Anti-inflammatory Effects of Compounds from Polygonum odoratum

Abstract

Polygonum odoratum is an edible plant traditionally used as an antidiabetic, antimicrobial, anti-inflammatory, and antitumor agent in Asia. The aim of the study was to evaluate the anti-inflammatory effect of P. odoratum and the isolation and characterization of its main fractions. Extracts of the aerial parts were tested for anti-inflammatory activity as indicated by a change in the cytokine secretion in lipopolysaccharide-stimulated macrophages. After separation of the extract by reversed-phase high-performance liquid chromatography, the anti-inflammatory activity of the fractions was determined. Furthermore, the two main fractions were identified by nuclear magnetic resonance spectroscopy (1 Hand 13 C-NMR). The ethanolic extract significantly reduced IL-6 secretion (IC 50 25 µg/mL). The two main fractions (5 and 7) significantly decreased IL-6 production with an IC 50 of 102 µM (5) and 77 µM (7), respectively, and were identified as scutellarein-7-glucoside (5) and quercitrin (7). Since inflammation plays a major role in various diseases with high prevalence globally, it may be of importance that P. odoratum and its main constituents scutellarein-7-glucoside and quercitrin can be used as either an alternative or complementary treatment. Additionally, both are glycosides and their activity may be enhanced tremendously by deglycosylation by the gut microbiota.

Natural derivatives with dual binding potential against SARS-CoV-2 main protease and human ACE2 possess low oral bioavailability: a brief computational analysis

“…Biologically scutellarein 7-glucoside shows anti-inflammatory activity by decreasing the IL-6 and TNF-α production as reported by Okonogi et al. ( 2016 ). Another study reported by Goran et al., shows its certain inhibitory activity against indole-3-acetic acid oxidase there by inhibiting ATP formation inside the plant mitochondria (Stenlid, 1976 ).…”

“…In the free form zinc makes coordination bonds with three residues (HIS 374 , HIS 378 and GLU 402 ) and a water molecule (Towler et al, 2004). The leads are explored under two key categories (a) drug candidates undergoing clinical evaluation and (b) natural products (Arts et al, 2004;McGhie & Walton, 2007;Okonogi et al, 2016;Paul et al, 2018;Stenlid, 1976;Yuldashev, 2002) (Table 1). Glide (Friesner et al, 2004) Extra Precision (XP) approach was used for screening of candidates followed by calculation of MM-GBSA energies to increase accuracy, and reliability of the docking process.…”

“…The second lead compound is a flavonoid glycoside, Scutellarein 7-glucoside isolated from plants like Verbena officinalis L (Rehecho et al, 2011), Buddleja madagascariensis Lam (Emam et al, 1998), Plantago asiatica L, Scutellaria immaculate (Yuldashev, 2002), Plantago asiatica L and Polygonum odoratum (Okonogi et al, 2016). Biologically scutellarein 7-glucoside shows anti-inflammatory activity by decreasing the IL-6 and TNF-a production as reported by Okonogi et al (2016). Another study reported by Goran et al, shows its certain inhibitory activity against indole-3acetic acid oxidase there by inhibiting ATP formation inside the plant mitochondria (Stenlid, 1976).…”

The Phytochemical and Pharmacological Properties of Persicaria odorata: A Review

“…The anti-inflammatory activity of P. odorata aerial extracts was discovered by Onkologi et al [44] in 2016. This analysis used three different solvents for extraction: water, 50% ethanol in water and ethanol.…”

“…P. odorata is also being taken by the Chinese Buddhist to reduce sexual desire [13]. Other than that, P. odorata has many pharmacological effects such as anticancer, antibacterial, anti-inflammatory, anti-fungal and antioxidant [14][15][16][17].…”