Anti-Inflammatory Compounds from Sideritis javalambrensis N-Hexane Extract

Abstract

The anti-inflammatory activities of the n-hexane extract of Sideritis javalambrensis and several purified fractions were investigated using the carrageenan mouse paw edema test. Progressive fractionation led to the isolation of the active principles ent-16-hydroxy-13-epimanoyl oxide [1] and esters of tyrosol with palmitic, stearic, behenic, and lignoceric acids.

Analgesic and antiinflammatory properties of Sideritis lotsyi var. Mascaensis

“…Comparable results were found with other studies of the genus Sideritis (Alcaraz et al, 1989;Pang et al, 1996;Navarro et al, 1997).…”

“…The genus Sideritis (Lamiaceae) is widely distributed in Eastern Spain and is well known as a source of antiinflammatory agents (Alcaraz et al, 1989;Pang et al, 1996;Navarro et al, 1997). In the Canaries this genus is represented by 19 endemic species and various researchers have reported different constituents, however, very few of its pharmacological effects have been reported (Darias et al, 1990).…”

Study of the antioedema activity of some seaweed and sponge extracts from the mediterranean coast in mice

“…Carrageenan rat paw oedema (Winter et al, 1962) is a suitable test for evaluating antiinflammatory drugs which has been frequently used to assess the antioedematous effect of natural products (Della Loggia et al, 1986; Alcaraz and Ferrandiz, 1987;Villar et al, 1987;Alcaraz and Jimenez, 1988;Alcaraz et al, 1989;Ferrandiz and Alcaraz, 1991). This model shows proportionality between laboratory test dose and clinical dose (Otterness and Gans, 1988) and has been adapted for utilization in mice (Sugishita et al, 1981).…”

Antinociceptive and Antiinflammatory Activities of Anastatica hierochuntica and Possible Mechanism of Action

“…Carrageenan-induced rat paw oedema test was performed as described by Alcaraz et al [24] with minor modifications. Groups of five animals each were used.…”