Anti-inflammatory effects of Asparagus cochinchinensis extract in acute and chronic cutaneous inflammation

Lee, Doyeon; Choo, Byung-Kil; Yoon, Taesook; Cheon, Myeong Sook; Lee, Hye Won; Lee, A Yeong; Kim, Ho Kyoung

doi:10.1016/j.jep.2008.07.006

Cited by 97 publications

(40 citation statements)

References 20 publications

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“…However, they can frequently exhibit a set of undesirable side effects and are not effective in all cases (Schoepe et al, 2006). As alternative, extracts and isolated compounds from herbal medicine have been studied in order to discover new effective and safe topical anti-inflammatory drugs (Cordell and Colvard, 2005;Khanna et al, 2007;Lee et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Topical anti-inflammatory effect of Caryocar coriaceum Wittm. (Caryocaraceae) fruit pulp fixed oil on mice ear edema induced by different irritant agents

Saraiva

Araruna

Oliveira

et al. 2011

Journal of Ethnopharmacology

108

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Section: Introductionmentioning

confidence: 99%

Topical anti-inflammatory effect of Caryocar coriaceum Wittm. (Caryocaraceae) fruit pulp fixed oil on mice ear edema induced by different irritant agents

Saraiva

Araruna

Oliveira

et al. 2011

Journal of Ethnopharmacology

108

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“…Extracts of A. cochinchinensis roots have been used in Korea to treat neuro-inflammatory and skin-inflammatory diseases for many years (1,25,27). Several studies have, therefore, focused on A. cochinchinensis to develop therapies against lung-inflammatory disease (28,34).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, extracts from A. cochinchinensis have previously been demonstrated to effectively regulate the expression of various cytokines; the increase of TNF-α secretion in astrocytes induced by substance P + LPS and ethanol treatment was significantly inhibited by ethanol extracts (70%) of A. cochinchinensis (ACE) in a dose dependent manner (21,25). Production of pro-inflammatory cytokines, including IL-1β and TNF-α has also been previously demonstrated to be suppressed by ACE in mice with phorbol ester-induced dermatitis (27). In the present study, the transcript and protein levels of pro- and anti-inflammatory cytokines in RAW264.7 cells were measured following EaEAC + LPS treatment, revealing similar suppressive activities compared with previous studies, despite certain differences in the reduction rate and the composition of the extracts.…”

Section: Discussionmentioning

confidence: 99%

“…Aspacochinosides N, O and P extracted from ethanol-treated A. cochinchinesis decreased the nitric oxide (NO) concentration in LPS-stimulated BV-2 microglial cells (26). Furthermore, ethanol extract from A. cochinchinesis decreased the degree of ectopic edema, ear thickness, cytokine secretion TNF-α and interleukin (IL)-1β and myeloperoxidase activity in a skin inflammation-induced mouse model treated with 12-O-tetradecanoyl-phorbol-13-acetate, all of which are considered indicators of skin inflammation progression (27). A crude aqueous extract of A. cochinchinensis effectively inhibited TNF-α-induced cytotoxicity (21), increased the spleen index and superoxide dismutase (SOD) activity and decreased malondialdehyde (MDA) in mice (1).…”

Section: Introductionmentioning

confidence: 99%

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Ethyl acetate extract from Asparagus cochinchinensis exerts anti-inflammatory effects in LPS-stimulated RAW264.7 macrophage cells by regulating COX-2/iNOS, inflammatory cytokine expression, MAP kinase pathways, the cell cycle and anti-oxidant activity

