Anti-inflammatory effects of low-dose radiotherapy in an experimental model of systemic inflammation in mice

Arenas, Meritxell; Gil, Félix; Gironella, Meritxell; Hernández, Víctor; Jorcano, S.; Biete, Albert; Piqué, Josep M.; Panés, Julián

doi:10.1016/j.ijrobp.2006.06.004

Cited by 75 publications

(54 citation statements)

References 34 publications

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“…Neutralization TGF-β1 with specific antibodies restored the adhesion between PBMC and EC. These in vitro results were confirmed in vivo in a mouse model for 0.3 Gy [15]. TGF-β expression is dependent on activation of the nuclear factor-kappa B (NF-κB) [16].…”

mentioning

confidence: 65%

Low-Dose Radiotherapy of Painful Heel Spur/Plantar Fasciitis as an Example of Treatment Effects in Benign Diseases

Hermann¹,

Bruns²,

Nitsche³

2017

Radiotherapy

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Degenerative changes in the plantar fascia may cause the so-called "painful heel" with typical projections of tenderness. This condition is often associated with a plantar heel spur. Radiotherapy with low doses (LD-EBRT) has been well known for its anti-inflammatory potential. In the recent years, several microbiological mechanisms were elucidated to explain immunomodulation by LD-EBRT. Furthermore, a randomized study proved the clinical efficacy of this therapy in plantar fasciitis. Two other trials defined a fractionation schedule of 6 × 0.5 Gy twice weekly as the new standard therapy. Taken together, LD-EBRT is an effective and safe therapeutic option for patients over 30 years of age and after exclusion of pregnancy. In case of an insufficient response, a second course can be offered to the patient. There are still open questions concerning target volume definition and fractionation of LD-EBRT. Furthermore, studies randomizing LD-EBRT with other conservative therapeutic approaches are missing.

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mentioning

confidence: 65%

Low-Dose Radiotherapy of Painful Heel Spur/Plantar Fasciitis as an Example of Treatment Effects in Benign Diseases

Hermann¹,

Bruns²,

Nitsche³

2017

Radiotherapy

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“…This characteristic functionally coincides with nonlinear expression of the anti-inflammatory cytokine transforming growth factor β1 (TGF-β1) by EC, both in vitro and in a murine model. Likewise, neutralization of TGF-β1 restored leucocyte/EC adhesion, indicating a key role of the protein in these effects [3,53].…”

Section: Modulatory Properties On Endothelial Cellsmentioning

confidence: 91%

DEGRO practical guidelines for radiotherapy of non-malignant disorders

Reichl

Block²,

Schäfer

et al. 2015

Strahlenther Onkol

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“…The data of health examination showed radiation can induce calcification of aortic arch, a rise in systolic and diastolic blood pressure [29] and serum cholesterol levels [30], and has dose effect relation to some extent [31]. Whole-body doses of rats from 0.1-0.6 Gy inhibited leukocyte adhesion to endothelial cells [32], and doses from 0.025-0.05 Gy manifested protective effects on the development of atherosclerosis in ApoE knockout mice, especially at low dose rates [33]. It suggested that an non-liner dose-response relationship existed between radiation and atherosclerosis, that is also to say a protective effect on cardiovascular in very-low-dose occupational exposures (0.02 Sv), but detrimental effects in higher doses (0.2 Sv) in epidemiological researches [34].…”

Section: Molecular Mechanismsmentioning

confidence: 99%

Low Dose Radiation Exposure and Cardiovascular Diseases: A Review

Gao

Ding

2017

ijcp

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The International Commission on Radiological Protection (ICRP) states that particular attention should be paid to radiation effects on the cardiovascular system because of recent published observations of their effects occurring at lower doses than previously reported (ICRP, 2007 and2012). The review was based on scientific articles available in open literature and major reviews by organizations, in particular ICRP118. In this review, we describe the low-dose ionizing radiation effects, the causes of cardiovascular diseases (CVDs), the relationship between low-dose ionizing radiation and CVDs, and the importance of elucidating the relationship between low-dose ionizing radiation and CVD.

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Anti-inflammatory effects of low-dose radiotherapy in an experimental model of systemic inflammation in mice

Cited by 75 publications

References 34 publications

Low-Dose Radiotherapy of Painful Heel Spur/Plantar Fasciitis as an Example of Treatment Effects in Benign Diseases

Low-Dose Radiotherapy of Painful Heel Spur/Plantar Fasciitis as an Example of Treatment Effects in Benign Diseases

DEGRO practical guidelines for radiotherapy of non-malignant disorders

Low Dose Radiation Exposure and Cardiovascular Diseases: A Review

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