Anti-inflammatory effect of Ruta graveolens L. in murine macrophage cells

Raghav, Sunil K.; Gupta, Bhawna; Agrawal, Charu; Goswami, Kasturi; Das, Hasi R.

doi:10.1016/j.jep.2005.09.008

Cited by 113 publications

(63 citation statements)

References 20 publications

(24 reference statements)

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“…The latter coincided with the amelioration of hepatic necrosis. These findings agree with Raghav et al [36] , who showed a stronger inhibition of iNOS than COX-2 gene expression by rutin in murine macrophages.…”

Section: Discussionsupporting

confidence: 93%

Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice

et al. 2012

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Aim: To investigate the mechanisms underlying the protective effects of quercetin-rutinoside (rutin) and its aglycone quercetin against CCl 4 -induced liver damage in mice. Methods: BALB/cN mice were intraperitoneally administered rutin (10, 50, and 150 mg/kg) or quercetin (50 mg/kg) once daily for 5 consecutive days, followed by the intraperitoneal injection of CCl 4 in olive oil (2 mL/kg, 10% v/v). The animals were sacrificed 24 h later. Blood was collected for measuring the activities of ALT and AST, and the liver was excised for assessing Cu/Zn superoxide dismutase (SOD) activity, GSH and protein concentrations and also for immunoblotting. Portions of the livers were used for histology and immunohistochemistry. Results: Pretreatment with rutin and, to a lesser extent, with quercetin significantly reduced the activity of plasma transaminases and improved the histological signs of acute liver damage in CCl 4 -intoxicated mice. Quercetin prevented the decrease in Cu/Zn SOD activity in CCl 4 -intoxicated mice more potently than rutin. However, it was less effective in the suppression of nitrotyrosine formation. Quercetin and, to a lesser extent, rutin attenuated the inflammation in the liver by down-regulating the CCl 4 -induced activation of nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α) and cyclooxygenase (COX-2). The expression of inducible nitric oxide synthase (iNOS) was more potently suppressed by rutin than by quercetin. Treatment with both flavonoids significantly increased NF-E2-related factor 2 (Nrf2) and heme oxygenase (HO-1) expression in injured livers, although quercetin was less effective than rutin at an equivalent dose. Quercetin more potently suppressed the expression of transforming growth factor-β1 (TGF-β1) than rutin. Conclusion: Rutin exerts stronger protection against nitrosative stress and hepatocellular damage but has weaker antioxidant and antiinflammatory activities and antifibrotic potential than quercetin, which may be attributed to the presence of a rutinoside moiety in position 3 of the C ring.

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Section: Discussionsupporting

confidence: 93%

Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice

et al. 2012

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“…For example: stomachache, vomit, diarrhea, snakebite, wounds, cough, fever, headache, inflammation, nervousness, emmanagogue, abortifacient, anti-inflammatory, anti-spasmodic, anti-helminthic, flu, toothache, body pain, ear pain, etc. 35,36 and more recently As strong antimicrobial. 37 Because of this, the use of plants collected from polluted sites could be a pathway of entrance to human body.…”

Section: Arsenic Concentrations In Shoots and Rootsmentioning

confidence: 99%

Arsenic Concentration in Wild Plants Growing on Two Mine Tailings

Angeles¹,

González-Chávez²,

Scheherazada³

et al. 2015

Phcog Commn.

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Introduction: Plant metalloid contamination may represent an important pathway of Arsenic (As) intake by humans, wild herbivores and livestock. Objective: This study aimed at estimating Arsenic (As) exposition risks to wild plants naturally growing on the contaminated area of Zimapan, Hidalgo, Mexico. Materials and Methods: Arsenic concentrations in the rhizosphere, aerial and root parts, and deposition on leaves of wild plants from two mine tailings were analyzed. Results: The range of total and EDTA-extractable Arsenic (As) concentrations on the mine tailings were from 4016 to17,178 mg kg -1 and from 234 to 499 mg kg -1, respectively. Eleven plant species were the dominant vegetation. Some of these are important in the folk Mexican medicine. Retention of Arsenic (As) in aerial part was between 49 to 7,521 mg kg .6 and 9.6, respectively). Juniperus sp and Ruta graveolens behaved As excluders, while Dalea bicolor accumulated Arsenic (As) close to the maximum tolerate concentrations to animals. After a very drastic washing procedure, leaves still had structural high Arsenic (As) concentration (49-2, 940 mg kg -1 ). Conclusion: This study highlighted that plants are important organism for retaining Arsenic (As) not only on leaves surface but also structurally. Therefore, they strongly influence Arsenic (As) dispersion and risk from mine tailings. Phytoremediation using some of these plants is suggested taking into account control measures to deplete Arsenic (As) transfer to livestock or medicinal herb use.

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“…It is a perennial herb well-known for its anti-leucodermal, anti-inflammatory and anti-cancer properties and is common name is Rue. Rue is native to Europe and also Mediterranean-Balkan Peninsula region and it was brought to Mexico and Tropics of America by Spanish [3]. Rue is also widely distributed in West Indies, Mexico, East Africa (Ethiopia), central South America and India [4,5].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Investigation, Gc-MS Profile and Antimicrobial Activity of a Medicinal Plant Ruta Graveolens L. From Ethiopia

Azalework

Sahabjada

Jafri

et al. 2017

Int J Pharm Pharm Sci

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Objective: This study was designed to screen the phytochemicals present in various solvents extracts of Ruta graveolens (Rue) and furthermore to investigate their antimicrobial activity. Methods:The leaves, stems and seeds of Rue were extracted using four different solvents viz. ethanolic, methanolic, chloroform, and aqueous of varying polarity. The phytochemical screening was carried out qualitatively and Gas Chromatography-Mass Spectroscopy (GC-MS) analysis was performed to identify major phytoconstituents present in the methanolic leaf extract. The antimicrobial effect of extracts was evaluated against six microbial strains namely Bacillus subtillis, Escherichia coli, Proteus vulgaris, Candida albicans, Candida tropicalis and Micrococcus luteus with disc diffusion method.Results: Phytochemical analysis revealed the presence of various secondary metabolites such as flavonoids, alkaloids, terpenoids, saponins and carotenoid. The methanolic leaf extract showed the presence of both tannin and phenolic contents in the higher amount, whereas aqueous extract displayed in the least amount. GC-MS analysis of methanolic leaf extract revealed the presence of approximately 26 phytochemical constituents. The antimicrobial assay revealed that B. subtilis showed a high zone of inhibition (20 mm) at 200 mg/ml of methanolic extract. However, E. coli and C. tropicalis did not show any zone of inhibition against each solvent extract. Conclusion:In conclusion, secondary metabolites present in the extracts have biological activities which warrant further to evaluate in vivo pharmacological studies.

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Anti-inflammatory effect of Ruta graveolens L. in murine macrophage cells

Cited by 113 publications

References 20 publications

Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice

Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice

Arsenic Concentration in Wild Plants Growing on Two Mine Tailings

Phytochemical Investigation, Gc-MS Profile and Antimicrobial Activity of a Medicinal Plant Ruta Graveolens L. From Ethiopia

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