Anti-inflammatory effects and acute toxicity of hydroethanolic extract of Jacaranda decurrens roots in adult male rats

Santos, Joyce Alencar; Arruda, Aline; Silva, Magaiver Andrade; Cardoso, Cláudia Andréa Lima; Vieira, Maria do Carmo; Kassuya, Cândida Aparecida Leite; Arena, Arielle Cristina

doi:10.1016/j.jep.2012.10.024

Cited by 29 publications

(26 citation statements)

References 14 publications

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“…These results agree with the earlier studies of the anti-inflammatory activities of some medicinal plants tested against rat paw edema and no toxicity effect as indicated in Trigonella foenum-graecum that possesses an anti inflammatory activity and it was safe at high doses [29]. The same results were found by many researchers [30]- [35]. These findings obtained in the rats paw oedema indicate the anti inflammatory potential of the plant is stronger even than the reference drug indomethacine.…”

Section: Discussionsupporting

confidence: 92%

Safety Assessment and Potential Anti-Inflammatory Effect of Ethanolic Extract of <i>Syzygium aromaticum</i> in Albino Rats

Saeed¹,

Osman²,

Amin³

et al. 2017

ABB

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The present study was undertaken to investigate the effect of the ethanolic extract of Syzygium aromaticum to albino rats. Forty eight Albino rats were employed to test the safety and the anti-inflammatory effect of the extract. Safety of the extract was examined on experimental animal's model at three dose levels of the extract orally in daily doses for three weeks. Effects of S. aromaticum on rats revealed no significant effect on biochemical or haematological parameters. The anti-inflammatory effect of the extract was tested in four equal groups; groups 1 and 2 were treated with 250 and 500 mg/kg of the extract, respectively, group 3 was treated with indomethacine and group 4 was the untreated control. Carrageenan was used as an acute form inducer of inflammation. Indomethacine, the non-steroidal anti-inflammatory drugs (NSAIDs), was used as a reference compound. Oedema size was monitored at the 1 st , 2 nd , 4 th , 6 th and after 24 hours. The ethanolic extract of S. aromaticum showed significant (P < 0.001) decreased in the oedema size at efficacy rates of 79.41%, 82.39% and 63.92% for the dose, 500 mg/kg body weight at the 2 nd , 4 th and 6 th hour respectively higher than that produced by indomethacine.

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Section: Discussionsupporting

confidence: 92%

Safety Assessment and Potential Anti-Inflammatory Effect of Ethanolic Extract of <i>Syzygium aromaticum</i> in Albino Rats

Saeed¹,

Osman²,

Amin³

et al. 2017

ABB

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“…[14] and in the roots of J. decurrens subsp. symmetrifoliolata [15]. The toxicity evaluation of elevated ExJds doses in the present study revealed no signs of toxicity or death among the treated animals.…”

Section: Discussionsupporting

confidence: 42%

“…These results corroborate previous data indicating a lack of toxicity of the roots of J. decurrens subsp. symmetrifoliolata [15]. In addition, some compounds isolated from the same genus showed no toxicity when evaluated alone, such as jacaranone acid isolated from Jacaranda copaia [16].…”

Section: Discussionmentioning

confidence: 99%

Antiobesity Effects of Hydroethanolic Extract of Jacaranda decurrens Leaves

Antunes

Baldivia

Rocha

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Obesity is a worldwide epidemic that reduces life expectancy; therefore, the search for new alternative and effective treatments is ongoing. The aim of the present investigation was to identify the chemical compounds in the hydroethanolic extract of leaves of Jacaranda decurrens subsp. symmetrifoliolata and to evaluate their toxicity and antiobesity effects. High-performance liquid chromatography was used to identify the chemical constituents, and acute toxicity was evaluated in rats treated with doses of 2 and 5 g·kg−1 body mass. The antiobesity effect was determined in rats with hypercaloric diet-induced obesity. Our results revealed the presence of compounds, such as jacaric, ursolic, and oleic acids, as well as luteolin, quercetin, and kaempferol, in the extract. The acute toxicity tests revealed that rats treated with elevated doses of the extract showed no signs of toxicity. The extract induced reduction in total body mass and the white adipose tissue depots. The obese rats treated with the extract showed an increased fluid intake and feces excretion while their serum total cholesterol and triglyceride levels decreased compared to those in the controls, without any hematological changes. Taken together, the results showed that the constituents of J. decurrens extracts included phenolic compounds and exhibited antiobesity effects with no toxicity.

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“…Several pharmaceutical products currently used to treat inflammation are not completely efficient in chronic disease, and can produce several adverse side effects. Therefore, it is necessary to develop more effective agents that are also less toxic [29].…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg

et al. 2016

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Campomanesia xanthocarpa (Myrtaceae) is used in Brazilian traditional medicine against fever, diabetes, hypercholesteremic, obesity, and urinary diseases. In the present study, the compounds 2',6'-dihydroxy-3'-methyl-4'-metoxychalcone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone were identified for the first time in leaves of the C. xanthocarpa. These compounds and the hydroethanolic extract (HECX) significantly inhibited paw edema and reduced both leukocyte migration and the leakage of protein into the pleural cavity. No toxicity was detected by HECX in an acute toxicity test.

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Anti-inflammatory effects and acute toxicity of hydroethanolic extract of Jacaranda decurrens roots in adult male rats

Abstract: The present study shows that Jacaranda decurrens extract has anti-inflammatory properties in rats without causing acute toxicity. These properties observed may be due to the presence of bioactive constituents such as ursolic acid.

Cited by 29 publications

References 14 publications

Safety Assessment and Potential Anti-Inflammatory Effect of Ethanolic Extract of <i>Syzygium aromaticum</i> in Albino Rats

Safety Assessment and Potential Anti-Inflammatory Effect of Ethanolic Extract of <i>Syzygium aromaticum</i> in Albino Rats

Antiobesity Effects of Hydroethanolic Extract of Jacaranda decurrens Leaves

Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg

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Anti-inflammatory effects and acute toxicity of hydroethanolic extract of Jacaranda decurrens roots in adult male rats

Abstract: The present study shows that Jacaranda decurrens extract has anti-inflammatory properties in rats without causing acute toxicity. These properties observed may be due to the presence of bioactive constituents such as ursolic acid.

Cited by 29 publications

References 14 publications

Safety Assessment and Potential Anti-Inflammatory Effect of Ethanolic Extract of &lt;i&gt;Syzygium aromaticum&lt;/i&gt; in Albino Rats

Safety Assessment and Potential Anti-Inflammatory Effect of Ethanolic Extract of &lt;i&gt;Syzygium aromaticum&lt;/i&gt; in Albino Rats

Antiobesity Effects of Hydroethanolic Extract of Jacaranda decurrens Leaves

Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg

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Product

Resources

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Safety Assessment and Potential Anti-Inflammatory Effect of Ethanolic Extract of <i>Syzygium aromaticum</i> in Albino Rats

Safety Assessment and Potential Anti-Inflammatory Effect of Ethanolic Extract of <i>Syzygium aromaticum</i> in Albino Rats