Anti-inflammatory effects of Cryptotympana atrataFabricius slough shed on contact dermatitis induced by dinitrofluorobenzene in mice

Kim, Miyoung; Kim, Hanna; Ryu, Jeonghyun; Jo, Suzy; Lee, Guemsan; Ryu, Mi Heon; Kim, Hyungwoo; Cho, Su-In

doi:10.4103/0973-1296.133288

Cited by 9 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, topical as well systemic administration of dexamethasone reduces the spleen and body weight of laboratory animals, and such a decrease in spleen and body weight is generally recognized as one of the side effects caused by the suppression of immune function [38]. In this study, it was confirmed that parnassin exhibited similar efficacy to dexamethasone for AD in experimental animals.…”

Section: Discussionsupporting

confidence: 71%

Parnassin, a Novel Therapeutic Peptide, Alleviates Skin Lesions in a DNCB-Induced Atopic Dermatitis Mouse Model

et al. 2023

View full text Add to dashboard Cite

Atopic dermatitis (AD) is a chronic inflammatory skin disease which requires continuous treatment due to its relapsing nature. The current treatment includes steroids and nonsteroidal agents targeting inflammation but long-term administration causes various side effects such as skin atrophy, hirsutism, hypertension and diarrhea. Thus, there is an unmet need for safer and effective therapeutic agents in the treatment of AD. Peptides are small biomolecule drugs which are highly potent and remarkably have less side effects. Parnassin is a tetrapeptide with predicted anti-microbial activity curated from Parnassius bremeri transcriptome data. In this study, we confirmed the effect of parnassin on AD using a DNCB-induced AD mouse model and TNF-α/IFN-γ-stimulated HaCaT cells. In the AD mouse model, topical administration of parnassin improved skin lesions and symptoms in AD mice, such as epidermal thickening and mast cell infiltration, similar to the existing treatment, dexamethasone, and did not affect body weight, or the size and weight of spleen. In TNF-α/IFN-γ-stimulated HaCaT cells, parnassin inhibited the expression of Th2-type chemokine CCL17 and CCL22 genes by suppressing JAK2 and p38 MAPK signaling kinases and their downstream transcription factor STAT1. Parnassin also significantly reduced the gene expression of TSLP and IL-31, which are pruritus-inducing cytokines. These findings suggested that parnassin alleviates AD-like lesions via its immunomodulatory effects and can be used as a candidate drug for the prevention and treatment of AD because it is safer than existing treatments.

show abstract

Section: Discussionsupporting

confidence: 71%

Parnassin, a Novel Therapeutic Peptide, Alleviates Skin Lesions in a DNCB-Induced Atopic Dermatitis Mouse Model

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Recent studies have shown that the CP has inhibitory effects on Th17 differentiation [ 6 ], allergic rhinitis [ 7 ], anaphylactic reactions [ 8 ], and contact dermatitis [ 36 ]. The CP improved kidney inflammation and fibrosis in IgA nephropathy rat models by reducing MCP-1, TNF-α, IL-1β, and IL-6 levels [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Cryptotympana pustulata Extract and Its Main Active Component, Oleic Acid, Inhibit Ovalbumin-Induced Allergic Airway Inflammation through Inhibition of Th2/GATA-3 and Interleukin-17/RORγt Signaling Pathways in Asthmatic Mice

et al. 2021

View full text Add to dashboard Cite

Cicadae Periostracum (CP), derived from the slough of Cryptotympana pustulata, has been used as traditional medicine in Korea and China because of its diaphoretic, antipyretic, anti-inflammatory, antioxidant, and antianaphylactic activities. The major bioactive compounds include oleic acid (OA), palmitic acid, and linoleic acid. However, the precise therapeutic mechanisms underlying its action in asthma remain unclear. The objective of this study was to determine the antiasthmatic effects of CP in an ovalbumin (OVA)-induced asthmatic mouse model. CP and OA inhibited the inflammatory cell infiltration, airway hyperresponsiveness (AHR), and production of interleukin (IL)7 and Th2 cytokines (IL-5) in the bronchoalveolar lavage fluid and OVA-specific imunoglobin E (IgE) in the serum. The gene expression of IL-5, IL-13, CCR3, MUC5AC, and COX-2 was attenuated in lung tissues. CP and OA might inhibit the nuclear translocation of GATA-binding protein 3 (GATA-3) and retinoic acid receptor-related orphan receptor γt (RORγt) via the upregulation of forkhead box p3 (Foxp3), thereby preventing the activation of GATA-3 and RORγt. In the in vitro experiment, a similar result was observed for Th2 and GATA-3. These results suggest that CP has the potential for the treatment of asthma via the inhibition of the GATA-3/Th2 and IL-17/RORγt signaling pathways.

show abstract

“…A study found that the methanol extract of the cicada slough can effectively inhibit ear swelling and hyperplasia, through experiments on contact dermatitis in mice [26]. The curative effect of the cicada slough is mediated by reducing the production of TNF-α, IFN-g and IL-6 in inflammation, which indicates that the cicada slough has the medicinal value of anti-inflammatory effect [26]. The extract of the cicada slough also has the obvious bacteriostatic effect [27].…”

Section: Antibacterial and Anti-inflammatory Effectsmentioning

confidence: 99%

Edible and Medicinal Progress of Cryptotympana atrata (Fabricius) in China

Xie,

Guo,

Liu

et al. 2023

Nutrients

View full text Add to dashboard Cite

As an important resource insect, the Cryptotympana atrata is widely distributed in the eastern and central parts of China. The cicada slough is one of the traditional crude drugs in East Asia, and the main component is polysaccharide, which has the functions of anti-convulsion, relieving asthma and improving lipid metabolism. The parasitoid fungus Cordyceps cicadae, which grows inside the cicada nymphs and forms the fruiting bodies on the surface of the host’s carcass, is also known as the “cicada flower” in China. The Cordyceps cicadae is another old, traditional Chinese medicine, which has been used as a tonic and medicine to nourish and regulate human immunity for centuries. For the further development and utilization of the golden cicada, this paper summarized the C. atrata from the aspects of their biological characteristics, distribution area, life cycle, history of edible and medicinal use, edible methods and nutritional compositions; emphatically introduced the edible and potential medicinal value of the C. atrata; and specifically expounded the research progress of its application. As one popular insect food, the prospects for the development of C. atrata have also been put forward, especially in artificial breeding technology, food safety risk assessment and medicinal value utilization.

show abstract

Anti-inflammatory effects of Cryptotympana atrataFabricius slough shed on contact dermatitis induced by dinitrofluorobenzene in mice

Cited by 9 publications

References 15 publications

Parnassin, a Novel Therapeutic Peptide, Alleviates Skin Lesions in a DNCB-Induced Atopic Dermatitis Mouse Model

Parnassin, a Novel Therapeutic Peptide, Alleviates Skin Lesions in a DNCB-Induced Atopic Dermatitis Mouse Model

Cryptotympana pustulata Extract and Its Main Active Component, Oleic Acid, Inhibit Ovalbumin-Induced Allergic Airway Inflammation through Inhibition of Th2/GATA-3 and Interleukin-17/RORγt Signaling Pathways in Asthmatic Mice

Edible and Medicinal Progress of Cryptotympana atrata (Fabricius) in China

Contact Info

Product

Resources

About