Anti-inflammatory, Antioxidant, Lung and Liver Protective Activity of
Galaxaura oblongata as Antagonistic Efficacy against LPS using Hematological
Parameters and Immunohistochemistry as Biomarkers

Nabil-Adam, Asmaa; Shreadah, Mohamed A.

doi:10.2174/1871525719666210112154800

Cited by 3 publications

(2 citation statements)

References 79 publications

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“…Activation of NF-κB in the liver results in elevated levels of TNF-α, IL-1, and IL-6 expression. Marine organisms are a wealthy supply of anti-inflammatory, biologically bioactive lipids. − , The current study confirmed the ability of GOE as a potent antioxidant and anti-inflammatory agent. It examined the bioactive secondary metabolite contents of polyphenolic compounds and fatty acids through an investigation for anti-inflammatory by inhibiting the manufacturing of NO, ACHI, (TNF-α) in LPS-induced lung mouse tissues .…”

Section: Discussionsupporting

confidence: 71%

“…The Red Sea marine environment is a unique and rich natural resource for many bioactive substances with unique structural features due to its phenomenal biodiversity. Marine bioactive compounds, including marine plants, macro- and microalgae, microorganisms, and sponges, can be derived from various sources containing their own unique set of biomolecules. − Macroalgae, or seaweed, are found in tropical waters and intertidal regions. They are rich in interesting bioactive components, including vitamins, hormones, carotenoids, etc., showing potential positive uses in healthcare. − The study aims to investigate the protective effect of Galaxaura oblongata (G.…”

Section: Introductionmentioning

confidence: 99%

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Modulation of MAPK/NF-κB Pathway and NLRP3 Inflammasome by Secondary Metabolites from Red Algae: A Mechanistic Study

Nabil-Adam,

Ashour,

Shreadah

2023

ACS Omega

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The pharmacological properties of seaweeds are diverse. No studies have been conducted on the protective effect of Galaxaura oblongata (GOE) against lippopolysaccharide (LPS)-induced inflammation in the brain. This study is divided into three phases, the first of which is the initial phase. In vitro study includes antioxidant, radical scavenging, and anti-inflammatory activities, including cyclooxygenase-1 (COX1), COX2, NO, acetylcholine inhibition, sphingosine kinase 1, tumor necrosis factor α (TNF-α), and interleukin-6, as well as antioxidant and radical-scavenging activities, including 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azinobis(3-ethylbenzothiazoline)-6-sulfonic acid. Using LPS-induced acute inflammation, the second phase was conducted in vivo. Antioxidant and anti-inflammatory assays were performed to investigate the protective role of GOE. In addition to the phytochemical analysis, the bioactive content of GOE was also investigated. In vitro results demonstrated the potential of GOE as an antioxidant, anti-inflammatory, and neuroprotective agent. A study using LPS as an induced lung injury and neuroinflammation model confirmed the in vitro results. The GOE significantly reduced inflammatory, oxidative, and neurodegenerative biomarkers based on histopathological and immuno-histochemistry results. Based on computational drug design, four target proteins were approved: nuclear factor κB, mitogen-activated protein kinases, TNF-α, and NLRP3. Using polyphenolic compounds in GOE as ligands demonstrated good alignment and affinity against the three proteins. Finally, the current study offers a new approach to developing drug leads considering GOE's protective and curative roles.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Modulation of MAPK/NF-κB Pathway and NLRP3 Inflammasome by Secondary Metabolites from Red Algae: A Mechanistic Study

Nabil-Adam,

Ashour,

Shreadah

2023

ACS Omega

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The hepatoprotective candidates by synergistic formula of marine and terrestrial against Acetaminophen toxicity using in-vitro, in-vivo, and in silico screening approach

Nabil-Adam

Ashour

Shreadah

2023

Saudi Journal of Biological Sciences

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Flavonoids Biosynthesis in Plants as a Defense Mechanism: Role and Function Concerning Pharmacodynamics and Pharmacokinetic Properties

Nabil-Adam¹,

Elnosary²,

Ashour³

et al. 2023

Flavonoid Metabolism - Recent Advances and Applications in Crop Breeding

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Flavonoids are a major class of secondary metabolites that comprises more than 6000 compounds that have been identified. They are biosynthesized via the phenylpropanoid metabolic pathway that involves groups of enzymes such as isomerases, hydroxylases, and reductases that greatly affect the determination of the flavonoid skeleton. For example, transferase enzymes responsible for the modification of sugar result in changes in the physiological activity of the flavonoids and changes in their physical properties, such as solubility, reactivity, and interaction with cellular target molecules, which affect their pharmacodynamics and pharmacokinetic properties. In addition, flavonoids have diverse biological activities such as antioxidants, anticancer, and antiviral in managing Alzheimer’s disease. However, most marine flavonoids are still incompletely discovered because marine flavonoid biosynthesis is produced and possesses unique substitutions that are not commonly found in terrestrial bioactive compounds. The current chapter will illustrate the importance of flavonoids’ role in metabolism and the main difference between marine and terrestrial flavonoids.

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Anti-inflammatory, Antioxidant, Lung and Liver Protective Activity of Galaxaura oblongata as Antagonistic Efficacy against LPS using Hematological Parameters and Immunohistochemistry as Biomarkers

Cited by 3 publications

References 79 publications

Modulation of MAPK/NF-κB Pathway and NLRP3 Inflammasome by Secondary Metabolites from Red Algae: A Mechanistic Study

Modulation of MAPK/NF-κB Pathway and NLRP3 Inflammasome by Secondary Metabolites from Red Algae: A Mechanistic Study

The hepatoprotective candidates by synergistic formula of marine and terrestrial against Acetaminophen toxicity using in-vitro, in-vivo, and in silico screening approach

Flavonoids Biosynthesis in Plants as a Defense Mechanism: Role and Function Concerning Pharmacodynamics and Pharmacokinetic Properties

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