Anti-inflammatory, antioxidant, and gaso-protective mechanism of 3α-hydroxymasticadienoic acid and diligustilide combination on indomethacin gastric damage

Pineda-Peña, Elizabeth Arlen; Orona-Ortiz, Alejandra; Velázquez-Moyado, Josué Arturo; Carvalho, José Carlos Tavares; Chávez-Piña, Aracely Evangelina; Balderas-López, José Luis; Castro, Andrés Navarrete

doi:10.1007/s00210-020-01857-7

Cited by 8 publications

(6 citation statements)

References 61 publications

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“…Inflammation and oxidative stress are closely related in some pathologic processes, and they both exist at the same time under many pathologic conditions (Fagundes et al, 2021). A continuous inflammation can aggravate the gastric mucosa injury; thus, controlling the content of proinflammatory factors can effectively inhibit and prevent some gastric lesions (Pineda-Peña et al, 2020). NF-kB, a key transcription factor linking oxidative stress and inflammatory response, normally exists in the cytoplasm in an inactive form (Ko et al, 2020) and can induce the expression of a variety of pro-inflammatory factors.…”

Section: Downloaded Frommentioning

confidence: 99%

Protective Effect of Anwulignan on Gastric Injury Induced by Indomethacin in Mice

Liu

Fang

Zhang

et al. 2022

J Pharmacol Exp Ther

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Anwulignan (AN) is a monomer lignan from Schisandra sphenanthera Rehd. et Wits (Schisandra sphenanthera fructus, Schisandra sphenanthera). The protective effect of AN against the indomethacin (IND)-induced gastric injury to mice and the related mechanism of action was investigated in this study. The effect of AN was mainly assessed by observing the gastric tissue morphology, gastric ulcer index (GUI), ulcer inhibition rate (UIR), gastric juice volume (GJV) and pH value. Chemical colorimetry, immunofluorescence, ELISA, and Western blot were used to detect related factors in the gastric tissue. The results showed that AN reduced the GUI, increased the UIR, inhibited the GJV, and increased the gastric pH value. AN significantly increased cyclooxygenase-1, cyclooxygenase-2, and prostaglandin E2 expression levels in the gastric tissue, activated nuclear factor (erythroid-derived 2)-like 2 (Nrf2), increased heme oxygenase-1 expression, enhanced the activity of superoxide dismutase and glutathione peroxidase, and decreased the malondialdehyde content. AN reduced the phosphorylation of nuclear factor-k gene binding (NF-kB) p65 and its nuclear translocation, the key protein of NF-kB signaling pathway in the gastric tissue, and the content of the pathway downstream signaling molecules, including interleukin-6, interleukin-1b, and tumor necrosis factor-a, to play an anti-inflammatory role. AN inhibited the downstream signals B-cell lymphoma 2associated x protein and cleaved caspase-3 in gastric tissue, and activated B-cell lymphoma 2, to play an antiapoptotic role, which were further verified by Hoechst staining. Therefore, AN has a significant protection against the gastric injury induced by IND in mice, and the mechanism may be concerned in its activation of Nrf2, inhibition of NF-kB signaling pathway, and antiapoptotic effect. SIGNIFICANCE STATEMENTAnwulignan (AN) significantly reduced the indomethacininduced gastric injury in mice, and its antioxidation, antiinflammation, and antiapoptosis were considered to be involve in the effect, suggesting that AN should be a potential drug or food supplement for gastric injury induced by indomethacin.

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Section: Downloaded Frommentioning

confidence: 99%

Protective Effect of Anwulignan on Gastric Injury Induced by Indomethacin in Mice

Liu

Fang

Zhang

et al. 2022

J Pharmacol Exp Ther

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Section: Antiulcer and Gastroprotectivementioning

confidence: 99%

“…Coult & Rose), administered orally in a model of gastric injury induced by indomethacin, was reported. It is suggested that the gastroprotective mechanism of action involves increased prostaglandin synthesis and reduced leukocyte infiltrate, TNF-α, and leukotriene B4 [61]. [7,48], gastroprotective [57][58][59][60][61], antimicrobial [5,9,46,47,62,63], anti-virulence [64,65], wound healing [10], and hypocholesterolemic activity [44].…”

