Anti-inflammatory effect of stevioside abates Freund’s complete adjuvant (FCA)-induced adjuvant arthritis in rats

Alavala, Sateesh; Nalban, Nasiruddin; Sangaraju, Rajendra; Kuncha, Madhusudana; Jerald, Mahesh Kumar; Kilari, Eswar Kumar; Sistla, Ramakrishna

doi:10.1007/s10787-020-00736-0

Cited by 35 publications

(30 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This imbalance in the activity of enzymatic antioxidants is corrected with zingerone treatment, thereby indicating antioxidant activity of zingerone in rheumatoid arthritis with decrease in the production of ROS and hence preventing the tissue damage by oxidative stress. These findings are in concurrence with the previous reports of Hemalatha et al [69]; Alvana et al [70], Rao and Rao [71] and Rahmani et al [72] and Saleem et al [73]. The significant reduction in LPO and elevation in antioxidants (SOD, catalase and GPx), in arthritic rats that received zingerone from the day first of rheumatoid arthritis induction, emphasizes the role of zingerone in protecting the organ damage and bone loss in rheumatoid arthritis rat model by scavenging the free radicals.…”

Section: Discussionsupporting

confidence: 94%

Zingerone (4-(four-hydroxy-3-methylphenyl) butane-two-1) modulates adjuvant-induced rheumatoid arthritis by regulating inflammatory cytokines and antioxidants

et al. 2021

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 94%

Zingerone (4-(four-hydroxy-3-methylphenyl) butane-two-1) modulates adjuvant-induced rheumatoid arthritis by regulating inflammatory cytokines and antioxidants

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The results were similar with subsequent reduction in the number of red blood cells in Anti-infammatory effect of stevioside abates Freund's complete adjuvant (FCA)-induced adjuvant arthritis in rats. 18…”

Section: Values Are Expressed As Mean ± Sem N = 6 and Were Estimatedmentioning

confidence: 99%

Haematological Assessment of Methanolic Stem Extract of Cissus quadrangularisLinn. against Freund's Complete Adjuvant induced Female Albino Arthritic Rats

Shamina¹,

Anjana²,

Suja

2022

Int J Life Sci Pharm Res

View full text Add to dashboard Cite

Rheumatoid arthritis is a chronic, inflammatory and autoimmune disorder. Rheumatoid arthritis is a joint destruction which occurs due to increased expression of cytokines and transcription factors. Cissus quadrangularis belongs to the Vitaceae family. The plant shows anti-osteoporotic, anti-inflammatory and anti-microbial properties. Soxhlet method was used for the extraction of the plant using methanol as a solvent. The anti-arthritic activity of methanolic extract of Cissus quadrangularis was evaluated by in vivo study. The present study assess the haematological parameters in female albino rats after the induction of Freund's Complete Adjuvant. Dexamethasone was used as the standard reference drug. The study showed varied changes in the haematology after the arthritic induction by 0.1 ml FCA which were analyzed before and afterthe treatment period. The inhibition of secondary inflammation in adjuvant arthritic rats by methanolic extract of Cissus quadrangularis was studied by haematological parameters. The total haemoglobin, total RBC, total WBC, ESR and RF values were assessed before initiation of the treatment and after for 28 days of the treatment. The results showed significant incline or decline in each parameter in the study period of 28 days. While their changes were rectified with the oral administration of methanolic extract of the plant at a dose of 250mg/kg. The methanolic extract boosted the levels of Hb, RBC and simultaneously reduced WBC, ESR levels along with the serological factor RF. The plant extract showed effective results in the haematological parameters, when compared to the standard reference drug Dexamethasone. The results from the study suggest that the plant has potential effect in curing arthritis.

show abstract

“…Based on the in vitro studies, we then evaluated the in vivo effects of stevioside in a mouse model of LPS-induced excessive cytokine-mediated lethal shock. According to the previous study and the conversion coefficient calculation method, we selected 10, 20, and 40 mg/kg stevioside to be used in our in vivo experiments [10,28]. In our system, mice did not develop lethal shock when given D-GalN alone even up to 15 mg per mouse, while i.p.…”

Section: Stevioside Attenuated the Inflammatory Response And Protectementioning

confidence: 99%

“…Apart from research on the advantages of stevioside compared with traditional food sweeteners, increasing research is focused on the potential pharmacological activities of stevioside [4][5][6][7][8]. Many therapeutic benefits of stevioside have been discovered; it can work as a hypoglycemic, anti-hypertensive, anti-fibrosis, and antiinflammatory [5,6,[8][9][10][11][12][13][14]. A comprehensive evaluation including molecular mechanisms on the anti-inflammatory activity of stevioside has not yet been completed.…”

Section: Introductionmentioning

confidence: 99%

Stevioside Activates AMPK to Suppress Inflammation in Macrophages and Protects Mice from LPS-Induced Lethal Shock

Wei

Zhu

et al. 2021

Molecules

View full text Add to dashboard Cite

Stevioside, a diterpenoid glycoside, is widely used as a natural sweetener; meanwhile, it has been proven to possess various pharmacological properties as well. However, until now there were no comprehensive evaluations focused on the anti-inflammatory activity of stevioside. Thus, the anti-inflammatory activities of stevioside, both in macrophages (RAW 264.7 cells, THP-1 cells, and mouse peritoneal macrophages) and in mice, were extensively investigated for the potential application of stevioside as a novel anti-inflammatory agent. The results showed that stevioside was capable of down-regulating lipopolysaccharide (LPS)-induced expression and production of pro-inflammatory cytokines and mediators in macrophages from different sources, such as IL-6, TNF-α, IL-1β, iNOS/NO, COX2, and HMGB1, whereas it up-regulated the anti-inflammatory cytokines IL-10 and TGF-β1. Further investigation showed that stevioside could activate the AMPK -mediated inhibition of IRF5 and NF-κB pathways. Similarly, in mice with LPS-induced lethal shock, stevioside inhibited release of pro-inflammatory factors, enhanced production of IL-10, and increased the survival rate of mice. More importantly, stevioside was also shown to activate AMPK in the periphery blood mononuclear cells of mice. Together, these results indicated that stevioside could significantly attenuate LPS-induced inflammatory responses both in vitro and in vivo through regulating several signaling pathways. These findings further strengthened the evidence that stevioside may be developed into a therapeutic agent against inflammatory diseases.

show abstract

Anti-inflammatory effect of stevioside abates Freund’s complete adjuvant (FCA)-induced adjuvant arthritis in rats

Cited by 35 publications

References 46 publications

Zingerone (4-(four-hydroxy-3-methylphenyl) butane-two-1) modulates adjuvant-induced rheumatoid arthritis by regulating inflammatory cytokines and antioxidants

Zingerone (4-(four-hydroxy-3-methylphenyl) butane-two-1) modulates adjuvant-induced rheumatoid arthritis by regulating inflammatory cytokines and antioxidants

Haematological Assessment of Methanolic Stem Extract of Cissus quadrangularisLinn. against Freund's Complete Adjuvant induced Female Albino Arthritic Rats

Stevioside Activates AMPK to Suppress Inflammation in Macrophages and Protects Mice from LPS-Induced Lethal Shock

Contact Info

Product

Resources

About