Anti-inflammatory effects of formoterol and ipratropium bromide against acute cadmium-induced pulmonary inflammation in rats

Zhang, Wenhui; Fiévez, Laurence; Cheu, Esteban; Bureau, Fabrice; Rong, Weifang; Zhang, Fan; Zhang, Yong; Advenier, C.; Gustin, Pascal

doi:10.1016/j.ejphar.2009.11.015

Cited by 53 publications

(70 citation statements)

References 51 publications

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“…Compared to the anti-inflammatory effects of a single administration of formoterol or ipratropium bromide against the acute cadmium-induced lung injuries reported in a previous study (Zhang et al, 2010), the anti-inflammatory properties of these drugs recorded in the present study appeared rather limited. To check whether this loss of effectiveness could be due to a desensitization process, the anti-inflammatory effects of both drugs against the acute pulmonary inflammation induced by a single dose of cadmium were investigated after a single or repeated bronchodilator administration.…”

Section: Measurement Of the Cadmium-induced Acute Pulmonary Inflammatcontrasting

confidence: 42%

“…The impact of bronchodilators on pulmonary MMP activity related to the pulmonary inflammation and emphysema is poorly documented. Recently, formoterol or ipratropium administrated alone has been found to inhibit the activity of gelatinase A (MMP-2) and gelatinase B (MMP-9) in rats exposed to a single dose of cadmium (Zhang et al, 2010). Whether this inhibitory effect can persist in a chronic inflammatory process remains unknown.…”

Section: Introductionmentioning

confidence: 99%

“…The same procedure was performed in animals pretreated with the same drugs but finally exposed to saline instead of cadmium (4 groups; n = 6 per group) for 60 min. Concentrations of drugs and duration of nebulization were determined from a previous study demonstrating the protective effects of these drugs against a single dose cadmium-induced acute pulmonary inflammation (Zhang et al, 2010). This exposure procedure was repeated 3 times per week during 5 weeks.…”

Section: Study Design and Experimental Protocolsmentioning

confidence: 99%

“…A sham group (n = 5) was designed in which animals were exposed to NaCl for 60 min after 5-week treatment with vehicle. They were sacrificed and the bronchoalveolar lavage was collected for cytological analysis as previously described (Zhang et al, 2010).…”

Section: Measurement Of the Cadmium-induced Acute Pulmonary Inflammatmentioning

confidence: 99%

“…These drugs primarily exhibit their bronchodilating properties but also exert anti-inflammatory effects observed in vitro (Gosens et al, 2006;Hanania and Moore, 2004) and in animal models of acute pulmonary inflammation induced by various agents including cadmium, one of the numerous components of tobacco smoke and a toxic ambient pollutant (McQueen et al, 2007;Miyamoto et al, 2004;Razani-Boroujerdi et al, 2008;Zhang et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Effects of formoterol and ipratropium bromide on repeated cadmium inhalation-induced pulmonary inflammation and emphysema in rats

Zhang

Fiévez

Zhang

et al. 2010

European Journal of Pharmacology

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The anti-inflammatory properties of inhaled formoterol and ipratropium bromide, alone or in combination, were investigated in a rat model of chronic pulmonary inflammation with airspace enlargement induced by cadmium inhalation. At the end of the protocol, cadmium-induced increase of airway resistance was prevented by formoterol (4 mg/30 ml) or ipratropium (0.20 mg/20 ml). Formoterol elicited a significant decrease in total cell and neutrophil counts in bronchoalveolar lavage fluid as well as on the activity of gelatinase B (MMP-9), an enzyme strongly expressed in alveolar macrophages and epithelial cells. Additionally, a significant attenuation of the lung lesions characterized by inflammatory cell infiltration within the alveoli and the interstitium and a decrease in mean linear intercept were observed. Although ipratropium alone had no effects on the cadmium-induced pulmonary inflammation and emphysema, its combination with an inefficient concentration of formoterol (1 mg/30 ml) showed a synergistic inhibitory effect on neutrophil and total cell counts as well as on the mean linear intercept associated with a synergistic inhibition on the MMP-9 activity. Gelatinase A (MMP-2) activity was not influenced by drug pretreatments. Neither macrophage metalloelastase (MMP-12) activity nor levels of cytokines IL-1β, TNF-α and GM-CSF in bronchoalveolar lavage fluid were modified in rats chronically exposed to cadmium. No desensitization of β 2 -adrenoceptors or cholinergic receptors on airway smooth muscles and inflammatory cells during the protocol was observed. In conclusion, formoterol alone or combined with ipratropium bromide partially protects the lungs against the chronic inflammation and airspace enlargement by reducing neutrophilic infiltration possibly via the inhibition of MMP-9 activity.

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Section: Measurement Of the Cadmium-induced Acute Pulmonary Inflammatcontrasting

confidence: 42%

Section: Introductionmentioning

confidence: 99%

Section: Study Design and Experimental Protocolsmentioning

confidence: 99%

Section: Measurement Of the Cadmium-induced Acute Pulmonary Inflammatmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of formoterol and ipratropium bromide on repeated cadmium inhalation-induced pulmonary inflammation and emphysema in rats

Zhang

Fiévez

Zhang

et al. 2010

European Journal of Pharmacology

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Adverse effects of cadmium on lymphoid organs, immune cells, and immunological responses

Kumari,

Nanda,

Firdaus

2024

J of Applied Toxicology

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Humans and animals possess robust immune systems to safeguard against foreign pathogens. However, recent reports suggest a greater incidence of immunity breakdown due to exposure to environmental pollutants, with heavy metals emerging as potential candidates in such immuno‐toxicological studies. While we have extensive data on the general toxicity resulting from exposure to heavy metals, comprehensive documentation of their role as immune disruptors remains scarce. Cd (Cadmium) exerts immunomodulation by interfering with immune organs and cells, leading to altered structure, physiology, and function, thereby inducing symptoms of immune deregulation, inflammation and/or autoimmunity.This review aims to summarize the link between Cd exposure and immune dysfunction, drawing from case studies on exposed human subjects, as well as research conducted on various model organisms and in‐vitro culture systems.

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The Relationship Between Oxidative Stress Responses and Lung Inflammation with Cigarette Smoking

Song

Kelsen

2013

Smoking and Lung Inflammation

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Anti-inflammatory effects of formoterol and ipratropium bromide against acute cadmium-induced pulmonary inflammation in rats

Cited by 53 publications

References 51 publications

Effects of formoterol and ipratropium bromide on repeated cadmium inhalation-induced pulmonary inflammation and emphysema in rats

Effects of formoterol and ipratropium bromide on repeated cadmium inhalation-induced pulmonary inflammation and emphysema in rats

Adverse effects of cadmium on lymphoid organs, immune cells, and immunological responses

The Relationship Between Oxidative Stress Responses and Lung Inflammation with Cigarette Smoking

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