Anti-inflammatory, antiviral and quantitative study of quercetin-3-O-β-D-glucuronide in Polygonum perfoliatum L.

Fan, Dongsheng; Zhou, Xin; Zhao, Chunjiang; Chen, Huaguo; Zhao, Yang; Gong, Xiaoyi

doi:10.1016/j.fitote.2011.04.007

Cited by 96 publications

(75 citation statements)

References 12 publications

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“…As one of the most abundant and active ingredient from P. perfoliatum l., we tested the potential therapeutic effect of flavonoid in treating HSV-1 infection in vitro and in vivo. Previously, experimental and clinical data have demonstrated the P. perfoliatum l. and its methanol extract can be used to treat various inflammatory diseases such as rheumatoid arthritis, indicative of anti-inflammatory effect of P. perfoliatum l. (Cheng et al, 2012;Fan et al, 2011). Several other studies also indicated the antioxidant and antiviral effects of flavonoid from medicinal herbs (Nijveldt et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

The flavonoid from Polygonum perfoliatum L. inhibits herpes simplex virus 1 infection

Zhang¹,

Wei²,

Liu³

et al. 2014

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Summary. -Herpes simplex virus 1 (HSV-1) is one of the most prevalent human pathogens in both industrialized and developing countries. This study was performed to analyze the antiviral activity of purified flavonoid from Polygonum perfoliatum l. against HSV-1 infection in vitro and in vivo. Flavonoid showed no inhibitory effect, when treated before virus infection, but it strongly inhibited viral replication and cell-to-cell spread which was vital for the virus's propagation. The therapeutic effect of the flavonoid in treating HSV-1 induced encephalitis was also investigated in mice. A dose-dependent increase of survival rate and mean survival time (MST) were observed in the flavonoid-treated mice. These results suggested that the flavonoid may be a viable therapeutic option for recurrent HSV-1 infection.Keywords: herpes simplex virus 1; flavonoid; Polygonum perfoliatum l.; antiviral, Hep-2 cell; mouse Acta virologica 58: 368 -373, 2014 doi:10.4149/av_2014_04_368 * Corresponding author. E-mail: zqyang@whu.edu.cn; phone: +862768759136. Abbreviations: ACV = acyclovir; EC 50 = 50% effective concentration; HSV-1= herpes simplex virus 1; IFA = immunofluorescence assay; MST = mean survival time; p.i. = post infection; SI = selectivity index; TC 50 = 50% toxic concentration

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Section: Discussionmentioning

confidence: 99%

The flavonoid from Polygonum perfoliatum L. inhibits herpes simplex virus 1 infection

Zhang¹,

Wei²,

Liu³

et al. 2014

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“…Since miquelianin possessing the structure of quercetin 3-O-glucuronide has been reported to have anti-depressant activity [21], anti-stress activity [22], cytotoxic and anti-oxidant activity [23], anti-psoriatic activity [24], anti-inflammatory and anti-viral activity [25]. Another isolated compound, kaempferol 3-O-glucuronide also possessed cytotoxic and anti-oxidant activity [23].…”

Section: Discusssionmentioning

confidence: 99%

Activity guided isolation of chemical constituents from the biologically active methanol extract of Euphorbia schimperi C. Presl

Ahmed¹,

e-Alam²,

Mothana³

et al. 2018

Bull. Chem. Soc. Eth.

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ABSTRACT. In this study we investigated the chemical constituents of bioactive methanol extract of Euphorbia schimperi C. Presl. For this the methanol extract was fractionated into 20, 40, 60, 80% MeOH in CHCl3, and 100% MeOH fractions respectively by vacuum liquid chromatography. Excision wound surface of the animals were topically treated with these fractions at a dose of 100 mg/kg body weight for twenty days. Povidone-iodine ointment was used as a reference drug. Wound contraction measurement and period of epithelialization were used to assess the effect of fractions on wound repairing. The 100% MeOH fraction treated animals achieved significant (p < 0.001) value by showing 100% wound contraction and minimum period of epithelization (17.75±0.47) on the 20 th day as compared to standard drug treated animals on the same day. The active 100% MeOH fraction was subjected to various chromatographic techniques led to the isolation of miquelianin (1), kaempferol 3-O-glucuronide (2) and quercitrin (3). Compounds (1-3) were isolated from this plant for the first time.

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“…Antioxidant activity [4], [5], [6], [7], [8] [16], [17], [18], [19], [20], [21], [22] Anticancer activity [2], [23], [24], [25], [26] Cardiovascular protection [4], [27], [28], [29], [30] Antimicrobial activity [31], [32], [33] Anti-inflammatory activity [34], [35], [36], [37], [38], [39] Hepatoprotective activity [40], [41], [42] …”

Section: Pharmacological Property Referencesmentioning

confidence: 99%

“…Furthermore, quercetin has been reported to suppress the hepatitis C virus by inhibiting nonstructural protein 3 protease activity [20]. Quercetin-3-O-β-D-glucuronide, during in vivo studies has been reported to be effective against influenza-A virus [21] and quercetin 7-rhamnoside was found effective against porcine epidemic diarrhea virus [22].…”

Section: Antiviral Activitymentioning

confidence: 99%

Pharmacological Applications of Quercetin and its Derivatives: A Short Review

Maalik¹,

Fa²,

Mumtaz³

et al. 2014

Trop. J. Pharm Res

116

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Quercetin (3,3ʹ,4ʹ,5,7-pentahydroxyl- flavone) is a flavonol, and it belongs to a class of plant secondary metabolites known as flavonoids. It is present in man's daily diet and is known for biological activities such as antioxidant, antiviral, anticancer, antimicrobial, anti-inflammatory and many more. Quercetin has been reported for its antioxidant and antiviral applications, hence, it is not only used as such but also its various derivatized forms have potentials for development into drugs for the treatment of diseases caused by oxidative stress and lethal viruses.

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Anti-inflammatory, antiviral and quantitative study of quercetin-3-O-β-D-glucuronide in Polygonum perfoliatum L.

Cited by 96 publications

References 12 publications

The flavonoid from Polygonum perfoliatum L. inhibits herpes simplex virus 1 infection

The flavonoid from Polygonum perfoliatum L. inhibits herpes simplex virus 1 infection

Activity guided isolation of chemical constituents from the biologically active methanol extract of Euphorbia schimperi C. Presl

Pharmacological Applications of Quercetin and its Derivatives: A Short Review

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