Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis

Abstract

Background Rosiglitazone and pioglitazone are high-affinity peroxisome proliferator-activated receptor (PPAR)-γ agonists with potent anti-diabetic properties and potential antiinflammatory effects. We compared the ability of a range of oral doses of these thiazolidinediones, including those sufficient to restore insulin sensitization, to inhibit the pathogenesis of adjuvant-induced arthritis (AIA).

B cell activation factor (BAFF) is a novel adipokine that links obesity and inflammation

“…We used Rosiglitazone as an anti-inflammatory drug because it is a peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist which has anti-diabetic properties and potential anti-inflammatory effects as recent studies have shown (Sańchez-Hidalgo et al, 2005;Koufany et al, 2008). Currently, Kolak and her collogues have reported that chronic Rosiglitazone therapy altered gene expression involved in fatty acid synthesis and inflammation (Kolak et al, 2007).…”

The role of resistin as a regulator of inflammation: Implications for various human pathologies

“…Statins (HMG CoA reductases) have been shown to reduce cardiovascular events and mortality. Statin treatment resulted in a significant reduction of plasma resistin in patients with type 2 diabetes and also downregulated mRNA resistin levels in PBMCs [40,136].…”

“…Moreover, it has been recently shown that higher doses of TZDs reduced bone erosions and prevented inflammatory bone loss in an experimental model of autoimmune arthritis [136].…”

PPAR-Gamma Agonist Rosiglitazone Attenuates the Inflammation Caused by Carrageenan in the Mouse Model of Pleurisy

“…Previously, it was demonstrated that rosiglitazone reduced lung inflammation in a rat model of endotoxemia induced by lipopolysaccharide [4]. Furthermore, rosiglitazone decreased neutrophil influx, pro-inflammatory cytokines, chemokines, and adhesion molecule levels in inflammation models in both rats and mice [5][6][7].…”