Anti-Inflammatory, Antioxidant, and Skin Regenerative Potential of Secondary Metabolites from Plants of the Brassicaceae Family: A Systematic Review of In Vitro and In Vivo Preclinical Evidence (Biological Activities Brassicaceae Skin Diseases)

Abstract

The Brassicaceae family constitutes some of the most well-studied natural products in the world, due to their anti-inflammatory, anti-oxidative, and pro-regenerative properties as well as their ubiquitous distribution across the world. To evaluate the potential efficacy of the Brassicaceae family in the treatment of inflammatory skin disorders and wounds, based on preclinical evidence from in vivo and in vitro studies. This systematic review was performed according to the PRISMA guidelines, using a structured search on the PubMed-Medline, Scopus, and Web of Science platforms. The studies included were those that used murine models and in vitro studies to investigate the effect of Brassicaceae on skin disorders. Bias analysis and methodological quality assessments were examined through SYRCLE’s RoB tool. Brassicaceae have shown positive impacts on inflammatory regulation of the skin, accelerating the wound healing process, and inhibiting the development of edema. The studies showed that the Brassicaceae family has antioxidant activity and effects on the modulation of cyclooxygenase 2 and the nuclear factor kappa β (NFκβ) pathway. The secondary metabolites present in Brassicas are polyphenols (68.75%; n = 11), terpenes/carotenoids (31.25%; n = 5), and glycosylates (25%; n = 4), which are responsible for their anti-inflammatory, healing, and antioxidant effects. In addition, the current evidence is reliable because the bias analysis showed a low risk of bias. Our review indicates that compounds derived from Brassicaceae present exceptional potential to treat inflammatory skin diseases and accelerate cutaneous wound healing. We hope that our critical analysis can help to expedite clinical research and to reduce methodological bias, thereby improving the quality of evidence in future research. The registration number on the Prospero platform is CRD42021262953.

Biological Investigation and Chemical Study of Brassica villosa subsp. drepanensis (Brassicaeae) Leaves

“…A review has recently reported that, upon fractionation, plant extracts frequently lose their biological activities, suggesting that the exerted effects result from the whole phytocomplex, acting synergistically or additively, rather than a single fraction or compound [ 42 ]. Several studies reported that secondary metabolites from the Brassicaceae family, including kaempferol, possess valuable in vitro and in vivo anti-inflammatory and antioxidant activities [ 30 ], in agreement with our findings confirming the high potential of B. drepanensis extract in counteracting the early stages of oxidative stress and inflammation, which are transversals in many pathological conditions, including obesity and its associated complications, such as type 2 diabetes [ 29 , 43 ]. The effects of natural compounds on metabolic disorders differ, and include amelioration in energy expenditure, insulin secretion, glucose utilization, satiety, or beneficial interference with the gut microbiome [ 44 ].…”

“…Many in vitro and in vivo studies support the anti-inflammatory effect of phytochemicals from different Brassica spp. and their cultivated varieties [ 30 ]. B. drepanensis is a wild relative of cultivated cabbages.…”

The Phytochemical Screening and Biological Properties of Brassica napus L. var. napobrassica (Rutabaga) Seeds

“…Brassica species harbor an impressive repertoire of nutrients such as minerals, essential vitamins, carbohydrates, and phytochemicals, including phenolic compounds, glucosinolates and their breakdown products (isothiocyanates and indoles), carotenoids, and seed oils, recognized as bioactive secondary metabolites [5]. The metabolites synthesized by each species are responsible for providing a unique and distinct taste as well as exhibiting broadly interesting and beneficial bioactivities such as antioxidant [3], anti-inflammatory [6], antimicrobial [7], and anticancer bioactivities [8].…”

Electrospun nanofibers synthesized from polymers incorporated with bioactive compounds for wound healing

“…These models will enable us to measure and monitor different stages of wound healing, especially the inflammatory and proliferative phases. Some studies tend to use male animals more frequently due to the impact of hormonal cycles in females and their heightened sensitivity to toxicity [ 237 ]. The in vivo evaluation of dual-growth factor-releasing meshes on rat skin wounds yielded promising results [ 238 ].…”