Anti-inflammatory effect of atorvastatin (80 mg) in unstable angina pectoris and non–Q-wave acute myocardial infarction

Randomized Trial of Atorvastatin for Reduction of Myocardial Damage During Coronary Intervention

“…A recent study observed that even a single dose of statins may significantly improve endothelial function; 31 thus, even shortterm treatment with statin may have important effects on endothelial function and on inflammation. 32 In conclusion, the present study shows that pretreatment with atorvastatin 40 mg/d for 1 week before coronary intervention may reduce periprocedural myocardial injury in patients with stable angina. The low cost and very low risk of this therapy may support its routine use in patients undergoing percutaneous revascularization.…”

Simvastatin Prevents Vascular Hyporeactivity During Inflammation

“…An acute antiinflammatory effect of statin therapy was seen in patients with acute coronary syndromes after 5 days. 10 Short-term simvastatin therapy recently has been reported to reduce mortality in 2 different animal models of sepsis. 11,12 We have previously demonstrated that acute systemic inflammation, as induced by low doses of Escherichia coli lipopolysaccharide (LPS), results in marked endothelial dysfunction and impaired responsiveness to vasoconstrictors, 13 which is associated with oxidative stress.…”

STAR VaS - Short Term Atorvastatin Regime for Vasculopathic Subjects: a randomized placebo-controlled trial evaluating perioperative atorvastatin therapy in noncardiac surgery

“…Another difference between the DECREASE studies and our study was the choice of statin, i.e., fluvastatin vs atorvastatin. It would seem unlikely that atorvastatin would be ineffective as it has proven particularly effective for improving inflammatory levels, including CRP, 15,19 and it has been shown to be superior to other statins after acute coronary events in the nonoperative setting. 15 Atorvastatin was also used with benefit in the trial of Durazzo et al 18 While the dose of atorvastatin in STAR VaS was larger than that chosen by Durazzo, our higher dose is associated with rapid onset and benefit in nonoperative myocardial infarction studies.…”

“…15 Atorvastatin was also used with benefit in the trial of Durazzo et al 18 While the dose of atorvastatin in STAR VaS was larger than that chosen by Durazzo, our higher dose is associated with rapid onset and benefit in nonoperative myocardial infarction studies. 15,19 Feringa et al reported that higher statin doses correlated with lower perioperative and late cardiac complications in patients undergoing major vascular surgery. 20 Thus, if the findings of the DECREASE trials and the Durazzo trial are combined, the results suggest that statin therapy of 30 days or more is necessary to achieve benefit.…”

“…20,21 Acute use of statins have been shown to modify CRP levels in the nonoperative setting. 17,19 The MIRACL study showed that starting atorvastatin 80 mg 24-96 hr after an acute coronary event reduced cardiac ischemic complications and reduced CRP levels.…”