Anti-inflammatory effects of intramammary infusions of glycyrrhizin in lactating cows with mastitis caused by coagulase-negative staphylococci

Kai, Kenzo; Komine, Ken Ichi; Asai, Ken Ichi; Kuroishi, Toshinobu; Komine, Yumiko; Kozutsumi, Tomoyuki; Itagaki, Masashi; Ohta, Michio; Endo, Yasuo; Kumagai, Katsuo

doi:10.2460/ajvr.2003.64.1213

Cited by 20 publications

(17 citation statements)

References 36 publications

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“…In addition, the anti-inflammatory activity of licorice has been already well documented (Imanishi et al, 1989;Ohtsuki et al, 1992;Nakamura et al, 1993). Our data are also supported by a study on lactating cows with mastitis caused by coagulase-negative staphylococci, in which a decrease of bacterial concentration and SCC in milk was demonstrated after intramammary infusions of glycyrrhizin (Kai et al, 2003).…”

Section: Discussionsupporting

confidence: 87%

Dietary supplementation of Saanen goats with dried licorice root modifies chemical and textural properties of dairy products

Bennato

Ianni

Martino

et al. 2020

Journal of Dairy Science

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The aim of the present study was to evaluate the effect of dietary integration with dried licorice root on the chemical-nutritional qualities of goat milk and cheeses. The study was conducted for 60 d, during which 30 Saanen goats were divided into 2 groups: a control group (CG) that received a standard diet and an experimental group (LG+) whose diet was supplemented with licorice. At the end of the study, milk samples were collected to determine chemicalnutritional compositions and fatty acid (FA) profiles. Cheeses produced with CG and LG+ bulk milk were analyzed for chemical-physical parameters after 3 (T3) and 30 (T30) d of ripening. A different FA profile and a significant increase in protein and casein were observed in LG+ milk samples compared with CG milk. Regarding cheeses, an increase of proteins and fat was found in LG+ cheeses, which also were harder, more elastic, and more gummy than the CG samples after both 3 and 30 d of ripening. A different protein profile was detected in the 2 groups without significant variations in casein fractions (α S2-casein and β-casein) during ripening. Moreover, greater oxidative stability was found in LG+ cheeses at both T3 and T30. Different families of volatile compounds were detected in T30 cheeses obtained from both groups. A significant reduction of octanoic acid and an increase in nonanal and ketones were found in LG+ T3 cheeses, whereas the LG+ T30 cheeses were characterized by a significant decrease of hexanoic acid an increase of 3-methyl-1-butanol and acetoin. We concluded that it is possible to assert that dietary integration with dried licorice root modified chemical and technological properties of goat cheeses, reducing lipid oxidation during ripening and inducing changes in texture that could improve consumer acceptability, although further studies are needed from this point of view.

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Section: Discussionsupporting

confidence: 87%

Dietary supplementation of Saanen goats with dried licorice root modifies chemical and textural properties of dairy products

Bennato

Ianni

Martino

et al. 2020

Journal of Dairy Science

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“…It was siginificantly higher in the rats of the CIA group than in the rats of all treatment and control groups. There were no significant differences among the rats in the TP 17 Original Paper TP 13.40 mg, GL 26.78 mg groups. However, the levels of TNF-a in the rats of the TP 13.40 mg and of the GL 26.78 mg groups were significantly higher than the ones in the TP 17.86 mg and in the TP 13.40 mg, GL 26.78 mg groups.…”

Section: Discussionmentioning

confidence: 81%

Therapeutic Effect of Combined Triptolide and Glycyrrhizin Treatment on Rats with Collagen Induced Arthritis

Zhang

Liu

et al. 2007

Planta Med

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For investigating the effects of a combination therapy of triptolide (TP) with glycyrrhizin (GL) in rats with collagen-induced arthritis (CIA), the arthritic index was examined, and the levels of anti-CII IgG, TNF-alpha and IL-10 in serum were measured by ELISA. Our results showed that combined triptolide and glycyrrhizin treatment (TP 13.40 microg, GL 26.78 mg) can reduce the arthritic index of CIA rats and decrease the level of anti-CII IgG and TNF-alpha in serum. The observed effect was similar to the one measured upon application of TP 17.86 microg, GL 26.78 mg and TP 17.86 microg. The level of IL-10 was not significantly different among the rats of the TP 17.86 microg, of the TP 17.86 microg, GL 26.78 mg and of the TP 13.40 microg, GL 26.78 mg groups while the IL-10 levels in rats of the TP 13.40 microg and GL 26.78 mg groups were significantly higher. Combined triptolide 13.40 microg and glycyrrhizin 26.78 mg can therefore significantly inhibit collagen induced arthritis, and the effect was similar to the one of triptolide at 17.86 microg.

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“…In Japan, it has been used clinically for more than 20 years for the treatment of patients with chronic hepatitis. To date, various immunomodulatory properties, including the inhibition of inflammatory responses [16,17], augmentation of NK cell activities [18], and induction of various cytokines from immunocompetent cells [19 -22], have been attributed to glycyrrhizin. The inhibitory effect of glycyrrhizin against Candida albicans and herpesvirus infections in immunocompromised hosts has been described [23,24].…”

Section: Introductionmentioning

confidence: 99%

Pivotal Advance: Glycyrrhizin restores the impaired production of β-defensins in tissues surrounding the burn area and improves the resistance of burn mice to Pseudomonas aeruginosa wound infection

Yoshida

Kobayashi³

et al. 2009

Journal of Leukocyte Biology

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The decreased production of antimicrobial peptides in tissues surrounding the burn sites has been described in patients with severe burn injury. Small numbers of Pseudomonas aeruginosa spread easily to the whole body of burn mice when infected at burn site tissues. Gr-1(+)CD11b(+) cells, demonstrated in tissues surrounding the burn site, are inhibitory on the production of antimicrobial peptides by EK. In this paper, the decreased production of antimicrobial peptides by EK influenced by Gr-1(+)CD11b(+) cells was shown to be restored by glycyrrhizin. CCL2 and IL-10 were determined to be effector soluble factors for the suppressor activities of Gr-1(+)CD11b(+) cells on antimicrobial peptide production by EK. However, Gr-1(+)CD11b(+) cells, which were treated previously with glycyrrhizin, did not produce these soluble factors. Also, sepsis stemming from P. aeruginosa burn-site infection was not demonstrated in burn mice treated with glycyrrhizin. These results suggest that through the improved production of antimicrobial peptides in tissues surrounding the burn area, sepsis stemming from P. aeruginosa wound infection is controllable by glycyrrhizin in severely burned mice.

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Anti-inflammatory effects of intramammary infusions of glycyrrhizin in lactating cows with mastitis caused by coagulase-negative staphylococci

Abstract: Infusion of GL may regulate intramammary inflammation through modulation of inflammatory mediators such as histamine.

Cited by 20 publications

References 36 publications

Dietary supplementation of Saanen goats with dried licorice root modifies chemical and textural properties of dairy products

Dietary supplementation of Saanen goats with dried licorice root modifies chemical and textural properties of dairy products

Therapeutic Effect of Combined Triptolide and Glycyrrhizin Treatment on Rats with Collagen Induced Arthritis

Pivotal Advance: Glycyrrhizin restores the impaired production of β-defensins in tissues surrounding the burn area and improves the resistance of burn mice to Pseudomonas aeruginosa wound infection

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