Anti-inflammatory effects of aspirin and sodium salicylate

Amann, Rainer; Peskar, Bernhard A.

doi:10.1016/s0014-2999(02)01828-9

Cited by 311 publications

(227 citation statements)

References 97 publications

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“…Considering these data, and also similar findings in literature [34], it appears that ASA most often has an inhibitory effect towards intracellular kinases and transcription factors alike, explaining its anti-inflammatory efficacy. However, we observed that 1 mM ASA upregulated the expression of the pro-inflammatory COX-2 protein in mast cells.…”

Section: Discussionsupporting

confidence: 88%

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Dual effects of acetylsalicylic acid on mast cell degranulation, expression of cyclooxygenase-2 and release of pro-inflammatory cytokines

Mortaz

Redegeld

Nijkamp

et al. 2005

Biochemical Pharmacology

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Several studies have demonstrated that nonsteroidal anti-inflammatory drugs, such as acetylsalicylic acid (ASA), can have inhibitory or enhancing effects on inflammatory cell function. These effects seem independent of cyclooxygenase activity and prostaglandin synthesis inhibition. Here, we examined the effect of ASA on bone marrow-derived mast cells in more detail. ASA blocked the expression of cyclooxygenase-2, the production of tumor necrosis factor-a and interleukin-6, and the release of granule mediators from mast cells in a concentration-dependent fashion. Concomitantly, ASA inhibited nuclear factor (NF)-kB activity, as well as the phosphorylation and breakdown of the inhibitory protein IkB-a. We thus propose that the anti-inflammatory effects of ASA in mast cells are due to suppression of IkB kinase activity, thereby inhibiting subsequent phosphorylation and degradation of IkB-a, activation of NF-kB, and transcription of proinflammatory cytokines. The inhibition of BMMC degranulation was independent of NF-kB activation, however. Interestingly, the expression of cyclooxygenase-2 was not inhibited at 1 mM ASA, but was even enhanced significantly. The latter might contribute to the adverse effects of ASA in ASA-sensitive asthmatics. #

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Section: Discussionsupporting

confidence: 88%

“…Serum concentrations have been reported to be as high as 2 mM in patients treated for chronic inflammatory diseases [34]. Moreover, the acidic nature of ASA results in accumulation in acidic body compartments, such as inflamed tissues, because of the increased lipophilicity of ASA under these conditions [35,36].…”

Section: Discussionmentioning

confidence: 99%

Dual effects of acetylsalicylic acid on mast cell degranulation, expression of cyclooxygenase-2 and release of pro-inflammatory cytokines

Mortaz

Redegeld

Nijkamp

et al. 2005

Biochemical Pharmacology

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“…Sodium salicylate is a biotransformation product of aspirin that possesses similar anti-inflammatory potency as aspirin, through its inhibition of prostaglandin synthesis on inflammatory cells (8)(9)(10). In addition, a recent study demonstrated that salicylate could suppress integrindependent neutrophil aggregation (11).…”

Section: Introductionmentioning

confidence: 99%

Linking Inflammation to Acute Rejection in Small-For-Size Liver Allografts: The Potential Role of Early Macrophage Activation

Yang

Chu

et al. 2004

American Journal of Transplantation

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This study aims to investigate the immunological status of small-for-size liver allografts and possible mechanism that contributes to the accelerated immune response in these allografts. Eight experimental groups were: whole isografts; 40% isografts; whole allografts, no treatment; 40% allografts, no treatment; whole allografts with sodium salicylate intraperitoneal injection, D0-3; 40% allografts with sodium salicylate, D0-3; whole allografts with FK506 intramuscular injection D0-3, and 40% allografts with FK506, D0-3. The 40% allografts survived significantly shorter than whole allografts (p = = 0.02). At 72 h after reperfusion, a higher number of macrophages infiltrated into the periportal area of small-for-size allografts than whole allografts. Remarkable up-regulation of interleukin-1b (IL-1b ), interleukin-2 (IL-2), interleukin-10 (IL-10) and interferon-c (IFN-c ) messenger RNA (mRNA) levels were detected in small-for-size allografts within 24 h after reperfusion. Sodium salicylate administration reduced IL-1b and IFN-c mRNA in both small-for-size and whole allografts, but it could decrease IL-2 and IL-10 mRNA levels only in small-for-size allografts. In vitro study revealed that CD80, CD86 and CD11b expression on macrophages was augmented after IL-1b stimulation, whereas the up-regulation could be blocked by sodium salicylate. In conclusion, early activation of macrophages as a result of graft injury might play an important role in the accelerated acute rejection process in small-for-size allografts.

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“…Its antipyretic, analgesic and antiinflammatory actions are based on irreversible inhibition of the cyclooxygenase enzyme that is responsible for the prostaglandin synthesis and some autacoids (Catella-Lawson, 2001;Amann and Peskar, 2002;Aude and Mehta, 2002). The acetylsalicylic acid effects on thrombotic phenomenon seem to be mainly a result of its antiplatelet action (Grotta et al, 1985;CatellaLawson, 2001).…”

Section: Introductionmentioning

confidence: 99%

Acetylsalicylic acid and labeling of blood constituents with technetium-99m

Fonseca¹,

Frydman

Rocha

et al. 2005

Braz. arch. biol. technol.

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Acetylsalicylic acid is the drug most used an anti-inflammatory agent and for secondary prevention of thrombotic phenomenon. Drugs can modify the labeling of blood constituents with technetium-99m (99mTc). The aim of this work was to evaluate the effect of in vitro or in vivo assays with acetylsalicylic acid on the labeling of the blood constituents with 99mTc. In vitro assay was performed with samples of whole blood from

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Anti-inflammatory effects of aspirin and sodium salicylate

Cited by 311 publications

References 97 publications

Dual effects of acetylsalicylic acid on mast cell degranulation, expression of cyclooxygenase-2 and release of pro-inflammatory cytokines

Dual effects of acetylsalicylic acid on mast cell degranulation, expression of cyclooxygenase-2 and release of pro-inflammatory cytokines

Linking Inflammation to Acute Rejection in Small-For-Size Liver Allografts: The Potential Role of Early Macrophage Activation

Acetylsalicylic acid and labeling of blood constituents with technetium-99m

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