Anti-inflammatory effect of bee venom on antigen-induced arthritis in rabbits: Influence of endogenous glucocorticoids

Rached, Izabella Cordeiro Freire Saad; Castro, Fábio Morato; Guzzo, Maria Luiza; Mello, Suzana Beatriz Verissímo de

doi:10.1016/j.jep.2010.04.015

Cited by 19 publications

(4 citation statements)

References 24 publications

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“…Anti-inflammatory properties of HBV have been well-proven through in vivo and in vitro assays [ 10 , 16 , 26 , 56 , 57 , 58 ]. In this study, we evaluated the HBV anti-inflammatory potential of A. mellifera intermissa by assessing this substrate’s effects on the pro-inflammatory response in the RAW264.7 macrophage cell line.…”

Section: Resultsmentioning

confidence: 99%

Chemical, Cytotoxic, and Anti-Inflammatory Assessment of Honey Bee Venom from Apis mellifera intermissa

et al. 2021

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The venom from Apis mellifera intermissa, the main honey bee prevailing in Morocco, has been scarcely studied, despite its known potential for pharmacological applications. In the present work, we investigated the composition, the anti-inflammatory activity, and the venom’s cytotoxic properties from fifteen honey bee venom (HBV) samples collected in three regions: northeast, central, and southern Morocco. The chemical assessment of honey bee venom was performed using LC-DAD/ESI/MSn, NIR spectroscopy and AAS spectroscopy. The antiproliferative effect was evaluated using human tumor cell lines, including breast adenocarcinoma, non-small cell lung carcinoma, cervical carcinoma, hepatocellular carcinoma, and malignant melanoma. Likewise, we assessed the anti-inflammatory activity using the murine macrophage cell line. The study provides information on the honey bee venom subspecies’ main components, such as melittin, apamin, and phospholipase A2, with compositional variation depending on the region of collection. Contents of toxic elements such as cadmium, chromium, and plumb were detected at a concentration below 5 ppm, which can be regarded as safe for pharmaceutical use. The data presented contribute to the first study in HBV from Apis mellifera intermissa and highlight the remarkable antiproliferative and anti-inflammatory effects of HBV, suggesting it to be a candidate natural medicine to explore.

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Section: Resultsmentioning

confidence: 99%

Chemical, Cytotoxic, and Anti-Inflammatory Assessment of Honey Bee Venom from Apis mellifera intermissa

et al. 2021

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“…Previous studies have revealed that the anti-nociceptive and anti-hyperalgesic effects of DBV are strongly associated with alpha2-adrenoreceptor activation and capsaicin insensitive primary afferent fibers, but not with opioid receptors [ 9 , 11 ]. The anti-arthritic effects of DBV have been shown to involve the inactivation of nuclear factor kappa B, which inhibits the release of inflammatory cytokines [ 12 ], and an increase in endogenous glucocorticoid concentration [ 13 ]. The specificity of BV in acupoint injection is unclear, as the injection of chemical irritants other than BV into the Zusanli acupuncture point also produced significant anti-nociceptive effects [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Perineural pretreatment of bee venom attenuated the development of allodynia in the spinal nerve ligation injured neuropathic pain model; an experimental study

Koh

Choi

Lee

et al. 2014

BMC Complement Altern Med

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BackgroundDiluted bee venom (BV) is known to have anti-nociceptive and anti-inflammatory effects. We therefore assessed whether perineural bee venom pretreatment could attenuate the development of neuropathic pain in the spinal nerve ligation injured animal model.MethodsNeuropathic pain was surgically induced in 30 male Sprague Dawley rats by ligation of the L5 and L6 spinal nerves, with 10 rats each treated with saline and 0.05 and 0.1 mg BV. Behavioral testing for mechanical, cold, and thermal allodynia was conducted on postoperative days 3 to 29. Three rats in each group and 9 sham operated rats were sacrificed on day 9, and the expression of transient receptor potential vanilloid type 1 (TRPV1), ankyrin type 1 (TRPA1), and melastatin type 8 (TRPM8) receptors in the ipsilateral L5 dorsal root ganglion was analyzed.ResultsThe perineural administration of BV to the spinal nerves attenuated the development of mechanical, thermal, and cold allodynia, and the BV pretreatment reduced the expression of TRPV1, TRPA1, TRPM8 and c − Fos in the ipsilateral dorsal root ganglion.ConclusionThe current study demonstrates that the perineural pretreatment with diluted bee venom before the induction of spinal nerve ligation significantly suppresses the development of neuropathic pain. Furthermore, this bee venom induced suppression was strongly related with the involvement of transient receptor potential family members.

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“…Chen et al (2013) reported that oxyresveratrol present in mulberry leaves inhibits leukocyte migration and suppress inflammation. On the contrary it had been reported that some anti-inflammatory substances i.e., plant extracts cause the decrease in TLC (Rached et al, 2010;Al-Sadoon et al, 2012;John and Shobana, 2012).…”

Section: Hematologymentioning

confidence: 92%

Anti-Inflammatory and Analgesic Potential of Hot Water Extracts of Mulberry Leaves

Ali¹,

Tahir²,

Azizullah³

et al. 2023

JIS

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Anti-inflammatory effect of bee venom on antigen-induced arthritis in rabbits: Influence of endogenous glucocorticoids

Cited by 19 publications

References 24 publications

Chemical, Cytotoxic, and Anti-Inflammatory Assessment of Honey Bee Venom from Apis mellifera intermissa

Chemical, Cytotoxic, and Anti-Inflammatory Assessment of Honey Bee Venom from Apis mellifera intermissa

Perineural pretreatment of bee venom attenuated the development of allodynia in the spinal nerve ligation injured neuropathic pain model; an experimental study

Anti-Inflammatory and Analgesic Potential of Hot Water Extracts of Mulberry Leaves

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