Anti-inflammatory effects of a SERP 30 polysaccharide from the residue of Sarcandra glabra against lipopolysaccharide-induced acute respiratory distress syndrome in mice

Qi, Feng; Si, Yu; Zhu, Lijing; Wang, Feng; Fang, Junqiang; Pan, Chun; Gao, Xiangdong; Liu, Wei

doi:10.1016/j.jep.2022.115262

Cited by 6 publications

(4 citation statements)

References 64 publications

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“…Currently, research on EG in the ALI/ARDS field focuses mainly on two avenues: Firstly, it is broadly considered a potential therapeutic target. Several drug candidates have been evaluated for efficacy and safety against EG in animal models, such as Tanshinone IIA ( El-Moslemany et al, 2022 ), SERP 30 polysaccharide ( Feng et al, 2022 ), Crocin ( Zhang et al, 2020 ), and PCTR1(35). These candidates primarily target the expression of EG degradation products, like syndecan-1, or enzymes like HPA.…”

Section: Discussionmentioning

confidence: 99%

Global research progress of endothelial cells and ALI/ARDS: a bibliometric analysis

Zhou,

Long,

Chen

et al. 2024

Front. Physiol.

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BackgroundAcute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe respiratory conditions with complex pathogenesis, in which endothelial cells (ECs) play a key role. Despite numerous studies on ALI/ARDS and ECs, a bibliometric analysis focusing on the field is lacking. This study aims to fill this gap by employing bibliometric techniques, offering an overarching perspective on the current research landscape, major contributors, and emerging trends within the field of ALI/ARDS and ECs.MethodsLeveraging the Web of Science Core Collection (WoSCC) database, we conducted a comprehensive search for literature relevant to ALI/ARDS and ECs. Utilizing Python, VOSviewer, and CiteSpace, we performed a bibliometric analysis on the corpus of publications within this field.ResultsThis study analyzed 972 articles from 978 research institutions across 40 countries or regions, with a total of 5,277 authors contributing. These papers have been published in 323 different journals, spanning 62 distinct research areas. The first articles in this field were published in 2011, and there has been a general upward trend in annual publications since. The United States, Germany, and China are the principal contributors, with Joe G. N. Garcia from the University of Arizona identified as the leading authority in this field. American Journal of Physiology-Lung Cellular and Molecular Physiology has the highest publication count, while Frontiers in Immunology has been increasingly focusing on this field in recent years. “Cell Biology” stands as the most prolific research area within the field. Finally, this study identifies endothelial glycocalyx, oxidative stress, pyroptosis, TLRs, NF-κB, and NLRP3 as key terms representing research hotspots and emerging frontiers in this field.ConclusionThis bibliometric analysis provides a comprehensive overview of the research landscape surrounding ALI/ARDS and ECs. It reveals an increasing academic focus on ALI/ARDS and ECs, particularly in the United States, Germany, and China. Our analysis also identifies several emerging trends and research hotspots, such as endothelial glycocalyx, oxidative stress, and pyroptosis, indicating directions for future research. The findings can guide scholars, clinicians, and policymakers in targeting research gaps and setting priorities to advance the field.

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Section: Discussionmentioning

confidence: 99%

Global research progress of endothelial cells and ALI/ARDS: a bibliometric analysis

Zhou,

Long,

Chen

et al. 2024

Front. Physiol.

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“…S. glabra is renowned for its remarkable anti-inflammatory activities, substantiated by multiple studies reporting its bioactivities in vitro [ 23 – 25 , 37 , 38 , 42 , 48 – 50 , 73 , 82 , 183 – 186 ] and in vivo [ 3 , 187 – 194 ]. The anti-inflammatory properties were found to be imparted by the presence of polysaccharides [ 183 , 193 , 194 ], phenolics [ 3 , 185 ], coumarins [ 3 , 82 , 188 , 189 ], and flavonoids [ 192 ].…”

Section: Biological Activitiesmentioning

confidence: 99%

“…The anti-inflammatory activities of a S. glabra polysaccharide, SERP-30, were reported for the first time by Feng et al [ 193 ]. Corroborated by western blotting results, the postulated mechanism of SERP 30 involves the inhibition of LPS-induced phosphorylation of p38 and p65 via NF-κB and MAPK signalling pathways, leading to the protection of endothelial glycocalyx in LPS induced-acute respiratory distress syndrome (ARDS) in mice.…”

Section: Biological Activitiesmentioning

confidence: 99%

A comprehensive review on the chemical constituents, sesquiterpenoid biosynthesis and biological activities of Sarcandra glabra

Chu,

Krishnan,

Lim

2023

Nat. Prod. Bioprospect.

