Anti-inflammatory effect of flavonoids isolated from Korea Citrus aurantium L. on lipopolysaccharide-induced mouse macrophage RAW 264.7 cells by blocking of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathways

Kang, Sang Rim; Park, Kwang Il; Park, Ki-Soo; Lee, Dong Hoon; Kim, Jin A; Nagappan, Arulkumar; Kim, Eun Hee; Lee, Won Sup; Shin, Sung Chul; Park, Moon Ki; Han, Dae Yong; Kim, Gon Sup

doi:10.1016/j.foodchem.2011.06.039

Cited by 104 publications

(67 citation statements)

References 30 publications

(29 reference statements)

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“…However, in another similar cellular model, a flavonoid fraction (nobiletin, naringin, and Hsd) that was isolated from Korean Citrus aurantium L. considerably suppressed the pro‐inflammatory enzyme of COX‐2 at both the mRNA and protein level as well as the pro‐inflammatory cytokines. It should be noted that the flavonoids were tested as a mixture in this study; thus, the observed effects are related to the total mixture rather than to each flavonoid distinctly (Kang et al ., ). Jeon et al .…”

Section: Anti‐inflammatory Effectsmentioning

confidence: 97%

Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models

et al. 2014

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Inflammation and oxidative stress are two major causes of various life-threatening diseases. Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species that have numerous biological properties, particularly antioxidant and anti-inflammatory. New findings showed that the antioxidant activity of Hsd/Hst was not only limited to its radical scavenging activity, but it augmented the antioxidant cellular defenses via the ERK/Nrf2 signaling pathway as well. Various in vitro and in vivo studies have been conducted to evaluate Hsd, its metabolites, or its synthetic derivatives at reducing inflammatory targets including NF-κB, iNOS, and COX-2, and the markers of chronic inflammation. In this review, new findings regarding the molecular targets of Hsd and Hst in the reduction of oxidative stress are discussed. Also, in the anti-inflammatory section, we provide a summary of significant investigations concerning the mechanisms of action based on the studied inflammation models.

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Section: Anti‐inflammatory Effectsmentioning

confidence: 97%

Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models

et al. 2014

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“…17 The effect was found to be instantaneous and was attributed to its ability to directly scavenge radicals. Oxidative stress was induced to endothelial cells by addition of Kang et al 18 found that three flavonoids isolated from bitter oranges, namely nobiletin, naringin and hesperidin, also displayed anti-inflammatory properties when administered to LPS-stimulated murine macrophage cells.…”

Section: Lemmens Et Al Found That 7-mono-o-(-hydroxyethyl)-rutoside Amentioning

confidence: 99%

Flavonoids – Small Molecules, High Hopes

Sandu¹,

Birsa

Bahrin

2017

Acta Chemica Iasi

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This brief review takes a look at flavonoids, a wide class of polyphenols, which are regarded as plant secondary metabolites. Their roles in plants are diverse and little understood. They can act as growth hormone modulators, phytoalexins, they offer UV protection, contribute to pollen viability and can function as signaling molecules in establishing symbiotic relationships. Flavonoids were also found to have a range of beneficial effects for the human body. Their anticancer, antioxidant, anti-inflammatory and cardioprotective activity, as well as their antibacterial, antiviral and antihelmintic properties make them promising candidates for the design of new drugs.

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“…Cytokines produced at appropriate levels against a pathogen infection can be beneficial to the host, but the overexpression of these cytokines can cause serious diseases. Normal inflammatory responses are self-limited by a process that involves the down-regulation of pro-inflammatory mediators and an increase in anti-inflammatory mediators [3]. However, the response of a cell to an increase in oxidants or inflammatory stimuli often involves the activation of numerous intracellular signaling pathways.…”

Section: Introductionmentioning

confidence: 99%

The Anti-Inflammatory and Vasodilating Effects of Three Selected Dietary Organic Sulfur Compounds from Allium Species

Chu

Shieh

et al. 2017

JFB

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The anti-inflammatory and vasodilating effects of three selected dietary organic sulfur compounds (OSC), including diallyl disulfide (DADS), dimethyl disulfide (DMDS), and propyl disulfide (PDS), from Allium species were investigated. In the anti-inflammatory activity assay, the three OSC demonstrated significant inhibition of nitric oxide (NO) and prostaglandin E2 (PGE2) production in LPS-induced RAW 264.7 cells. The expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) in activated RAW 264.7 cells was inhibited by the three OSC, indicating that the three OSC prevented the LPS-induced inflammatory response in RAW 264.7 cells. For the vasodilative assay, the three OSC were ineffective in producing NO in SVEC4-10 cells, but they did enhance prostacyclin (PGI2) production. The expression of COX-2 in SVEC4-10 cells was activated by DADS and DMDS. Pretreatment of SVEC4-10 cells with the three OSC decreased ROS generation in H2O2-induced SVEC4-10 cells. In addition, the three OSC significantly inhibited angiotensin-I converting enzyme (ACE). The up-regulation of PGI2 production and COX-2 expression by DADS and DMDS and the reduction of ROS generation by DADS, DMDS, and PDS in SVEC4-10 cells contributed to the vasodilative effect of the three OSC. Collectively, these findings suggest that DADS, DMDS, and PDS are potential anti-inflammatory and vasodilative mediators.

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Anti-inflammatory effect of flavonoids isolated from Korea Citrus aurantium L. on lipopolysaccharide-induced mouse macrophage RAW 264.7 cells by blocking of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathways

Cited by 104 publications

References 30 publications

Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models

Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models

Flavonoids – Small Molecules, High Hopes

The Anti-Inflammatory and Vasodilating Effects of Three Selected Dietary Organic Sulfur Compounds from Allium Species

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