Anti‑inflammatory effects of Dendropanax�morbifera in lipopolysaccharide‑stimulated RAW264.7 macrophages and in an animal model of atopic dermatitis

Choo, Gang-Sik; Lim, Dong‐Pyo; Kim, Sae‐Man; Yoo, Eun‐Seon; Kim, Sung‐Hyun; Kim, Chang‐Hyun; Woo, Joong-Seok; Kim, Hyeong‐Jin; Jung, Ji‐Youn

doi:10.3892/mmr.2019.9887

Cited by 19 publications

(15 citation statements)

References 30 publications

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“…NO is a highly reactive compound produced from L‐arginine by NO synthase and is involved in pathogen defense, signal transduction, vasodilation, and various other physiological functions of the body. However, excessive NO formation intensifies inflammation, resulting in tissue damage, genetic variation, and nerve damage (Choo et al, 2019). As shown in Figure 5a, NO production significantly increased by 1 µg/ml LPS treatment in the negative control (94.84 ± 3.04 µM) and was suppressed by 38% upon treatment with 20 µM indomethacin, compared to the negative control.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and anti‐inflammatory effects of Lilium lancifolium bulbs extract

et al. 2020

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Lilium lancifolium is native to Northeast Asia and its bulbs have been used for medicinal treatment. Moreover, Japan has been using L. lancifolium bulbs more actively as food ingredients than Korea. Therefore, this study was to investigate the characteristics of Korean L. lancifolium bulbs, with respect to food component and functionality. As a result of proximate composition analysis, L. lancifolium bulbs have an abundant carbohydrate content. HPLC analysis indicated p‐coumaric acid and ferulic acid contents of Korean L. lancifolium extract were 1.14 ± 0.01, 1.46 ± 0.00 mg/g, but only p‐coumaric acid was less detected in Japanese extract. Also, Korean L. lancifolium bulbs extract exhibited significant antioxidant effects, as evaluated with antioxidant activity and compound, than Japanese extract. Furthermore, Korean L. lancifolium bulbs extract significantly inhibited pro‐inflammatory protein expressions through MyD88 dependent pathway. Therefore, these results suggested Korean L. lancifolium bulbs have the potential to being functional food ingredients. Practical applications Lilium lancifolium is a perennial plant belonging to the Liliaceae family. The storage organ of L. lancifolium is surrounded by several fleshy nodes at the base of the stem, called the bulb, which has been used as food or medicine to treat pneumonia and bronchitis. L. lancifolium is widely found in countries of Northeast Asia, such as Korea, Japan, and China, and its bulbs have been studied for presence of bioactive compounds that have important functional activities. The bioactive compounds in the L. lancifolium bulbs may vary from region to region. In this study, the difference observed in the contents of different bioactive compounds and the efficacy of anti‐inflammatory effects of L. lancifolium bulbs from different regions were consistent in this regard. As a comparative study of food materials by region, these L. lancifolium bulbs have the potential to be used as a food material for preventing inflammatory diseases.

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Section: Resultsmentioning

confidence: 99%

Antioxidant and anti‐inflammatory effects of Lilium lancifolium bulbs extract

et al. 2020

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“…Further, it was also determined that D. morbifera treatment significantly decreased NF-κB activation in the LPS-stimulated group. However, the activation of IκB-α was not significantly changed [ 17 ]. Other in vitro studies have suggested that D. morbifera extracts have anti-inflammatory activities.…”

Section: Medicinal Uses and Pharmacological Properties Of mentioning

confidence: 99%

“…Indeed, all species but D. morbiferus are native to the tropics of South Korea, predominantly found on Jeju Island [ 12 , 13 , 14 , 15 ]. Most species of the genus Dendropanax is historically important trees that are largely evergreen, and numerous parts of these plant species commonly been used by indigenous peoples to recover from various disorders, atopic dermatitis, asthma, sore throat, anemia, anti-oxidative, viral infections and kidney problems [ 16 , 17 , 18 , 19 ]. The traditional use of Dendropanax species was used for treating inflammatory and arthritis conditions [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Dendropanax Morbiferus and Other Species from the Genus Dendropanax: Therapeutic Potential of Its Traditional Uses, Phytochemistry, and Pharmacology

