Anti‐Inflammatory Dose Doxycycline (40 mg Controlled‐Release) Confers Maximum Anti‐Inflammatory Efficacy in Rosacea

Theobald, K.; Bradshaw, Mark; Leyden, James J.

doi:10.1111/j.1540-9740.2007.06460.x

Cited by 19 publications

(15 citation statements)

References 12 publications

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“…Bei entsprechender Anwendung kann durch die antiinflammatorische Dosierung von Doxycyclin die Rosazea behandelt werden, ohne dabei die Effektivität und Resistenzentwicklung von Doxycylin als Antibiotikum zu beeinflussen [47,48]. Zu gleichen Ergebnissen kamen auch Theobald et al [49] sowie Wise et al [50]. Die Behandlung der okulären Rosazea gestaltet sich häufig als kompliziert.…”

Section: Systemische Therapieunclassified

Rosazea 2009

Sobottka

Lehmann

2009

Hautarzt

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Rosacea is one of the most common dermatoses of adults. In recent years many studies have contributed to a better understanding of the pathophysiology of rosacea. They suggest that an altered innate immune response is involved in the vascular and inflammatory manifestations seen in rosacea. A good understanding of the disease and its special features is necessary for the differential diagnosis of the many clinical subtypes and for a stage- and phase-specific treatment approach. Topical treatments that are widely accepted are metronidazole and azelaic acid; agents under investigation that show promise include permethrin, calcineurin inhibitors and sulfur compounds. For systemic therapy antibiotics (tetracyclines, macrolides) and recently doxycycline in anti-inflammatory rather than anti-microbial dosages are used, as well as isotretinoin in severe cases. Findings such as rhinophyma and telangiectases can be treated using different laser systems or dermabrasion. This article gives an overview regarding rosacea, a challenging condition with multiple therapeutic options.

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Section: Systemische Therapieunclassified

Rosazea 2009

Sobottka

Lehmann

2009

Hautarzt

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“…49 Doxycycline 40 mg MR provides anti-inflammatory activity at a sub-antimicrobial dose with a reduced risk of bacterial resistance compared with higher doses of doxycycline. 75,76,[79][80][81] Administration of this sub-antimicrobial dose doxycycline (40 mg) once daily for 9 months did not lead to the development of antibiotic resistance in subjects with periodontal disease. 82 The efficacy and safety of doxycycline 40 mg MR has been evaluated in multiple studies.…”

Section: Oral Therapymentioning

confidence: 99%

“…82 The efficacy and safety of doxycycline 40 mg MR has been evaluated in multiple studies. 80,81,83,84 In 2 randomized, placebo-controlled, multicentered, double-blind, 16-week trials, rosacea patients on doxycycline 40 mg MR had a significantly greater reduction in total inflammatory lesion counts than the placebo control group at week 16 when compared with baseline (P < 0.001). 49 The most common adverse reactions reported in clinical trials (incidence > 2% and more common than with placebo) are nasopharyngitis, sinusitis, diarrhea, hypertension, and aspartate aminotransferase increase.…”

Section: Oral Therapymentioning

confidence: 99%

Current Drug Therapies for Rosacea: A Chronic Vascular and Inflammatory Skin Disease

Feldman¹,

Huang²,

Huynh³

2014

JMCP

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“…The dosage of 20 mg of doxycycline hyclate twice daily or 40 mg once daily has been shown to be effective in the treatment of papulopustular rosacea with an excellent risk-benefit ratio. It has in particular been found that a 40-mg controlled-release formulation of doxycyline, applied once daily as Oracea TM , conferred peak anti-inflammatory efficacy in the treatment of rosacea [45] . At subantimicrobial doses, long-term use of anti-inflammatory-dose doxycyline might not propagate bacterial resistance [33,44,46] .…”

Section: Tetracyclines and Their Role In The Treatment Of Rosaceamentioning

confidence: 99%

Tetracycline Actions Relevant to Rosacea Treatment

Körting

Schöllmann

2009

Skin Pharmacol Physiol

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Until today, the pathogenesis of rosacea is not known in detail. Yet in recent years evidence has been accumulating that rosacea with its common symptoms such as inflammatory lesions, erythema, telangiectasia, phymatous changes, and ocular symptoms is of inflammatory nature. Tetracycline derivatives like doxycycline successfully used in the treatment of skin diseases like acne and rosacea seem to inhibit different inflammatory pathways involved in the pathogenesis by various modes of action. Although data for skin diseases are relatively scanty, the following modes of action of tetracyclines seem to be most relevant for an effective treatment of acne and rosacea: inhibition of matrix metalloproteinases, downmodulation of cytokines, inhibition of cell movement and proliferation, inhibition of granuloma formation, inhibition of reactive oxygen species, nitric oxide, and angiogenesis, whereas inhibition of phospholipase A2 seems to be of lower importance. The role of the saprophytic mite Demodex folliculorum remains to be clarified. Additional studies are necessary to further elucidate how tetracyclines work in rosacea treatment.

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Anti‐Inflammatory Dose Doxycycline (40 mg Controlled‐Release) Confers Maximum Anti‐Inflammatory Efficacy in Rosacea

Abstract: Higher mg/kg doses led to higher plasma concentrations but did not lead to increased clinical efficacy. Anti-inflammatory dose doxycycline (40-mg controlled-release formulation) conferred peak anti-inflammatory efficacy in the treatment of rosacea.

Cited by 19 publications

References 12 publications

Rosazea 2009

Rosazea 2009

Current Drug Therapies for Rosacea: A Chronic Vascular and Inflammatory Skin Disease

Tetracycline Actions Relevant to Rosacea Treatment

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