Anti-inflammatory effects of Huang-Lian-Jie-Du decoction, its two fractions and four typical compounds

Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells

“…C. chinensis is one of the herbal plants formulated for Huang-Lian-JieDu decoction (HLJDD) and Xiexin decoction (XXD), which have been used to treat inflammation for nearly two thousand years in the clinical practice of Traditional Chinese Medicine. HLJDD and XXD have been reported to attenuate inflammatory responses in carrageenan-induced mice paw edema and LPS-exposed rats (Lo et al, 2005a(Lo et al, , 2005bLu et al, 2011). In this study, coptisine was also found to suppress carrageenan-induced rats paw edema and production of NO and TNF-α in inflamed tissues, suggesting that coptisine is one of major constituents for the anti-inflammatory effects of HLJDD and XXD.…”

Novel quercetin-3-O-glucoside eicosapentaenoic acid ester ameliorates inflammation and hyperlipidemia

“…COX-2 is an inducible enzyme that catalyzes the conversion of AA to prostaglandins during an inflammation process (Jung et al 2007). The inhibition of COX-2 can facilitate the control and treatment of inflammatory diseases (Lu et al 2011). QE inhibited PGE 2 and COX-2 protein syntheses in the LPS-induced macrophages, compared with their acyl donor EPA and acceptor QG.…”

Protective effect ofPhellodendri Cortexagainst lipopolysaccharide-induced memory impairment in rats

“…In the Korean traditional medicine, PCE has been widely used to treat chronic inflammatory diseases and prevent bacterial infection of the respiratory system and gastrointestinal tract (Yang et al 2010;Lu et al 2011). Recently, several studies have shown that PCE had a protective role against ischemia-reperfusioninduced brain injury through the reduction of neutrophil infiltration into the brain (Hwang et al 2002b).…”

“…In Korean traditional medicine, Phellodendri Cortex extract (PCE) has been widely used to prevent bacterial infection of the respiratory system and to treat various chronic inflammatory diseases (Lu et al 2011). …”