Anti-inflammatory effects of Asparagus cochinchinensis extract in acute and chronic cutaneous inflammation

Lee, D. Y.; Choo, Byung-Kil; Yoon, Taesook; Cheon, Myeong-Sook; Choi, Goya; Lee, A. Y.; Moon, Byeong-Cheol; Kim, H. K.

doi:10.1055/s-0028-1084043

Cited by 9 publications

(11 citation statements)

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“…E.alba methanolic extract (200 and 400mg/kg) supplementation signi icantly (p<0.05) increased the antioxidant level as that of the arthritic rats. The data are shown in Table 3. RA is an in lammatory joint disease and the etiological factors linked with this disease is still obscure (Lee et al, 2009;Karmakar et al, 2010). Further, it also affects the immune system and other vital organs.…”

Section: Effect Of Ealba On Antioxidant Status In Arthritic Ratsmentioning

confidence: 99%

Anti-arthritic evaluation of Eclipta alba in a murine model Freund’s adjuvant provoked arthritis

Satishchandra

2020

ijrps

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Eclipta alba (E.alba) is a medicinal plant with wide range of biological action encompassing antioxidant and anti-inflammatory. However, its anti arthritic activity is not reported till date. So we have evaluated the anti-arthritic property of E.alba methanolic extract in arthritis induced rats. The rats were made arthritic by single intradermal injection of complete freunds adjuvant (CFA) and E.alba (200 and 400mg/kg) were administered for 28 days. The assessment of arthritis was done by evaluating body weight, paw volume and alteration in hematological parameters (WBC, RBC, Hb and ESR). Further, to evaluate oxidative stress, malondialdehyde (MDA), a marker of lipid peroxidation and antioxidants (SOD, CAT, GPx and GSH) were measured. The arthritis induced rats showed significant decrease in body weight, elevated paw oedema, and changes in blood parameters. Treatment with E.alba significantly reduced the arthritic symptoms by its anti-inflammatory effect. Further, arthritic rats displayed elevated MDA and decreased antioxidant levels and treatment with E.alba inhibited the lipid peroxidation and restored the antioxidants to normal. The present study reveals that Eclipta alba showed effective anti-arthritic activity through its antioxidant and anti-inflammatory property. Further the anti-arthritic activity of E. alba might be due to the presence of various phytochemicals such as flavanoids and polyphenols.

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Section: Effect Of Ealba On Antioxidant Status In Arthritic Ratsmentioning

confidence: 99%

Anti-arthritic evaluation of Eclipta alba in a murine model Freund’s adjuvant provoked arthritis

Satishchandra

2020

ijrps

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“…These include β-sitosterol [19], daucosterol [25], n-ethatriacontanoic acid [31], palmitic acid [14], 9-heptacosylene [41], smilagenin [3], diosgenin [6], sarsasapogenin-3-O-β-D-glucoside feeding grapes imidacloprid [39], 5-methoxy methyl furfural, yame sapogenin, diosgenin-3-O-β-D imidacloprid feeding glucose glycosides [29,39], aspacochioside D [30], iso-agatharesinoside [18] and seven steroidal saponins [15]. Among these, some polysaccharides exhibited therapeutic effects against several diseases such as aging [15,27,43], inflammatory diseases [15], tumor [11,20,36], diabetes [42] and cough [20,22].…”

Section: Introductionmentioning

confidence: 99%

Effects of an Aqueous Extract of Asparagus cochinchinensis on the Regulation of Nerve Growth Factor in Neuronal Cells

Lee¹,

Kim²,

Song³

et al. 2016

Journal of Life Science

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Asparagus cochinchinensis is a medical plant that has long been used to treat fever, cough, kidney disease, breast cancer, inflammatory disease and brain disease in northeast Asian countries. Although several studies have been conducted on the anti-neuroinflammatory effects of A. cochinchinensis, the correlation between these effects and nerve growth factor (NGF) has not yet been examined. In this study, we investigated the effects of an aqueous extract of A. cochinchinensis (AEAC) on the secretion and action mechanism of NGF in neuronal cells. The concentration of the NGF protein in the supernatant collected from cultured cells increased significantly in B35 cells treated with AEAC in comparison with the vehicle-treated group without any specific cytotoxicity. Furthermore, the mRNA expression of NGF showed a very similar pattern to its protein concentration. To examine the bioactivity of NGF secreted from B35 cells, undifferentiated PC12 cells were cultured in an AEAC-conditioned medium and neuritic outgrowth was observed. The dendrite length of PC12 cells in the AEAC-treated group was significantly higher than that in the vehicle-treated group. Moreover, the level of the downstream effectors p-TrkA and p-ERK of the high-affinity NGF receptor was significantly higher in the AEAC-treated group, while the expression of the downstream effectors of the low-affinity NGF receptor was significantly lower in the same group. These results suggest that AEAC may contribute to the regulation of NGF expression and secretion in neuronal cells; it is therefore an excellent candidate for further investigation as a therapeutic drug for neurodegenerative diseases.

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Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Cutaneous inflammation is a common disease that is induced and maintained by the interaction among many cells populations. 3,4 The epidermal and dermal cells are known as the cytokines producers, with keratinocytes being the largest producer of cytokines and adhesion molecules. 5,6 Of the cytokines produced by keratinocytes, only interleukin (IL)-1α, -1β, and tumor necrosis factor (TNF) activate a sufficient number of effector mechanisms to trigger skin inflammation.…”

Section: Introductionmentioning

confidence: 99%

Nanoemulsion as a carrier to improve the topical anti-inflammatory activity of stem bark extract of <em>Rapanea ferruginea</em>

Mas

Zermiani

Thiesen

et al. 2016

IJN

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The aim of this study was to develop nanoemulsion containing soft extract of stem bark of Rapanea ferruginea to improve the topical delivery and anti-inflammatory activity. The extract of R. ferruginea stem bark was incorporated into the oily phase of the nanoemulsion by the method of phase inversion at low energy. The developed nanoemulsion had an average droplet size of 47.88±8.20 nm and a polydispersibility index of 0.228. Uniformity of size, spherical shape of droplet, and absence of clusters were confirmed by transmission electronic microscopy. The zeta potential was −34.7±1.15 mV. The nanoemulsion showed a moderate degree of skin irritation in the agarose overlay assay in vitro. The content of the extract markers, myrsinoic acids A and B, was 54.10±0.08 and 53.03 μg/g in the formulation, respectively. The formulation demonstrated pseudoplastic and thixotropic rheological behavior. In vitro release of chemical markers was controlled by diffusion mechanism. An extract-loaded nanoemulsion showed a topical anti-inflammatory activity in a croton oil-induced edema ear model, with a decrease in tumor necrosis factor release and myeloperoxidase activity. The nanoemulsion was 160% more efficient than the conventional cream containing 0.13% of the extract. The nanoemulsion showed suitable properties as a carrier for topical use of R. ferruginea extract and the approach for improving the topical anti-inflammatory activity.

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Anti-inflammatory effects of Asparagus cochinchinensis extract in acute and chronic cutaneous inflammation

Cited by 9 publications

References 0 publications

Anti-arthritic evaluation of Eclipta alba in a murine model Freund’s adjuvant provoked arthritis

Anti-arthritic evaluation of Eclipta alba in a murine model Freund’s adjuvant provoked arthritis

Effects of an Aqueous Extract of Asparagus cochinchinensis on the Regulation of Nerve Growth Factor in Neuronal Cells

Nanoemulsion as a carrier to improve the topical anti-inflammatory activity of stem bark extract of <em>Rapanea ferruginea</em>

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