Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure

Gielen, Stephan; Adams, Volker; Möbius‐Winkler, Sven; Linke, Axel; Erbs, Sandra; Yu, Jiangtao; Kempf, Werner; Schubert, Andreas; Schuler, Gerhard; Hambrecht, Rainer

doi:10.1016/s0735-1097(03)00848-9

Cited by 531 publications

(475 citation statements)

References 26 publications

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“…Chronic training has been shown to reduce the expression of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6 [8,9,26] According to Greiwe et al [10], expression of TNF-α expression in skeletal muscle is higher in elderly subjects compared to young subjects, but decreases after 3 months of resistance exercise. Our present results concerning ASC methylation are consistent with these studies.…”

Section: Discussionmentioning

confidence: 99%

Exercise Effects on Methylation ofASCGene

et al. 2010

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Chronic moderate exercise has been reported to reduce pro-inflammatory cytokines. To analyze the molecular mechanisms by which training exerts these effects, the epigenetic influences of age and exercise on the ASC gene, which is responsible for IL-1β and IL-18 secretion, were investigated by ASC gene methylation. Further, the relationship between carcinogenesis and exercise, methylation of the p15 tumor suppressive gene was analyzed as well. High-intensity interval walking exercise, consisting of 3-minute low-intensity walking at 40% of peak aerobic capacity followed by a 3-minute high-intensity walking period above 70% of peak aerobic capacity, was continued for 6 months. Peripheral blood DNA extracts from young control (n=34), older control (n=153), and older exercise (n=230) groups were then analyzed by pyrosequencing for DNA methylation. Methylation of ASC decreased significantly with age (young control vs. older control, p<.01), which is indicative of an age-dependent increase in ASC expression. Compared to the older control group, the degree of ASC methylation was higher in the older exercise group (older control vs. older exercise:, p<.01) and presumably lower ASC expression. Neither exercise nor age affected the methylation of the p15. In summary, chronic moderate exercise appears to attenuate the age-dependent decrease in ASC methylation, implying suppression of excess pro-inflammatory cytokines through reduction of ASC expression.

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Section: Discussionmentioning

confidence: 99%

Exercise Effects on Methylation ofASCGene

et al. 2010

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“…The pleiotropic stimulus of ET leaves room for mechanistic considerations regarding the beneficial effect of ET in HFpEF, including anti‐inflammation10 and reduced neuro‐hormonal activation 11. Hormonal alterations may play a pivotal role in mediating this process.…”

Section: Introductionmentioning

confidence: 99%

Ghrelin and hormonal markers under exercise training in patients with heart failure with preserved ejection fraction: results from the Ex‐DHF pilot study

et al. 2016

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BackgroundOver 50% of patients with symptomatic heart failure (HF) experience HF with preserved ejection fraction (HFpEF). Exercise training (ET) is effective in improving cardiorespiratory fitness and dimensions of quality of life in patients with HFpEF. A systemic pro‐inflammatory state induced by comorbidities as the cause of myocardial structural and functional alterations has been proposed in HFpEF. ET modifies myocardial structure and has been related to inflammatory state. We investigated Ghrelin, related adipokines, markers of inflammation, and neuro‐hormonal activation in patients undergoing a structured ET vs. usual care are with HFpEF. Methods and resultsEx‐DHF‐P was a prospective, controlled, randomized multi‐centre trial on structured and supervised ET in patients with HFpEF. We performed a post hoc analysis in 62 patients from Ex‐DHF‐P. Ghrelin, adiponectin, leptin, IL‐1ß, IL‐6, IL‐10, tumour necrosis factor‐alpha, MR‐proANP, MR‐proADM, CT‐proET1, and CT‐proAVP were assessed to seize the impact of ET on these markers in patients with HFpEF. Thirty‐six (58%) patients were female, mean age was 64 years, and median ghrelin was 928 pg/mL (interquartile range 755–1156). When stratified for high versus low ghrelin, groups significantly differed at baseline in presence obesity, waist circumference, and adiponectin levels (P < 0.05, respectively). Overall, ghrelin levels rose significantly to 1013 pg/mL (interquartile range 813–1182) (P < 0.001). Analysis of covariance modelling for change in ghrelin identified ET (P = 0.013) and higher baseline adiponectin levels (P = 0.035) as influencing factors.ConclusionsExercise training tended to increase ghrelin levels in Ex‐DHF‐P. This increase was especially pronounced in patients with higher baseline adiponectin levels. Future trials are needed to investigate the effect of ET on endogenous ghrelin levels in regard to interactions with cardiac structure and clinically meaningful surrogate parameters.

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“…85 Similarly, in a small RCT of patients with HF, both local expression of tumor-necrosis factor-α, interleukin-1β, and interleukin-6 decreased with regular ET in comparison with the sedentary groups. 86 In addition to affecting cardiac performance, ET improves lipid profiles. In a metaanalysis ET-based CR was associated with significant decreases in total cholesterol level (-14.3 mg/dL; 95% CI: -24.3 to -4.2 mg/dL) and triglycerides (-20.4 mg/dL; 95% CI:-34.5 to -6.2 mg/dL).…”

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confidence: 99%

Impact of cardiac rehabilitation and exercise training programs in coronary heart disease

Kachur

Chongthammakun

Lavie

et al. 2017

Progress in Cardiovascular Diseases

128

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Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure

Abstract: Exercise training significantly reduced the local expression of TNF-alpha, IL-1-beta, IL-6, and iNOS in the skeletal muscle of CHF patients. These local anti-inflammatory effects of exercise may attenuate the catabolic wasting process associated with the progression of CHF.

Cited by 531 publications

References 26 publications

Exercise Effects on Methylation ofASCGene

Exercise Effects on Methylation ofASCGene

Ghrelin and hormonal markers under exercise training in patients with heart failure with preserved ejection fraction: results from the Ex‐DHF pilot study

Impact of cardiac rehabilitation and exercise training programs in coronary heart disease

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