Anti-inflammatory effect of ethanolic extract of spine, skin and rind of Jack fruit peel – A comparative study

Meera, Modak; Ruckmani, A.; Saravanan, R; Prabhu, R Lakshmipathy

doi:10.1080/14786419.2017.1378200

Cited by 21 publications

(12 citation statements)

References 10 publications

(4 reference statements)

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“…Various epidemiological studies conducted on human have confirmed that antioxidants extracted from jackfruit can prevent gastric cancer, lung cancer, prostate cancer, coronary heart disease, myocardial infarction, hypertension etc. [3][4][5]. Both the seeds and pulp of jackfruit are edible.…”

Section: Introductionmentioning

confidence: 99%

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Response Surface Optimization for Antioxidant Extraction from Jackfruit (<i>Artocarpus heterophyllus</i> Lam.) Seed and Pulp

et al. 2020

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The maximum yield of antioxidant activity of freeze-dried jackfruit seeds and pulps was optimized in experimental conditions using response surface methodology. Temperature (°C), time (min) and solvent types (mL) were selected as three independent variables. DPPH (2,2-diphenyl-1-picrylhydrazyl radical), TPC (total phenolic content) and FRAP (ferric reducing antioxidant power) were considered for the antioxidant activity. DPPH, TPC and FRAP values of seed ranged from 45-67.90 %, 2.27-5.42 mg GAE/100 g DM and 63.30-156.39 mg AAE/100 g DM, respectively while those of pulp were 49-72.14 %, 2.109-5.02 mg GAE/100 g DM and 54.90-298.00 mg AAE/100 g DM respectively. The response surface optimization revealed that the optimum conditions for maximum antioxidant activity in seeds were at 65 °C, 10 min and acetone as solvent with 8.76 % DPPH, 2.81 mg GAE/100 g DMTPC, 149.99 mg AAE/100 g DM FRAP and 0.99 desirability whereas that of pulp were at 50°C, 10 min and acetone as solvent with 45.42 % DPPH, 3.06 mg GAE/100 g DMTPC, 129.05 mg AAE/100 g DM FRAP and 0.99 desirability. Extraction of antioxidants from jackfruit seed and pulp can be performed more efficiently up to the maximum yield by maintaining the optimum conditions pinpointed in this study.

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Section: Introductionmentioning

confidence: 99%

“…The ethanolic extraction for jackfruit seed and pulp describing a full 23 factorial experimental design along with corresponding responses.To conduct the experimental design and the statistical analysis, well-known software package R (version 2.14.1) was used in this study. All the tests of statistical significance were based on.…”

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confidence: 99%

Response Surface Optimization for Antioxidant Extraction from Jackfruit (<i>Artocarpus heterophyllus</i> Lam.) Seed and Pulp

et al. 2020

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“…TIR domain proteins and RLP33 are well known for foreign pattern recognition and providing immunity to plants from microbes (Burch-Smith and Dinesh-Kumar, 2007; Jamieson et al, 2018). In addition, the two most essential genes of the Flavanoid Biosynthesis Pathway, Chalcone Synthase (CHS) and Flavanone 3-Hydroxylase (F3H) have lineage-specific gene copies and may explain the high flavonoid content of A. heterophyllus (Meera et al, 2018). ASMT (N-Acetylserotonin Methyltransferase) and COMT (Caffeic Acid O-methyltransferase) genes act in the penultimate step of the melatonin pathway (Back et al, 2016; Zhao et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

Jack of all trades: genome assembly of Wild Jack and comparative genomics of Artocarpus

Patil

Vajja

Raghavendra

et al. 2022

Preprint

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Known as breadfruits for their diverse nutritious fruits, the Artocarpus (Moraceae) genus is prized for its high-quality timber, medicinal value, and economic importance. Breadfruits are native to Southeast Asia but have been introduced to other continents. The most commonly cultivated species are Artocarpus heterophyllus (Jackfruit) and Artocarpus altilis (Breadfruit). With numerous smaller but nutritionally comparable fruits on a large tree, Artocarpus hirsutus, also called "Wild jack" or "Ayani" is an elusive forest species endemic to Indian Western Ghats. In this study, we sequenced and assembled the whole genome of Artocarpus hirsutus sampled from sacred groves of Coorg, India. We compared our Wild jack genome with previously published Jackfruit and Breadfruit genomes to decipher demography and evolution. Demographic history reconstruction indicates a stronger effect of habitat rather than phylogeny on the population histories of these plants. Repetitive genomic regions, especially LTR Copia, strongly affected the demographic trajectory of A. heterophyllus. Upon further investigation, we found a recent lineage-specific accumulation of LTR Copia in A. heterophyllus, which results in its larger genome size. Gene family evolution and signatures of selection identified multiple genes from starch, sucrose metabolism, plant hormone signal transduction, etc., in Artocarpus species. Our comparative genomic framework provides important insights by incorporating endemic species such as the Wild jack.

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“…Artocarpanone and artocarpin strongly inhibited myeloperoxidase activity of human phagocytes with an IC 50 value of 23.3 μm and have potential to be developed into potent anti-in lammatory agents [23]. Meera, et al [24] studied the anti-in lammatory effect of ethanolic extracts of spine, skin and rind of jack fruit. The results revealed that skin extract exhibited maximum anti-in lammatory activity, rind had preferential inhibition on Cyclooxygenase-2 and spine and skin inhibited both Cyclooxygenase-1 and 2 in vitro.…”

Section: Anti-infl Ammatorymentioning

confidence: 99%

Chemical constituents and biological activities of Artocarpus heterophyllus lam (Jackfruit): A review

Bhad¹,

Bobde²,

Sibi³

2021

Int J Clin Microbiol Biochem Technol

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Artocarpus (Moraceae) is a deciduous tree with appreciable importance as a source of edible fruit and is widely used in folk medicines. The extracts and metabolites of Artocarpus heterophyllus particularly those from leaves, bark, stem and fruit possess several useful bioactive compounds. This review indents to compile various studies on A. heterophyllus and critically evaluates its ethnomedical and ethnopharmacological properties. Several pharmacological studies from A. heterophyllus have conclusively established their mode of action in anti-inflammatory, antimicrobial, antioxidant and anticancer activities. Based on the available data, it is concluded that Artocarpus as a promising source of useful products and opens up new avenues for novel therapeutics.

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Anti-inflammatory effect of ethanolic extract of spine, skin and rind of Jack fruit peel – A comparative study

Cited by 21 publications

References 10 publications

Response Surface Optimization for Antioxidant Extraction from Jackfruit (<i>Artocarpus heterophyllus</i> Lam.) Seed and Pulp

Response Surface Optimization for Antioxidant Extraction from Jackfruit (<i>Artocarpus heterophyllus</i> Lam.) Seed and Pulp

Jack of all trades: genome assembly of Wild Jack and comparative genomics of Artocarpus

Chemical constituents and biological activities of Artocarpus heterophyllus lam (Jackfruit): A review

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