Anti‐inflammatory effect of <i>Ishige okamurae</i> ethanolic extract via inhibition of NF‐<i>κ</i>B transcription factor in RAW 264.7 cells

Kim, Moon‐Moo; Rajapakse, Niranjan; Kim, Se‐Kwon

doi:10.1002/ptr.2674

Cited by 65 publications

(38 citation statements)

References 27 publications

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“…The efficacies of I. okamurae (Kim K.N. et al, 2009;Kim M.M. et al, 2009), S. thunbergii (Samee et al, 2009) and G. furcata (Bae and Choi, 2007) extracts have already been reported.…”

Section: Resultsmentioning

confidence: 88%

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Inhibitory effect of Jeju endemic seaweeds on the production of pro-inflammatory mediators in mouse macrophage cell line RAW 264.7

Yang

Moon

Kim

et al. 2010

J. Zhejiang Univ. Sci. B

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Seaweed has been used in traditional cosmetics and as a herbal medicine in treatments for cough, boils, goiters, stomach ailments, and urinary diseases, and for reducing the incidence of tumors, ulcers, and headaches. Despite the fact that seaweeds are frequently used in the practice of human health, little is known about the role of seaweed in the context of inflammation. This study aimed to investigate the influence of Jeju endemic seaweed on a mouse macrophage cell line (RAW 264.7) under the stimulation of lipopolysaccharide (LPS). Ethyl acetate extracts obtained from 14 different kinds of Jeju seaweeds were screened for inhibitory effects on pro-inflammatory mediators. Our results revealed that extracts from five seaweeds, Laurencia okamurae, Grateloupia elliptica, Sargassum thunbergii, Gloiopeltis furcata, and Hizikia fusiformis, were potent inhibitors of the production of pro-inflammatory mediators such as nitric oxide (NO), prostaglandin E 2 (PGE 2 ), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). Based on these results, the anti-inflammatory effects and low cell toxicity of these seaweed extracts suggest potential therapeutic applications in the regulation of the inflammatory response.

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“…The efficacies of I. okamurae (Kim K.N. et al, 2009;Kim M.M. et al, 2009), S. thunbergii (Samee et al, 2009) and G. furcata (Bae and Choi, 2007) extracts have already been reported.…”

Section: Resultsmentioning

confidence: 88%

“…Therefore, in response to this unusual environment, the seaweeds that are present on Jeju Island may possess substantial endogenous protective mechanisms (Kim K.N. et al, 2009;Kim M.M. et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of Jeju endemic seaweeds on the production of pro-inflammatory mediators in mouse macrophage cell line RAW 264.7

Yang

Moon

Kim

et al. 2010

J. Zhejiang Univ. Sci. B

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“…(12,13) Recently, it was reported that anti-inflammatory activity of ethanol fraction of Ishige okamurae (brown algae) was exhibited through the inhibition of NF-κB transcription factor in RAW264.7 cells. (14) As a part of our ongoing search for finding new anti-inflammatory compounds from marine sponges, we found that the ethylacetate extracts of Cliona celata (ECC) inhibited LPS-stimulated NO production in RAW264.7 cells. Although some biologically active compounds such as glyconectins and proteoglycan and autophagy-modulating aminosteroids were isolated from this sponge, any information about the effect of ECC extract as anti-inflammation has not been reported until now.…”

Section: Research Articlementioning

confidence: 99%

Anti-inflammatory activity of ethylacetate fraction ofCliona celata

Yang

Suh

et al. 2010

Immunopharmacology and Immunotoxicology

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We evaluated the ability of the ethylacetate fraction of marine sponge, Cliona celata (ECC), harvested from Korean seaside to regulate the expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated murine macrophage-like RAW264.7 cells. ECC dose-dependently inhibited both the expression of iNOS protein and mRNA, resulting in decreased production of nitric oxide (NO), with an IC(50) of 80.5 μg/mL. To investigate action mechanism by which ECC inhibits NO production and iNOS expression, we examined the activation of IκB in LPS-stimulated RAW264.7 cells. ECC clearly inhibited translocation of nuclear factor-κB (NF-κB) p65 subunits from cytosol to nucleus, which correlated with its inhibitory effects on IκB-α phosphorylation and degradation. Furthermore, ECC potently suppressed both the reporter gene expression and DNA-binding activity of NF-κB, which was associated with decreased p65 protein levels in the nucleus. Here, we show for the first time that ECC inhibits NF-κB activation through the inhibition of IκB degradation.

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“…Fucoidan has been reported to inhibit the growth of a wide range of tumor cells [43,46]. It has also been shown to induce apoptosis in colon cancer HT-29 and HCT116 cells in a dose-dependent manner [15,49]. Kim et al .…”

Section: Seaweed and Colorectal Cancermentioning

confidence: 99%

Anticancer Effects of Different Seaweeds on Human Colon and Breast Cancers

et al. 2014

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Seafoods and seaweeds represent some of the most important reservoirs of new therapeutic compounds for humans. Seaweed has been shown to have several biological activities, including anticancer activity. This review focuses on colorectal and breast cancers, which are major causes of cancer-related mortality in men and women. It also describes various compounds extracted from a range of seaweeds that have been shown to eradicate or slow the progression of cancer. Fucoidan extracted from the brown algae Fucus spp. has shown activity against both colorectal and breast cancers. Furthermore, we review the mechanisms through which these compounds can induce apoptosis in vitro and in vivo. By considering the ability of compounds present in seaweeds to act against colorectal and breast cancers, this review highlights the potential use of seaweeds as anticancer agents.

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Anti‐inflammatory effect of Ishige okamurae ethanolic extract via inhibition of NF‐κB transcription factor in RAW 264.7 cells

Cited by 65 publications

References 27 publications

Inhibitory effect of Jeju endemic seaweeds on the production of pro-inflammatory mediators in mouse macrophage cell line RAW 264.7

Inhibitory effect of Jeju endemic seaweeds on the production of pro-inflammatory mediators in mouse macrophage cell line RAW 264.7

Anti-inflammatory activity of ethylacetate fraction ofCliona celata

Anticancer Effects of Different Seaweeds on Human Colon and Breast Cancers

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