Anti-Inflammatory Effect of Crocus sativus on Serum Cytokine Levels in Subjects with Metabolic Syndrome: A Randomized, Double-Blind, Placebo- Controlled Trial

Abstract

Our findings provide a novel insight into the therapeutic effects of this therapy in MetS patients via perturbation of serum cytokines and reducing the levels of triglyceride and LDL/TC, but further studies are required in larger populations.

The effect of saffron on weight and lipid profile: A systematic review, meta‐analysis, and dose–response of randomized clinical trials

“…Pooled results from 15 studies (Abedimanesh et al, ; Azimi et al, ; Fadai et al, ; Javandoost et al, ; Kermani, Kazemi, et al, ; Kermani, Zebarjadi, et al, ; Milajerdi et al, ; Modaghegh et al, ; Mohamadpour et al, ; Nikbakht‐Jam et al, ; Sepahi et al, ) using the random‐effects model indicated that saffron as intervention resulted in nonsignificant increase in HDL levels (WMD: 0.91 mg/dl, 95% CI [−0.13, 1.96]) with significant heterogeneity among the studies ( p = .01).…”

“…and (c) studies that evaluated the effect of saffron in combination with other foods and supplements (n = 2). Fourteen articles (18 arms) representing 788 participants (Abedimanesh et al, 2017;Azimi, Ghiasvand, Feizi, Hariri, & Abbasi, 2014;Fadai et al, 2014;Gout et al, 2010;Jafarnia et al, 2017;Javandoost et al, 2017;Kermani, Kazemi, et al, 2017;Kermani, Zebarjadi, et al, 2017;Mansoori et al, 2011;Milajerdi et al, 2018;Modaghegh, Shahabian, Esmaeili, Rajbai, & Hosseinzadeh, 2008;Mohamadpour, Ayati, Parizadeh, Rajbai, & Hosseinzadeh, 2013;Nikbakht-Jam et al, 2016;Sepahi et al, 2018) met our inclusion criteria and were included in the meta-analysis.…”

“…Characteristics of eligible studies are shown in Table 1. Most studies were conducted in Iran (Abedimanesh et al, 2017;Azimi et al, 2014;Fadai et al, 2014;Jafarnia et al, 2017;Javandoost et al, 2017;Kermani, Kazemi, et al, 2017;Kermani, Zebarjadi, et al, 2017;Mansoori et al, 2011;Milajerdi et al, 2018;Modaghegh et al, 2008;Mohamadpour et al, 2013;Nikbakht-Jam et al, 2016;Sepahi et al, 2018) and one in France (Gout et al, 2010). The sample size of the included studies ranged from 20 to 81 individuals with mean age of 43 years in intervention groups and 45 years in control groups.…”

“…The results of the quality assessment of included studies are provided in Table 2. Four arms have fair quality (Modaghegh et al, 2008;Mohamadpour et al, 2013;Nikbakht-Jam et al, 2016), one has poor quality , and 13 have good quality (Abedimanesh et al, 2017;Fadai et al, 2014;Gout et al, 2010;Jafarnia et al, 2017;Javandoost et al, 2017;Kermani, Kazemi, et al, 2017;Kermani, Zebarjadi, et al, 2017;Mansoori et al, 2011;Milajerdi et al, 2018;Sepahi et al, 2018). Most studies demonstrated adequate quality for key factors.…”

“…Sixteen studies providing a total of 619 participants (intervention = 353 and control = 266) reported cholesterol as an outcome measure FIGURE 1 Forest plot of randomized controlled trials investigating the effects of saffron on [Colour figure can be viewed at wileyonlinelibrary. com] (Abedimanesh et al, 2017;Azimi et al, 2014;Fadai et al, 2014;Javandoost et al, 2017;Kermani, Kazemi, et al, 2017;Kermani, Zebarjadi, et al, 2017;Mansoori et al, 2011;Milajerdi et al, 2018;Modaghegh et al, 2008;Mohamadpour et al, 2013;Nikbakht-Jam et al, 2016;Sepahi et al, 2018). Pooled results from the randomeffects model showed that cholesterol levels reduced in the intervention group compared with the control group (WMD: −6.36 mg/ dl, 95% CI [−10.58, −2.18]).…”