Anti-inflammatory effect of dexmedetomidine combined with hypothermia on acute respiratory distress syndrome in rats

Chen, Xianfeng; Li, Lili; Hu, Juntao; Zhang, Chi; Pan, Yiping; Tian, Diansheng; Tang, Zhanhong

doi:10.1016/j.jss.2017.05.014

Cited by 10 publications

(8 citation statements)

References 25 publications

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“…Dexmedetomidine (Dex) is a highly selective α 2 -adrenergic receptor agonist that is commonly used as a sedative and analgesic in the intensive care unit (24); it has been reported to display synergistic effects with hypothermia (25,26). Consequently, based on previous observations that hypothermia can alleviate neuronal damage following CA, it was hypothesized in the present study that Dex administration after CA may result in improved neural function and reduced apoptosis and autophagy.…”

Section: Introductionmentioning

confidence: 94%

Hypothermic properties of dexmedetomidine provide neuroprotection in rats following cerebral ischemia‑reperfusion injury

Liu

Zhu

et al. 2019

Exp Ther Med

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Dexmedetomidine (Dex) is a sedative and analgesic agent that is widely administered to patients admitted to the intensive care unit, and has been demonstrated to result in hypothermia. Many patients have been revealed to benefit from therapeutic hypothermia, which can mitigate cerebral ischemia/reperfusion (I/R) injury following successful cardiopulmonary resuscitation. However, studies investigating the efficacy of Dex in I/R treatment is lacking. The present study aimed to investigate the efficacy of Dex in mitigating neuronal damage, and to determine the possible mechanism of its effects in a rat model of cardiac arrest (CA). CA was induced in Sprague-Dawley rats by asphyxiation for 5 min. Following successful resuscitation, the surviving rats were randomly divided into two treatment groups; one group was intraperitoneally administered with Dex (D group), whereas the control group was treated with normal saline (N group). Critical parameters, including core temperature and blood pressure were monitored following return of spontaneous circulation (ROSC). Arterial blood samples were collected at 10 min after surgery (baseline) 30 and 120 min post-ROSC; and neurological deficit scores (NDS) of the rats were taken 12 or 24 h after ROSC prior to euthanasia. The hippocampal tissue was then removed for analysis by histology, electron microscopy and western blotting. Rats in the D group exhibited a lower core temperature and higher NDS scores compared with the N group (P<0.05). In addition, Dex injection resulted in reduced expression of apoptotic and autophagy-associated factors in the hippocampus (P<0.05). Dex treatment induced hypothermia and improved neurological function in rats after ROSC following resuscitation from CA by inhibiting neuronal apoptosis and reducing autophagy, which suggested that Dex may be a potential therapy option for patients with CA.

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Section: Introductionmentioning

confidence: 94%

Hypothermic properties of dexmedetomidine provide neuroprotection in rats following cerebral ischemia‑reperfusion injury

Liu

Zhu

et al. 2019

Exp Ther Med

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“…Therapeutic hypothermia has widely recommended in the standard of care for neonates with HIE 11 . The mechanisms underlying hypothermia's protective effects are complex and it is thought to attenuates secondary injury of inflammation, decreases vasogenic edema and hemorrhage, prevents neutrophil infiltration, decreases apoptosis and prevents free oxygen radical production 12,13 . Most of the interest focused on brain function and relatively little information has been gained on the effect of therapeutic hypothermia on other body organs and more so on the lungs 14 .…”

Section: ■ Introductionmentioning

confidence: 99%

Effects of hypothermia on lung inflammation in a rat model of meconium aspiration syndrome

2018

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1 2-Experimental SurgeryActa Cir Bras. 2018;33(6):483-490 AbstractPurpose: To evaluate the effects of hypothermia treatment on meconium-induced inflammation. Methods: Fifteen rats were instilled with human meconium (MEC, 1.5 mL/kg, 65 mg/mL) intratracheally and ventilated for 3 hours. Eight rats that were ventilated and not instilled with meconium served as a sham group. In MEC-hypothermia group, the body temperature was lowered to 33±0.5°C. Analysis of the blood gases, interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α in bronchoalveolar lavage (BAL) fluid samples, and histological analyses of the lungs were performed. Results: The BAL fluid TNF-α, IL-1β, IL-6 and IL-8 concentrations were significantly higher in the MEC-hypothermia group than in the MEC-normothermia (p < 0.001, p < 0.001, p = 0.001, p < 0.001, respectively) and sham-controlled groups (p < 0.001, p < 0.001, p < 0.001, p < 0.001, respectively). Conclusion: Meconium-induced inflammatory cytokine production is affected by the body temperature control.

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“…Arterial blood gas analysis is one of the most useful techniques for measuring acid-base equilibria in human and animal subjects. 5 6 This respiratory monitoring technique permits the measurement of pH, partial pressures of oxygen and carbon dioxide (pO 2 and pCO 2 ), oxygen saturation (SatO 2 ), hemoglobin content, total carbon dioxide (TCO 2 ), and bicarbonate concentrations [HCO 3 – ] in a sample of arterial blood. 7 Using arterial blood gas analysis, we sought to determine the acid-base equilibrium responses in male Wistar rats before and after intravenous administration of Cytoreg.…”

Section: Introductionmentioning

confidence: 99%

Effect of an ionic antineoplastic agent Cytoreg on blood chemistry in a Wistar rat model

et al. 2022

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Cytoreg is an ionic therapeutic agent comprising a mixture of hydrochloric, sulfuric, phosphoric, hydrofluoric, oxalic, and citric acids. In diluted form, it has demonstrated efficacy against human cancers in vitro and in vivo . Although Cytoreg is well tolerated in mice, rats, rabbits, and dogs by oral and intravenous administration, its mechanism of action is not documented. The acidic nature of Cytoreg could potentially disrupt the pH and levels of ions and dissolved gases in the blood. Here, we report the effects of the intravenous administration of Cytoreg on the arterial pH, oxygen and carbon dioxide pressures, and bicarbonate, sodium, potassium, and chloride concentrations. Our results demonstrate that Cytoreg does not disturb the normal blood pH, ion levels, or carbon dioxide content, but increases oxygen levels in rats. These data are consistent with the excellent tolerability of intravenous Cytoreg observed in rabbits, and dogs. The study was approved by the Bioethics Committee of the University of the Andes, Venezuela (CEBIOULA) (approval No. 125) on November 3, 2019.

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Anti-inflammatory effect of dexmedetomidine combined with hypothermia on acute respiratory distress syndrome in rats

Cited by 10 publications

References 25 publications

Hypothermic properties of dexmedetomidine provide neuroprotection in rats following cerebral ischemia‑reperfusion injury

Hypothermic properties of dexmedetomidine provide neuroprotection in rats following cerebral ischemia‑reperfusion injury

Effects of hypothermia on lung inflammation in a rat model of meconium aspiration syndrome

Effect of an ionic antineoplastic agent Cytoreg on blood chemistry in a Wistar rat model

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