Section: Anti-inflammatorymentioning

confidence: 99%

“…Furthermore, the anti-inflammatory effect of the ethanolic extract has been demonstrated in a model of colitis induced by dextran sulfate sodium in mice. Oral administration of the extract at 200 mg/kg for ten days reduced colonic inflammation and increased [7,48], gastroprotective [57][58][59][60][61], antimicrobial [5,9,46,47,62,63], anti-virulence [64,65], wound healing [10], and hypocholesterolemic activity [44].…”

Section: Anti-inflammatorymentioning

confidence: 99%

“…Pharmacological properties of A. adstringens stem bark extracts and main bioactive metabolites. Anticancer [5-7,42,43,45,49-55], anti-inflammatory[7,48], gastroprotective[57][58][59][60][61], antimicrobial[5,9,46,47,62,63], anti-virulence[64,65], wound healing[10], and hypocholesterolemic activity[44].…”

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confidence: 99%

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Amphipterygium adstringens (Schltdl.) Schiede ex Standl (Anacardiaceae): An Endemic Plant with Relevant Pharmacological Properties

Sotelo-Barrera

Cília-García

Luna‐Cavazos

et al. 2022

Plants

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Diseases, such as cancer, peptic ulcers, and diabetes, as well as those caused by drug-resistant infectious agents are examples of some of the world’s major public health problems. Amphipterygium adstringens (Schltdl.) Schiede ex Standl is an endemic tree to Mexico. Its stem bark has been used medicinally since pre-Hispanic times, but in recent decades it has been scientifically proven that it has properties that help counteract some diseases; extracts with organic solvents of the plant are outstanding for their anticancer, gastroprotective, and antimicrobial properties; terpenes and long-chain phenols have been identified as the main active compounds. Currently, overharvesting is causing a sharp reduction in natural populations due to an increase in demand for the stem bark by people seeking to improve their health and by national and transnational companies seeking to market it. Because of the growing interest of the world population and the scientific community, we reviewed recent studies on the bioactive properties of A. adstringens. Through the orderly and critical compendium of the current knowledge of A. adstringens, we provide a reference for future studies aimed at the rational use and protection of this valuable endemic natural resource.

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Anti-inflammatory potential of baicalein combined with silk fibroin protein in a zebrafish model (Danio rerio)

et al. 2022

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Baicalein (BA) is a flavonoid with wideranging pharmacological activity. However, its biological evaluation is hampered by its low solubility in aqueous medium, making forms of incorporation that improve its solubility necessary. In the present study, BA was combined with a solution of silk fibroin protein (SF), a biomaterial used too as a drug carrier, to evaluate the anti-inflammatory potential of this combination, in vivo, in an experimental model, zebrafish (Danio rerio). Baicalein-silk fibroin (BASF) improved the DPPH (2,2-diphenyl-1-picrylhydrazyl-hydrate) free radical scavenging rate (95%) in comparison with BA in solution. The acute toxicity study and histopathological analysis in zebrafish showed that BASF has low cytotoxic potential, except for the maxim dose of 2000 mg/kg. The use of BA in combination with SF enhanced the anti-inflammatory effect of flavonoids by inducing inflammatory peritoneal edema through carrageenan and achieved 77.6% inhibition of abdominal edema at a dose of 75 mg/kg. The results showed that the BASF, significantly increases the bioavailability and therapeutic effect of flavonoids and several results observed in this study may help in the development of new drugs.

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Anti-inflammatory, antioxidant, and gaso-protective mechanism of 3α-hydroxymasticadienoic acid and diligustilide combination on indomethacin gastric damage

Cited by 8 publications

References 61 publications

Protective Effect of Anwulignan on Gastric Injury Induced by Indomethacin in Mice

Protective Effect of Anwulignan on Gastric Injury Induced by Indomethacin in Mice

Amphipterygium adstringens (Schltdl.) Schiede ex Standl (Anacardiaceae): An Endemic Plant with Relevant Pharmacological Properties

Anti-inflammatory potential of baicalein combined with silk fibroin protein in a zebrafish model (Danio rerio)

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