Anti-inflammatory effect of walnut-derived peptide via the activation of Nrf2/Keap1 pathway against oxidative stress

Qi, Yuan; Wu, Dan; Fang, Li; Leng, Yue; Wang, Xiyan; Liu, Chunlei; Liu, Xiaoting; Wang, Ji; Min, Weihong

doi:10.1016/j.jff.2023.105839

Cited by 5 publications

(1 citation statement)

References 33 publications

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“…Walnut meal consists of 40% protein, which contains a notably high content of essential amino acids, making it an excellent source of dietary protein intake [16]. In comparison to walnut protein, its hydrolyzed product, walnut peptides, exhibit superior biological functional properties, such as anti-inflammatory [17], antioxidant [18], antibacterial [19], and neuroprotective effects [20]; furthermore, walnut peptides were confirmed to have a regulatory effect on inflammatory bowel disease (IBD) [21]. However, it is currently unclear whether walnut peptides have a positive impact on damaged gastric mucosal barriers.…”

Section: Introductionmentioning

confidence: 99%

The Gastroprotective Effect of Walnut Peptides: Mechanisms and Impact on Ethanol-Induced Acute Gastric Mucosal Injury in Mice

Yuan,

Wang,

Wang

et al. 2023

Nutrients

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The objective of this research was to explore the protective impact of walnut peptides (WP) against ethanol-induced acute gastric mucosal injury in mice and to investigate the underlying defense mechanisms. Sixty male BALB-c mice were divided into five groups, and they were orally administered distilled water, walnut peptides (200 and 400 mg/kg bw), and omeprazole (20 mg/kg bw) for 24 days. Acute gastric mucosal injury was then induced with 75% ethanol in all groups of mice except the blank control group. Walnut peptides had significant protective and restorative effects on tissue indices of ethanol-induced gastric mucosal damage, with potential gastric anti-ulcer effects. Walnut peptides significantly inhibited the excessive accumulation of alanine aminotransferase (ALT), aspartate transferase (AST), and malondialdehyde (MDA), while promoting the expression of reduced glutathione (GSH), total antioxidant capacity (T-AOC), glutathione disulfide (GSSG), and mouse epidermal growth factor (EGF). Furthermore, the Western blot analysis results revealed that walnut peptides significantly upregulated the expression of HO-1 and NQO1 proteins in the Nrf2 signaling pathway. The defensive impact of walnut peptides on the gastric mucosa may be achieved by mitigating the excessive generation of lipid peroxides and by boosting cellular antioxidant activity.

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Section: Introductionmentioning

confidence: 99%

The Gastroprotective Effect of Walnut Peptides: Mechanisms and Impact on Ethanol-Induced Acute Gastric Mucosal Injury in Mice

Yuan,

Wang,

Wang

et al. 2023

Nutrients

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Structure and regulatory mechanisms of food‐derived peptides in inflammatory bowel disease: A review

Qiu,

Wang,

Liu

et al. 2024

Food Science & Nutrition

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The number of patients with inflammatory bowel disease (IBD) is increasing worldwide. Since IBD is a chronic disease that seriously affects patients' life quality, preventing and alleviating IBD with natural and less side effect substances has become a research hotspot. Food‐derived bioactive peptides have been an attractive research focus due to their high efficiency and low toxicity. This paper comprehensively summarizes food‐derived peptides with intestinal health effects, focusing on peptide sequences with IBD‐regulatory effects and emphasizing the effects of their structure and physicochemical properties such as peptide length, amino acid composition, and net charge on their function. We also analyzed its regulatory mechanisms, mainly in 5 aspects: modulating the intestinal microbiota, decreasing intestinal epithelial permeability, increasing antioxidant ability, regulating the expression of inflammatory cytokines, and targeting signaling pathways. This review will help establish novel, efficient screening methods for IBD‐regulatory peptides and contribute to further research and discovery of them.

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Simulated gastrointestinal digestion of walnut protein yields anti-inflammatory peptides

Xia,

Gao,

Fang

et al. 2024

Food Chemistry

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Anti-inflammatory effect of walnut-derived peptide via the activation of Nrf2/Keap1 pathway against oxidative stress

Cited by 5 publications

References 33 publications

The Gastroprotective Effect of Walnut Peptides: Mechanisms and Impact on Ethanol-Induced Acute Gastric Mucosal Injury in Mice

The Gastroprotective Effect of Walnut Peptides: Mechanisms and Impact on Ethanol-Induced Acute Gastric Mucosal Injury in Mice

Structure and regulatory mechanisms of food‐derived peptides in inflammatory bowel disease: A review

Simulated gastrointestinal digestion of walnut protein yields anti-inflammatory peptides

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