angiogenic factors, such as VEGF [37].…”

“…Potential Therapeutic Implications References PI3K/AKT Pathway -Inhibition of cancer cell survival and proliferation [42] MAPK/ERK Pathway -Impact on cancer cell growth and survival [42] NF-κB Pathway -Potential anti-inflammatory and anti-cancer effects [43] Apoptotic Pathways -Induction of programmed cell death in cancer cells [20][21][22] Angiogenesis Pathways -Inhibition of new blood vessel formation for restricting tumour growth [37]…”