Anti-inflammatory effects of Lactobacillus reuteri
                    LM1071 via MAP kinase pathway in IL-1β-induced HT-29
                    cells

Kim, Tae-Rahk; Choi, Kyoung‐Sook; Ji, Yosep; Holzapfel, Wilhelm H.; Jeon, Min-Gyu

doi:10.5187/jast.2020.62.6.864

Cited by 13 publications

(16 citation statements)

References 43 publications

(52 reference statements)

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“…Similarly, it has been reported that L . reuteri can decrease mRNA expression levels of IL ‐ 6 , TNF ‐ α and IL ‐ 4 in IL‐1β‐induced HT‐29 cells (Kim et al, 2020). Conversely, treatment with various concentrations of L .…”

Section: Discussionmentioning

confidence: 99%

“…L . reuteri LM1071 was obtained from LACTOMASON at a concentration of 4.8 × 10 9 cells g −1 (Kim et al, 2020). L .…”

Section: Methodsmentioning

confidence: 99%

“…L. reuteri LM1071 was obtained from LACTOMASON at a concentration of 4.8 × 10 9 cells g −1 (Kim et al, 2020). L. reuteri LM1071 was prepared in stock solution at 1 mg ml −1 (w/v) that dissolved in dimethyl sulfoxide (DMSO), and diluted various concentrations using culture medium for experiment.…”

Section: Lactic Acid Bacteria Strainmentioning

confidence: 99%

“…Recently, it has been reported that L . reuteri LM1071 isolated from human breast milk exhibits anti‐inflammatory effects on mRNA expression of IL ‐ 6 , TNF ‐ α and IL ‐ 4 in IL‐1β‐stimulated HT‐29 cells and that it can be used as an effective and safe probiotic for humans (Kim et al, 2020). However, anti‐inflammatory effects of L .…”

Section: Introductionmentioning

confidence: 99%

“…L. reuteri DSM12246 can suppress the production of IL-12, IL-6 and TNF-α in dendritic cells of mice (Christensen et al, 2002). Recently, it has been reported that L. reuteri LM1071 isolated from human breast milk exhibits anti-inflammatory effects on mRNA expression of IL-6, TNFα and IL-4 in IL-1β-stimulated HT-29 cells and that it can be used as an effective and safe probiotic for humans (Kim et al, 2020). However, antiinflammatory effects of L. reuteri based on the evidence of eicosanoid production have not been reported yet.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Anti-inflammatory potential of Lactobacillus reuteri LM1071 via eicosanoid regulation in LPS-stimulated RAW264.7 cells

Jang

Rod-in

Monmai

et al. 2022

Journal of Applied Microbiology

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Aims To investigate anti‐inflammatory effects of Lactobacillus reuteri LM1071 in lipopolysaccharides (LPS)‐induced inflammation RAW264.7 cells. Methods and Results To evaluate anti‐inflammatory activities of L. reuteri LM1071, LPS‐stimulated RAW264.7 cells were used. Gene expression levels of eight immune‐associated genes including IL‐1β, IL‐6 and TNF‐α and protein production levels of COX‐1 and COX‐2 were analysed. Moreover, the production of eicosanoids as important biomarkers for anti‐inflammation was determined. Conclusions The current study demonstrates that L. reuteri LM1071 has anti‐inflammatory potential by inhibiting the production of inflammation mediators such as NO, eicosanoids such as PGE1 & PGE2, pro‐inflammatory cytokines and COX proteins. It can also enhance the production of inflammatory associated genes such as IL‐11, BMP4, LEFTY2 and EET metabolite. Significance and Impact of the Study Lactobacillus reuteri is one of the crucial bacteria for food fermentation. It can be found in the gastrointestinal system of human and animals. Several studies have shown that L. reuteri has valuable effects on host health. The current study firstly demonstrated that L. reuteri has a beneficial effect on the inflammation containing the variation of eicosanoids (PGE1 and PGE2) which are one of the most important biomarkers and moreover eicosanoid‐associated genes as well as proteins (COX‐2).

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Section: Discussionmentioning

confidence: 99%

“…L . reuteri LM1071 was obtained from LACTOMASON at a concentration of 4.8 × 10 9 cells g −1 (Kim et al, 2020). L .…”

Section: Methodsmentioning

confidence: 99%

Section: Lactic Acid Bacteria Strainmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%