Anti-Inflammatory Approach in Chronic Dialysis Patients with SARS-CoV-2: ATA or PMMA Dialyzers?

Abstract

<b><i>Introduction:</i></b> High-flux hemodialysis membranes may modulate the cytokine storm of SARS-CoV-2, but their impact on chronic hemodialysis (CHD) patients is unknown. The aim of the study was the evaluation of asymmetric cellulose triacetate (ATA) and polymethylmethacrylate (PMMA) dialyzers on inflammatory markers and clinical outcomes in CHD patients with SARS-CoV-2. <b><i>Methods:</i></b> A prospective, observational study on CHD patients with SARS-CoV-2 was carried out. Patients were enrolled from March 2020 to May 2021. Pre- and postdialysis C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) were determined at each session. Patients who underwent on-line hemodiafiltration (OLHDF) with a PMMA dialyzer were compared with those treated with OLHDF with a ATA dialyzer. The primary endpoint was the differences in the reduction ratio per session (RR) of CRP, PCT, IL-6, and IL-6 RR >25%. <b><i>Results:</i></b> We consecutively enrolled 74 CHD patients with COVID-19, 48 were treated with ATA membrane, and 26 with PMMA. Median IL-6 RR was higher in the ATA group compared to PMMA (17.08%, IQR −9.0 to 40.0 vs. 2.95%, IQR −34.63 to 27.32). Median CRP RR was 7.77% (IQR 2.47–13.77) in the ATA group versus 4.8% (IQR −2.65 to 11.38) in the PMMA group (<i>p</i> = 0.0017). Median PCT-RR% was 77.38% (IQR 70.92–82.97) in ATA group versus 54.59% (IQR 42.62–63.16) in the PMMA group (<i>p</i> < 0.0001). A multiple logistic regression analysis with IL-6 RR >25% as the outcome including the membrane employed, pre-dialysis IL-6, CRP, PCT, and ferritin showed that ATA led to a higher probability to reach the outcome (OR 1.891, 95% CI 1.273–2.840, <i>p</i> = 0.0018) while higher CRP favors the risk of lower IL-6 RR values (OR 0.910, 95% CI 0.868–0.949, <i>p</i> ≤ 0.0001). <b><i>Conclusions:</i></b> In SARS-CoV-2 CHD patients treated with OLHDF, ATA showed a better anti-inflammatory profile, regarding IL-6 RR, compared to PMMA.

Albumin redox state of maintenance haemodialysis patients is positively altered after treatment

“…There was a tendency for lower HNA-1/HNA-2 fractions after haemodialysis treatment with a PMMA or CTA dialyzer compared to polysulfone dialyzers. These results are limited by the low number of patients in these subgroups, but in line with the findings of a larger prospective observational trial by Donati et al [ 25 ]. Further, the PMMA and CTA based dialyzers do not contain PVP.…”

Immune responses of patients on maintenance hemodialysis after infection by SARS-CoV-2: a prospective observational cohort study

“…The use of filters by asymmetric cellulose triacetate (ATA) was compared to filters by polymethylmethacrylate (PMMA). Using a multivariate logistic regression model, the authors concluded that ATA favoured the retention of IL-6 [ 20 ]. In the second small-scale randomized trial, 15 patients underwent HD using medium cut-off (MCO) membranes and were compared to 14 patients who underwent HD using filters by PMMA.…”

Malnutrition and Erythropoietin Resistance among Patients with End-Stage Kidney Disease: Where Is the Perpetrator of Disaster?

“…Other group of research on reducing IL-6 levels in hemodialyzed is based on choosing adequate dialysis technique. Donati et al found that asymmetric cellulose acetate (ATA) dialyzers were superior when it comes to removing IL-6 over polymethylmethacrylate (PMMA) dialyzers [33]. A randomized controlled trial by Weiner et al aimed to examine the efficacy of medium cut-off dialyzers vs. standard high-flux dialyzers in removal of uremic toxins during four-and 24-week period.…”