Anti‐inflammatory Effect of Capsaicin in <i>Helicobacter pylori</i>‐Infected Gastric Epithelial Cells

Lee, In Ohk; Lee, Kwang Hyoung; Pyo, Jae Hee; Kim, Joo Hang; Choi, Yeun Jung; Lee, Yong Chan

doi:10.1111/j.1523-5378.2007.00521.x

Cited by 78 publications

(46 citation statements)

References 34 publications

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“…The chili pepper compound capsaicin also positively influenced the profile of the secreted cytokines and reduced iNOS expression. Our results are consistent with those in the literature, which show that capsaicin modulated NF-jB-and IL-8 pathways, and thus inhibited IL-8 production of Helicobacter pyloriinduced gastric epithelial cells (Lee et al, 2007). Capsaicin further inhibited the production of TNF-a, which might be mediated by PPARc activation (Park et al, 2004).…”

Section: Discussionsupporting

confidence: 93%

Anti-inflammatory activity of extracts from fruits, herbs and spices

2010

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Section: Discussionsupporting

confidence: 93%

Anti-inflammatory activity of extracts from fruits, herbs and spices

2010

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“…Ginger rhizome extract has been demonstrated to have defensive activity in the stomach, increase stomach mucin regeneration, reinforce antioxidant enzymes, and suppress H. pylori growth [159] . Capsaicin has an anti-inflammatory effect and inhibited H. pylori-induced interleukin (IL)-8 production by gastric epithelial cells [160] . Sulphoraphane has also been indicated to suppress colonization and inhibit gastritis in H. pylori-infected mice and humans [161] .…”

Section: Eradication: Hope Is Coming?mentioning

confidence: 99%

Antibiotic treatment forHelicobacter pylori: Is the end coming?

Kim

Choi

Chung

2015

WJGPT

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Infection with the Gram-negative pathogen Helicobacter pylori (H. pylori ) has been associated with gastroduodenal disease and the importance of H. pylori eradication is underscored by its designation as a group I carcinogen. The standard triple therapy consists of a proton pump inhibitor, amoxicillin and clarithromycin, although many other regimens are used, including quadruple, sequential and concomitant therapy regimens supplemented with metronidazole, clarithromycin and levofloxacin. Despite these efforts, current therapeutic regimens lack efficacy in eradication due to antibiotic resistance, drug compliance and antibiotic degradation by the acidic stomach environment. Core tip: This article reviews the recent literature describing antibiotic resistance and trends in Helicobacter pylori (H. pylori ) treatment. As there is no effective conventional therapy, new treatments are being developed and bismuth quadruple, sequential, concomitant therapies are recommended as a first-line regimen in regions with high levels of clarithromycin resistance. Quinolones have also been used for H. pylori treatment, although the cure rate has gradually reduced with this approach. New therapeutic directions include probiotic supplementation, tailored therapy, novel agents, and nanotechnology.

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“…The molecular mechanisms underlying capsaicin-induced apoptosis are cell-type dependent. Despite the cumulative evidence for the tumor suppressive effects of capsaicin, few studies have been undertaken concerning the effects of capsaicin on cell signaling and molecular pathways leading to apoptosis in gastric cancer (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Capsaicin induces apoptosis and modulates MAPK signaling in human gastric cancer cells

Park

Kim

Lee

et al. 2013

Molecular Medicine Reports

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Abstract. Capsaicin is known to have tumor suppressive effects. However, the molecular mechanisms and targets of capsaicin involved in exerting anticancer activity are complex and remain to be clarified. The aim of the current study was to investigate the effects of capsaicin on human gastric cancer cells (AGS cells) and demonstrate that capsaicin induced apoptosis in AGS cells. Results of the MTT assay and flow cytometry revealed that capsaicin potentially inhibited the proliferation of AGS cells and induced apoptosis in vitro in a dose-dependent manner. Cleaved caspase-3 was increased and Bcl-2 was reduced by treatment with capsaicin in AGS cells. Capsaicin treatment decreased the expression of phosphorylated ERK 1/2, p38 MAPK or JNK in AGS cells. The results of this study suggest that capsaicin may serve as an anti-tumorigenic agent in human gastric cancer.

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Anti‐inflammatory Effect of Capsaicin in Helicobacter pylori‐Infected Gastric Epithelial Cells

Cited by 78 publications

References 34 publications

Anti-inflammatory activity of extracts from fruits, herbs and spices

Anti-inflammatory activity of extracts from fruits, herbs and spices

Antibiotic treatment forHelicobacter pylori: Is the end coming?

Capsaicin induces apoptosis and modulates MAPK signaling in human gastric cancer cells

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