Lee

Koh

Sung

et al. 2017

Molecular Medicine Reports

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Asparagus cochinchinesis (A. cochinchinesis) is a medicine traditionally used to treat fever, cough, kidney disease, breast cancer, inflammatory disease and brain disease in northeast Asian countries. Although numerous studies of the anti-inflammatory effects of A. cochinchinesis have been conducted, the underlying mechanisms of such effects in macrophages remain to be demonstrated. To investigate the mechanism of suppressive effects on the inflammatory response in macrophages, alterations of the nitric oxide (NO) level, the cell viability, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression levels, inflammatory cytokine expression, the mitogen-activated protein kinase (MAPK) signaling pathway, cell cycle arrest and reactive oxygen species (ROS) levels were measured in lipopolysaccharide (LPS)-activated RAW264.7 cells following treatment with ethyl acetate extract from A. cochinchinesis root (EaEAC). RAW264.7 cells pretreated two different concentrations of EaEAC prior to LPS treatment exhibited no significant toxicity. The concentration of NO was significantly decreased in the EaEAC + LPS treated group compared with the vehicle + LPS treated group. A similar decrease in mRNA transcript level of COX-2, iNOS, pro-inflammatory cytokines [tumor necrosis factor-α and interleukin (IL)-1β] and anti-inflammatory cytokines (IL-6 and IL-10) was detected in the EaEAC + LPS treated group compared with the vehicle + LPS treated group, although the decrease rate varied. Enhancement of the phosphorylation of MAPK family members following LPS treatment was partially rescued in the EaEAC pretreated group, and the cell cycle was arrested at the G2/M phase. Furthermore, the EaEAC pretreated group exhibited a reduced level of ROS generation compared with the vehicle + LPS treated group. Taken together, these results suggest that EaEAC suppresses inflammatory responses through inhibition of NO production, COX-2 expression and ROS production, as well as differential regulation of inflammatory cytokines and cell cycle in RAW264.7 cells. In addition, these results provide strong evidence to suggest that EaEAC may be considered as an important candidate for the treatment of particular inflammatory diseases.

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“…Merr. is distributed in northeastern Asia (Xiong et al, 2011) and has been used in traditional medicine in Korea and China (Lee et al, 2009). The tuberous roots of this plant have various medicinal properties including anti-inflammatory (Lee et al, 2015), antibacterial, and antipyretic qualities (Samad et al, 2013).…”

mentioning

confidence: 99%

Development of microsatellite markers based on expressed sequence tags in Asparagus cochinchinensis (Asparagaceae)

et al. 2017

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Premise of the study:Transcriptome-derived simple sequence repeat (SSR) markers were developed in Asparagus cochinchinensis (Asparagaceae). Due to its application in traditional medicine, its wild populations are threatened by over-collection even in protected areas, requiring immediate conservation efforts.Methods and Results:Based on transcriptome data of A. cochinchinensis, 96 primer pairs with two to seven alleles per locus were selected for initial validation; of those, 27 primer pairs amplified across all samples, resulting in 15 polymorphic and 12 monomorphic microsatellite markers. The usefulness of these markers was assessed in 60 individuals representing three populations of A. cochinchinensis. Observed and expected heterozygosity values ranged from 0.050 to 0.950 and 0.049 to 0.626, respectively. Cross-species amplification of the 27 markers was tested in the related species A. rigidulus and A. schoberioides.Conclusions:These polymorphic, transcriptome-derived SSR markers can be used as molecular markers to study population genetics and ecological conservation in A. cochinchinensis and related taxa.

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Anti-inflammatory effects of Asparagus cochinchinensis extract in acute and chronic cutaneous inflammation

Cited by 97 publications

References 20 publications

Topical anti-inflammatory effect of Caryocar coriaceum Wittm. (Caryocaraceae) fruit pulp fixed oil on mice ear edema induced by different irritant agents

Topical anti-inflammatory effect of Caryocar coriaceum Wittm. (Caryocaraceae) fruit pulp fixed oil on mice ear edema induced by different irritant agents

Ethyl acetate extract from Asparagus cochinchinensis exerts anti-inflammatory effects in LPS-stimulated RAW264.7 macrophage cells by regulating COX-2/iNOS, inflammatory cytokine expression, MAP kinase pathways, the cell cycle and anti-oxidant activity

Development of microsatellite markers based on expressed sequence tags in Asparagus cochinchinensis (Asparagaceae)

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