Anti-inflammatory, Antinociceptive, and Antioxidant Potentials of Algerian Zizyphus jujuba Mill. Fruits and Leaves In Vivo and In Vitro in Different Experimental Models

Abstract

The ethanolic extracts of the aerial parts, leaves, and fruits, of Zizyphus jujuba Mill. were studied in vivo and in vitro for their anti-inflammatory, analgesic, and antioxidant properties, respectively. A preliminary phytochemical screening was carried out. It revealed the presence of several phytoconstituents such as flavonoids, phenols, and alkaloids. The acute toxicity study was conducted using a limit dose of 2,000mg/kg. The extracts studied showed no signs of toxicity or mortality. Anti-inflammatory activity, assessed by carrageenan-induced paw edema, and antinociceptive activity, assessed by pain-induced acetic acid in mice, were significantly reduced (P < 0.001). Moreover, both extracts showed considerable DPPH scavenging activity and β-carotene protective capacity. The present study suggests that leaf and fruit extracts from Zizyphus jujuba have a pharmacological interest probably related to the presence of some bioactive compounds and could be a potential source of antiinflammatory, antinociceptive, and antioxidant agents that should be further investigated.

Can tree leaves be used as an alternative source of synthetic antioxidants? Use of jujube leaf extract in laying hens

“…Özgan ( 41 ) in a study investigating the possibilities of using grape seed oil in laying hens, reported that they thought that β-ovomucin in the structure of albumen was protected thanks to the antioxidant properties of this oil and accordingly, albumen height could increase. Many studies ( 13 , 14 , 42 , 43 ) have reported that jujube leaf extract has antioxidant properties. Based on this information, it can be said that JLE increased the albumen index and Haugh unit in the present study due to its antioxidant properties.…”

“…Jujube is a medicinal plant in the Rhamnaceae family ( 12 ). Studies ( 13 , 14 ) have shown that the leaves of this plant are important as antioxidants. There are a limited number of studies on the use of Zizyphus jujuba leaves in animal nutrition.…”