Anti-inflammatory Effects of GTE in Eye Diseases

Li, Jian; Du, Lin; He, Jing; Chu, Kai On; Guo, Cosmos Liutao; Wong, Michael; Pang, Chi Pui; Chu, Wai Kit

doi:10.3389/fnut.2021.753955

Cited by 7 publications

(2 citation statements)

References 145 publications

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“…Tea has been shown to have beneficial effects against a variety of ocular diseases including glaucoma, age-related macular degeneration, uveitis and ocular surface inflammation through cellular, animal, and human experiments 14 . Kumar et al demonstrated an anti-cataract effect of epigallocatechin-3-gallate (EGCG), a major active constituent of green tea through inhibition of crystallin aggregation in vitro 15 .…”

Section: Discussionmentioning

confidence: 99%

Habitual Tea Consumption and Risk of Cataracts: A Longitudinal Study

et al. 2022

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We aimed to investigate the association between habitual tea consumption and the risk of developing cataracts in a large community-based cohort study. We prospectively collected volunteers from 29 recruitment centers that were ≧ 55 years old with no history of cataracts at the beginning of the study. There were 12,080 participants with available information in our study and were divided into two groups according to habitual tea consumption; non-tea-drinking and tea-drinking groups. The mean age was 59 years. Compared to the non-tea-drinking group, the tea-drinking group had a significantly lower incidence of developing cataracts (15.5% vs 12.1%) during follow-up of 46 months. In multivariate Cox proportional hazards regression analysis, the relative risk (RR) of incident cataracts was lower in the tea-drinking group than the non-tea-drinking group (RR = 0.848; 95% confidence interval [CI] = 0.751 to 0.957). Participants with ≧ 2 cups per day were associated with almost 16% reduction in the risk of developing cataracts compared with the non-tea-drinking group (RR = 0.844; 95% CI = 0.741 to 0.961). Our study suggests that habitual tea consumption can reduce the incidence of cataracts and raises the possibility that the tea content may slow the progression of cataracts.

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Section: Discussionmentioning

confidence: 99%

Habitual Tea Consumption and Risk of Cataracts: A Longitudinal Study

et al. 2022

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“…Epigallocatechin-3-gallate (EGCG), the most abundant polyphenolic constituent of green tea, possesses potent antioxidant, anti-inflammatory and antiapoptotic properties [25][26][27]. It has been reported that EGCG could suppress ER stress mediated-apoptosis to protect mice against cisplatin-induced nephrotoxicity [28].…”

Section: Introductionmentioning

confidence: 99%

Epigallocatechin-3-Gallate Protects Trabecular Meshwork Cells from Endoplasmic Reticulum Stress

Zhou

et al. 2022

Oxidative Medicine and Cellular Longevity

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Primary open-angle glaucoma (POAG) is the most common form of glaucoma, for which elevated intraocular pressure (IOP) is a major risk factor. IOP is mainly regulated by dynamic balance of aqueous humor (AH) production and outflow via the conventional trabecular meshwork/Schlemm’s canal (TM/SC) pathway. Dysfunctions of TM cells due to endoplasmic reticulum (ER) stress have been demonstrated to increase the resistance of AH outflow, resulting in IOP elevation. Epigallocatechin-3-gallate (EGCG), the most abundant polyphenolic component in green tea, has been shown to alleviate ER stress in several diseases while its potential roles in alleviating ER stress in TM cells have not been determined. In this study, we investigate the mitigation of tunicamycin-induced ER stress in TM cells by EGCG. MTT assay was used to measure the cell viability of human TM (HTM) cells and primary porcine TM (PTM) cells. ER stress levels in both HTM cells and primary PTM cells were detected by quantitative real-time PCR. The primary PTM cells isolated from porcine TM tissues were characterized by immunostaining. We found that 40 μM and 80 μM EGCG pretreatment substantially promoted HTM cell survival under 3 μM tunicamycin-induced ER stress. Pretreatment of 40 μM EGCG markedly reduced the expression of ER stress markers ATF4, HSPA5, and DDIT3, evoked by 3 μM tunicamycin in HTM cells. Furthermore, 40 μM EGCG pretreatment significantly decreased the expressions of ATF4, HSPA5, and DDIT3 at the mRNA level induced by 3 μM tunicamycin and improved cell viability in primary PTM cells. Our results show that EGCG is capable of protecting TM cells from ER stress. EGCG provides a promising therapeutic option for POAG treatment.

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