Anti-inflammatory effect of O-methylated flavonol 2-(3,4-dihydroxy-phenyl)-3,5-dihydroxy-7-methoxy-chromen-4-one obtained from Cassia sophera Linn in rats

Experimental immunology Rhamnetin attenuates cognitive deficit and inhibits hippocampal inflammatory response and oxidative stress in rats with traumatic brain injury

“…The results indicate that rhamnetin could inhibit the hippocampal inflammatory response in TBI rats, and that the effect was dose dependent. The findings were consistent with previous studies that reported the anti-inflammatory effects of rhamnetin [17–19]. The inhibition of the inflammatory response by rhamnetin should play a role in the improvement of the cognitive function in TBI rats.…”

“…Nonetheless, limited effective methods in treating the cognitive deficit induced by TBI are available in clinics. Rhamnetin is a phenolic flavonoid compound possessing various pharmacological activities, such as cardioprotective, anti-inflammatory, anti-oxidative, and anti-apoptotic effects [17–19, 22]. In order to detect the possible effects of rhamnetin on the cognitive deficit induced by TBI, we established a TBI rat model using a pneumatic cortical contusion device as described previously, the use of which can be seen extensively in literature [20].…”

“…Rhamnetin, a phenolic flavonoid compound, has been used to manage some disorders in animal models. Recently, it was shown to have anti-inflammatory and anti-oxidative activities in some cell and animal models, such as in B16 cells, mouse macrophage-derived RAW264.7 cells, and in rats with paw oedema [17–19]. However, its activity in animal models of TBI has not been investigated, and its effect on cognitive deficit caused by TBI is unknown to date.…”

Assessment of anti-diabetic activity of <i>Cassia sophera</i> (Caesalpiniaceae)

“…It is 1 -3 m tall with compound leaves consisting of 4 -12 pairs of leaflets. The ethnomedicinal reputation of this plant includes its use in treatment of diabetes, rheumatic disorders, constipation, bronchitis, asthma and liver diseases [7]. It is considered to possess anticancer and anti-inflammatory properties.…”

Rhamnetin Attenuates Melanogenesis by Suppressing Oxidative Stress and Pro-inflammatory Mediators

“…10,11) Many natural phenolic compounds have been reported as melanogenesis inhibitors. [10][11][12][13] Although rhamnetin, a phenolic flavonoid compound, is known to function as an antioxidant 14) and alkylperoxyl radical-scavenging, 15) anti-inflammatory, 16) xanthine oxidase inhibitory 17) and antiviral agent, 18) its protective action against melanogenesis, oxidative stress, and inflammatory mediators has not been fully elucidated to date.…”