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Sarcandra glabra (Thunb.) Nakai is a perennial evergreen herb categorised within the Sarcandra Gardner genus under the Chloranthaceae family. Indigenous to tropical and subtropical regions of East Asia and India, this species is extensively distributed across China, particularly in the southern regions (Sichuan, Yunnan, and Jiangxi). In addition to its high ornamental value, S. glabra has a rich history of use in traditional Chinese medicine, evident through its empirical prescriptions for various ailments like pneumonia, dysentery, fractures, bruises, numbness, amenorrhea, rheumatism, and other diseases. Besides, modern pharmacological studies have revealed various biological activities, such as antitumour, anti-bacterial, anti-viral anti-inflammatory and immunomodulatory effects. The diverse chemical constituents of S. glabra have fascinated natural product researchers since the 1900s. To date, over 400 compounds including terpenoids, coumarins, lignans, flavonoids, sterols, anthraquinones, organic acids, and organic esters have been isolated and characterised, some featuring unprecedented structures. This review comprehensively examines the current understanding of S. glabra’s phytochemistry and pharmacology, with emphasis on the chemistry and biosynthesis of its unique chemotaxonomic marker, the lindenane-type sesquiterpenoids. Graphical Abstract

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“…Furthermore, SGN has been widely used in food, medicine, health care products, cosmetics, etc., It has been demonstrated that SGN has great development potential. In addition, several studies have demonstrated that SGN exhibits anti-inflammatory activity ( Liu et al, 2017 ; Tsai et al, 2017 ; Feng et al, 2022 ) and can protect mesenchymal stem cells from OH-induced oxidative stress ( Liu et al, 2016 ). It should be mentioned that mesenchymal stem cells can repair damaged cells, including damaged gastrointestinal mucosal tissue ( Xiang et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Potential of Sarcandra glabra (Thunb.) Nakai. in Treating Ethanol-Induced Gastric Ulcer in Rats Based on Metabolomics and Network Analysis

Wen

Liu

et al. 2022

Front. Pharmacol.

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Gastric ulcer (GU) is one of the most commonly diagnosed diseases worldwide, threatening human health and seriously affecting quality of life. Reports have shown that the Chinese herbal medicine Sarcandra glabra (Thunb.) Nakai (SGN) can treat GU. However, its pharmacological effects deserve further validation; in addition, its mechanism of action is unclear. An acute gastric ulcer (AGU) rat model induced by alcohol was used to evaluate the gastroprotective effect of SGN by analysis of the histopathological changes in stomach tissue and related cytokine levels; the potential mechanisms of action of SGN were investigated via serum metabolomics and network pharmacology. Differential metabolites of rat serum were identified by metabolomics and the metabolic pathways of the identified metabolites were enriched via MetaboAnalyst. Furthermore, the critical ingredients and candidate targets of SGN anti-AGU were elucidated. A compound-reaction-enzyme-gene network was established using Cytoscape version 3.8.2 based on integrated analysis of metabolomics and network pharmacology. Finally, molecular docking was applied to verify the acquired key targets. The results showed that SGN exerted a certain gastroprotective effect via multiple pathways and targets. The effects of SGN were mainly caused by the key active ingredients isofraxidin, rosmarinic, and caffeic acid, which regulate hub targets, such as PTGS2, MAPK1, and KDR, which maintain the homeostasis of related metabolites. Signal pathways involved energy metabolism as well as immune and amino acid metabolism. Overall, the multi-omics techniques were proven to be promising tools in illuminating the mechanism of action of SGN in protecting against diseases. This integrated strategy provides a basis for further research and clinical application of SGN.

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Anti-inflammatory effects of a SERP 30 polysaccharide from the residue of Sarcandra glabra against lipopolysaccharide-induced acute respiratory distress syndrome in mice

Cited by 6 publications

References 64 publications

Global research progress of endothelial cells and ALI/ARDS: a bibliometric analysis

Global research progress of endothelial cells and ALI/ARDS: a bibliometric analysis

A comprehensive review on the chemical constituents, sesquiterpenoid biosynthesis and biological activities of Sarcandra glabra

Assessment of the Potential of Sarcandra glabra (Thunb.) Nakai. in Treating Ethanol-Induced Gastric Ulcer in Rats Based on Metabolomics and Network Analysis

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