Balakrishnan¹,

Cho²,

Kim³

et al. 2020

Antioxidants

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The Dendropanax genus is a kind of flowering plant in the family of Araliaceae that encompasses approximately 91 to 95 species. Several Dendropanax species are used as traditional medicinal plants, extensively used Korea and South America and other parts of the world. Almost every part of the plant, including the leaves, bark, roots, and stems, can be used as traditional medicine for the prevention and management of a broad spectrum of health disorders. This paper sought to summarizes the ethnopharmacological benefits, biological activities, and phytochemical investigations of plants from the genus Dendropanax, and perhaps to subsequently elucidate potential new perspectives for future pharmacological research to consider. Modern scientific literature suggests that plants of the Dendropanax genus, together with active compounds isolated from it, possess a wide range of therapeutic and pharmacological applications, including antifungal, anti-complement, antioxidant, antibacterial, insect antifeedant, cytotoxic, anti-inflammatory, neuroprotective, anti-diabetic, anti-cancer, and anti-hypouricemic properties. The botanical descriptions of approximately six to 10 species are provided by different scientific web sources. However, only six species, namely, D. morbiferus, D. gonatopodus, D. dentiger, D. capillaris, D. chevalieri, and D. arboreus, were included in the present investigation to undergo phytochemical evaluation, due to the unavailability of data for the remaining species. Among these plant species, a high concentration of variable bioactive ingredients was identified. In particular, D. morbifera is a traditional medicinal plant used for the multiple treatment purposes and management of several human diseases or health conditions. Previous experimental evidence supports that the D. morbifera species could be used to treat various inflammatory disorders, diarrhea, diabetes, cancer, and some microbial infections. It has recently been reported, by our group and other researchers, that D. morbifera possesses a neuroprotective and memory-enhancing agent. A total of 259 compounds have been identified among six species, with 78 sourced from five of these species reported to be bioactive. However, there is no up-to-date information concerning the D. morbifera, its different biological properties, or its prospective benefits in the enhancement of human health. In the present study, we set out to conduct a comprehensive analysis of the botany, traditional medicinal history, and medicinal resources of species of the Dendropanax genus. In addition, we explore several phytochemical constituents identified in different species of the Dendropanax genus and their biological properties. Finally, we offer comprehensive analysis findings of the phytochemistry, medicinal uses, pharmacological actions, and a toxicity and safety evaluation of the D. morbifera species and its main bioactive ingredients for future consideration.

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“…However, studies on changes in the gut microbiome caused by medicinal plants and their effects on the prevention of liver damage are insufficient. Dendropanax morbifera , which belongs to the Araliaceae family, is a medicinal plant that grows on the southern coast of Korea and is known to have various physiological functions such as anti-inflammatory, anti-cancer, anti-diabetic, and immune regulatory effects [ 15 , 16 , 17 , 18 ]. In addition, a previous study conducted by our research team showed that D. morbifera extract, with its maximal antioxidant activity, inhibited liver damage caused by oxidative stress [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Dendropanax morbifera Leaf Extracts Improved Alcohol Liver Injury in Association with Changes in the Gut Microbiota of Rats

Eom

Kim

et al. 2020

Antioxidants

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This study evaluated the protective effects of Dendropanax morbifera leaf (DML) extracts in the liver due to excessive ethanol consumption. Our results showed that the ethanol extract had better antioxidant activity than the water extract, likely due to the higher levels of total flavonoid and phenolic compounds in the former. We found that the main phenolic acid was chlorogenic acid and the major flavonoid was rutin. Results from the animal model experiment showed concentration-dependent liver protection with the distilled water extract showing better liver protection than the ethanol extract. Gut microbiota dysbiosis induced by alcohol consumption was significantly shifted by DML extracts through increasing mainly Bacteroides and Allobaculum. Moreover, predicted metabolic activities of biosynthesis of beneficial monounsaturated fatty acids such as oleate and palmitoleate were enhanced. Our results suggest that these hepatoprotective effects are likely due to the increased activities of antioxidant enzymes and partially promoted by intestinal microbiota shifts.

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Anti‑inflammatory effects of Dendropanax�morbifera in lipopolysaccharide‑stimulated RAW264.7 macrophages and in an animal model of atopic dermatitis

Cited by 19 publications

References 30 publications

Antioxidant and anti‐inflammatory effects of Lilium lancifolium bulbs extract

Antioxidant and anti‐inflammatory effects of Lilium lancifolium bulbs extract

Dendropanax Morbiferus and Other Species from the Genus Dendropanax: Therapeutic Potential of Its Traditional Uses, Phytochemistry, and Pharmacology

Dendropanax morbifera Leaf Extracts Improved Alcohol Liver Injury in Association with Changes in the Gut Microbiota of Rats

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