Anti-Inflammatory Effect of Red Piper Crocatum Leaves Extract Decrease TNF-α and IL-6 Levels in Wistar Rat with Atherosclerosis

Wahjuni, Sri; Wita, I Wayan; Astawa, I Nyoman Mantik

doi:10.15562/bmj.v5i2.210

Cited by 8 publications

(8 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Wicaksono et al(2009) reported P. crocatum methanol extract inhibits the growth of human breasts cancer (T47D) cells via inhibition of p44/p42 phosphorylation. Recent study shows P. crocatum leaves extract to act as anti-inflammation in Wistar rats with atherosclerosis through decrease of TNF-and IL-6 levels (Wahjuni et al, 2016). Anti-inflammatory properties of P. crocatum might be correlated with compounds contained in the plants.…”

Section: Discussionmentioning

confidence: 98%

Anti-inflammatory effects of Anredera cordifolia and Piper crocatum extracts on lipopolysaccharide-stimulated macrophage cell line

Laksmitawati

Widyastuti

Karami

et al. 2017

Bangladesh J Pharmacol

View full text Add to dashboard Cite

In this study, the anti-inflammatory potential of Anredera cordifolia and Piper crocatum extracts on lipopolysaccharide-induced murine macrophage cell line (RAW 264.7) was observed. Cell viability assay was performed with MTS assay. Parameters measured to determine the anti-inflammatory activity were interleukin-1β (IL-1β), tumor necrosis factor (TNF)-α, nitric oxide (NO) and IL-6. Both A. cordifolia and P. crocatum at concentration of 50 µg/mL in cell line resulted significant decrease in TNF-α level (250.3 and 242.5 pg/mL respectively). A. cordifolia showed significant decrease in IL-1β level at 50 µg/mL and IL-6 level at 10 µg/mL, whilst P. crocatum showed significant decrease IL-1β level in three concentrations with lowest level at 50 µg/mL. A. cordifolia showed lowest decrease in NO level at 50 µg/mL but not comparable with normal cells, whilst P. crocatum showed significant decrease in NO level at 50 µg/mL. This research revealed that A. cordifolia and P. crocatum possess the anti-inflammatory potential indicated by the inhibitory activity of the inflammatory mediators including, TNF-α, IL-1β, IL-6, and NO.

show abstract

Section: Discussionmentioning

confidence: 98%

Anti-inflammatory effects of Anredera cordifolia and Piper crocatum extracts on lipopolysaccharide-stimulated macrophage cell line

Laksmitawati

Widyastuti

Karami

et al. 2017

Bangladesh J Pharmacol

View full text Add to dashboard Cite

show abstract

“…The role of endoglin in this context is of particular interest [17][18][19][20]. Macrophages play a crucial role in the development of atherosclerosis, which can be triggered by endothelial dysfunction, hypertension, vasculitis, aortic aneurysm, or other vascular disorders [21,22]. The polarization and accumulation of macrophages in a chronic pro-inflammatory state can lead to significant and irreversible vascular damage, affecting clinical outcomes [23].…”

Section: Hypoxiamentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

View full text Add to dashboard Cite

Background:The utilization and advancement of hyperbaric science continue to evolve, encompassing the investigation of cardiovascular disease. Macrophage activation stimulates the expression of matrix metalloproteinases, specifically MMP-12, which play a crucial role in atherosclerosis by influencing vascular tissue. Methods: This study aimed to examine MMP-12 expression in cardiovascular disease induced by an atherogenic high-fat diet and explore the effects of hyperbaric oxygen therapy. Previous research has focused on the primary mechanism of hyperbaric oxygen therapy through the SIRT1 (Sirtuin) pathway, which addresses endothelial dysfunction in atherosclerosis treatment. However, the impact of HBO utilization on the treatment and prevention of cardiovascular disease remains unexplored. Results: Molecular analysis of MMP-12 was conducted using a rat model administered a high-fat diet, followed by HBO treatment. Endothelial dysfunction caused by the high-fat diet was identified as a marker of cardiovascular disease, assessed by endothelin-1 (ET-1) levels. The administration of hyperbaric oxygen (HBO) yielded significant improvements in atherosclerosis and heart disease. The results, with a pvalue of 0.05, were significant for both the treatment and prevention of atherosclerotic heart disease in the two groups used as models. Conclusion: Sprague Dawley rats subjected to hyperbaric oxygen therapy at a pressure of 2.4 ATA, three sessions of 30 minutes each, for ten consecutive days, demonstrated potential for application in cardiovascular disease prevention and treatment.

show abstract

“…The studies cited above report the traditional use of this species, P. aleyreanum, as immunomodulatory, analgesic and antidepressant (Brait et al, 2015); people use it empirically in a more general way for bronchitis, intestinal pain, skin irritations and inflammation treatment (Lima et al, 2012). Wahjuni et al (2016) and Laksmitawati et al (2017) performed tests with P. crocatum. Both evidenced the reduction of serum levels of TNF-α, IL-1, IL-6, and NO in Wistar rats and in LPS-induced macrophage cells, respectively.…”

Section: Leaves Dichloromethane Extractmentioning

confidence: 99%

Systematic review: Medicinal use and scientific elucidation of the Piper genus for the treatment of symptoms and inflammatory diseases

Lima¹,

Lima²,

Correia³

et al. 2020

J. Med. Plants Res.

View full text Add to dashboard Cite

The aim of this study was to conduct a systematic review that reported the medicinal use of the genus Piper, and pharmacological elucidations for the treatment of symptoms and processes of inflammation and inflammatory diseases. The systematic review was prepared in accordance with PRISMA guidelines. The databases used for this research were the Web of Science and Scopus, where associations with the terms were applied in both databases: "Piper" and "Ethnobotanical" and "Piper" and "Anti-inflammatory effect". Initially, the research identified 153 articles, of which 24 articles were selected for final analysis following the inclusion criteria. The results indicate that the medicinal use of species of the Piper genus entails mainly using of leaves, roots, and fruits, and decoct, maceration and powder for the treatment of inflammatory and respiratory diseases such as asthma and bronchitis. Regarding the evaluation of the anti-inflammatory effect of the genus, only seven species presented studies with their scientifically proven anti-inflammatory effect. Biases in the methodology applied in the studies were observed. In this systematic review, it was noticed that both studies addressed have gaps that can cause damage to future research and that pharmacological studies for inflammation with the use of the species themselves are still limited, with a more job for the isolated compounds of these plants.

show abstract

Anti-Inflammatory Effect of Red Piper Crocatum Leaves Extract Decrease TNF-α and IL-6 Levels in Wistar Rat with Atherosclerosis

Cited by 8 publications

References 1 publication

Anti-inflammatory effects of <i>Anredera cordifolia</i> and <i>Piper crocatum</i> extracts on lipopolysaccharide-stimulated macrophage cell line

Anti-inflammatory effects of <i>Anredera cordifolia</i> and <i>Piper crocatum</i> extracts on lipopolysaccharide-stimulated macrophage cell line

Untitled

Systematic review: Medicinal use and scientific elucidation of the Piper genus for the treatment of symptoms and inflammatory diseases

Contact Info

Product

Resources

About