Anti-inflammatory effects of grape seed extract in hemodialysis patients; a pilot study

Abstract

Immune responses and inflammation are major risk factors for mortality in patients with end-stage renal disease (ESRD). Increased oxidative stress is a common feature of ESRD, and it has been speculated that it is interrelated to inflammation. In many studies it has been proved that red grape seed extract (RGSE) provides an antioxidant efficacy. Objectives: The aim of this study was to investigate the anti-inflammatory effects of RGSE in hemodialysis patients. Patients and Methods: Thirty hemodialysis individuals were divided into two groups that received either 200 mg/day of the RGSE or placebo for one month. Mean ± SD of age of patients was 58.5 ± 10.5 years. Duration of dialysis was 4 ± 3.4 years and 27 patients were male and 3 patients were female. After a 2-week washout period, the groups were crossed over for another one month. Markers of inflammation, lipid profiles and blood factors were measured at baseline after intervention with RGSE or placebo. Results: Our results showed that RGSE consumption could not make statistically significant changes in markers of inflammation, lipid profiles and blood factors in hemodialysis patients. Conclusion: Although RGSE could not improve markers of inflammation, lipid profiles and blood factors in hemodialysis subjects over a 1 month period. However, this result may be due to short period of treatment or low dose of RGSE. Further studies need to clear these contradictions.

The effects of grape seed extract on glycemic control, serum lipoproteins, inflammation, and body weight: A systematic review and meta‐analysis of randomized controlled trials

“…After screening 724 studies, 15 (Abedini et al, ; Alirezaei et al, ; Argani et al, ; Clifton, ; Kar, Laight, Rooprai, Shaw, & Cummings, ; Mellen, Daniel, Brosnihan, Hansen, & Herrington, ; Park, Edirisinghe, Choy, Waterhouse, & Burton‐Freeman, ; Pourghassem‐Gargari, Abedini, Babaei, Aliasgarzadeh, & Pourabdollahi, ; Sano et al, ; Sivaprakasapillai, Edirisinghe, Randolph, Steinberg, & Kappagoda, ; Taghizadeh, Malekian, Memarzadeh, Mohammadi, & Asemi, ; Terauchi et al, ; Turki et al, ; Vigna et al, ; Ward et al, ) of them were eligible to be included in this meta‐analysis. These studies were detected by a process that is shown in Figure .…”

“…General characteristics of eligible studies are summarized in Table . The studies were conducted in Italy (Vigna et al, ), Australia (Clifton, ; Ward et al, ), Japan (Sano et al, ; Terauchi et al, ), United Kingdom (Kar et al, ), United States (Mellen et al, ; Park et al, ; Sivaprakasapillai et al, ), Iran (Abedini et al, ; Alirezaei et al, ; Argani et al, ; Pourghassem‐Gargari et al, ; Taghizadeh et al, ), and Tunisia (Turki et al, ). Studies were published between 2003 and 2017.…”

“…Studies were published between 2003 and 2017. Ten studies (Abedini et al, ; Argani et al, ; Park et al, ; Pourghassem‐Gargari et al, ; Sano et al, ; Sivaprakasapillai et al, ; Taghizadeh et al, ; Terauchi et al, ; Turki et al, ; Ward et al, ) had parallel design and other (Alirezaei et al, ; Clifton, ; Kar et al, ; Mellen et al, ; Vigna et al, ) had crossover design. One study was performed on men (Vigna et al, ), two studies (Taghizadeh et al, ; Terauchi et al, ) on women, and other studies (Abedini et al, ; Alirezaei et al, ; Argani et al, ; Clifton, ; Kar et al, ; Mellen et al, ; Park et al, ; Pourghassem‐Gargari et al, ; Sano et al, ; Sivaprakasapillai et al, ; Turki et al, ; Ward et al, ) on both sexes.…”

“…Ten studies (Abedini et al, ; Argani et al, ; Park et al, ; Pourghassem‐Gargari et al, ; Sano et al, ; Sivaprakasapillai et al, ; Taghizadeh et al, ; Terauchi et al, ; Turki et al, ; Ward et al, ) had parallel design and other (Alirezaei et al, ; Clifton, ; Kar et al, ; Mellen et al, ; Vigna et al, ) had crossover design. One study was performed on men (Vigna et al, ), two studies (Taghizadeh et al, ; Terauchi et al, ) on women, and other studies (Abedini et al, ; Alirezaei et al, ; Argani et al, ; Clifton, ; Kar et al, ; Mellen et al, ; Park et al, ; Pourghassem‐Gargari et al, ; Sano et al, ; Sivaprakasapillai et al, ; Turki et al, ; Ward et al, ) on both sexes. Totally, 825 subjects (451 in intervention and 374 in control group) were enrolled in these studies (Abedini et al, ; Alirezaei et al, ; Argani et al, ; Clifton, ; Kar et al, ; Mellen et al, ; Park et al, ; Pourghassem‐Gargari et al, ; Sano et al, ; Sivaprakasapillai et al, ; Taghizadeh et al, ; Terauchi et al, ; Turki et al, ; Vigna et al, ; Ward et al, ).…”

“…One study was performed on men (Vigna et al, ), two studies (Taghizadeh et al, ; Terauchi et al, ) on women, and other studies (Abedini et al, ; Alirezaei et al, ; Argani et al, ; Clifton, ; Kar et al, ; Mellen et al, ; Park et al, ; Pourghassem‐Gargari et al, ; Sano et al, ; Sivaprakasapillai et al, ; Turki et al, ; Ward et al, ) on both sexes. Totally, 825 subjects (451 in intervention and 374 in control group) were enrolled in these studies (Abedini et al, ; Alirezaei et al, ; Argani et al, ; Clifton, ; Kar et al, ; Mellen et al, ; Park et al, ; Pourghassem‐Gargari et al, ; Sano et al, ; Sivaprakasapillai et al, ; Taghizadeh et al, ; Terauchi et al, ; Turki et al, ; Vigna et al, ; Ward et al, ). Mean age of the participants was between 19.8 (Taghizadeh et al, ) and 63.6 (Ward et al, ) years, and their mean BMI was between 21.3 ( Terauchi et al, ) and 37 (Sivaprakasapillai et al, ) kg/m 2 .…”