Anti-inflammatory, anti-oxidant effect and cytotoxicity of Ocimum sanctum intra oral gel for combating periodontal diseases

Ramamurthy, Jaiganesh

doi:10.6026/973206300161026

Cited by 8 publications

(8 citation statements)

References 10 publications

(10 reference statements)

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“…It is less toxic than brine shrimp nauplii. Ocimum Sanctum (Tulsi) proved to be the most favourable agent for the therapy of periodontal conditions [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

Comparative clinical data for gingivitis treatment using gels from Ocimum sanctum (Tulsi) and chlorhexidine (CHX)

Deepika¹

2021

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Ocimum sanctum (Tulsi) has various properties like anti bacterial, anti inflammatory, anti oxidant for curing diseases. It is a plant with known medicinal value in Indian system of medicine. Therefore, it is of interest to evaluate the effectiveness of Ocimum sanctum with Chlorhexidine (CHX) which is a standard material for the treatment of gingivitis. We used 30 gingivitis subjects divided into 2 groups. Group I used Tulsi gel (n= 15) and Group II used CHX gel (n = 15) for treatment. Tulsi and CHX gel use was advised for 1 month. The Clinical parameters assessed were gingival Index (GI), plaque Index (PI), probing depth (PD) and clinical attachment loss (CAL) assessed at a time interval of 30 days. Statistical analysis was completed using the SPSS software 23.0. Data showed that GI and PD for Tulsi and CHX in pre and post groups are not significant with p > 0.05. Moreover, PI is not significant with p>0.05 among pre Tulsi, pre CHX and post CHX. However, data is significant with p<0.05 for Tulsi group. CAL is significant with p<0.05 among pre/post Tulsi groups. However, this is not significant with p>0.05 among pre/post CHX groups. Data shows that 2% of Tulsi is effective in reducing gingival bleeding and inflammation. Thus, clinical data shows that Tulsi gel is promising for the treatment of gingivitis.

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“…It is less toxic than brine shrimp nauplii. Ocimum Sanctum (Tulsi) proved to be the most favourable agent for the therapy of periodontal conditions [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

Comparative clinical data for gingivitis treatment using gels from Ocimum sanctum (Tulsi) and chlorhexidine (CHX)

Deepika¹

2021

Bioinformation

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“…The hydroxyl groups in flavonoids alters their properties by chelating metal ions and breaking the antioxidant chain (19). Ascorbic acid, glutathione, and unsaturated fatty acids further enhance the antioxidant activity, making it a potent free radical scavenger (20). This activity is substantially amplified by the increased superoxide dismutase enzyme activity.…”

Section: Discussionmentioning

confidence: 99%

Exploring Synergies of Lotus Seed Extract-Hyaluronic Acid Gel for Enhanced Local Drug Delivery

Suresh,

Gurumurthy,

2024

BSCM

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OBJECTIVE The plant species Nelumbo nucifera (lotus) is widely used in traditional medicine and is known to contain flavonoids, alkaloids, and other polyphenols which contribute to its potent antioxidant, anti-inflammatory properties in addition to its being a remedy for cardiac diseases. Hyaluronic acid, present in skin and connective tissue, is well known for its tissue regeneration and wound healing properties. The present study aimed to determine the antioxidant and anti-inflammatory effect of the hyaluronic acid gel combined with lotus seed extract and how this combination could be used as an effective local drug delivery system for the treatment of periodontitis. METHODS A 2% solution of hyaluronic acid gel was combined with increasing concentrations of prepared lotus seed extract. A DPPH test was conducted to determine the antioxidant activity of the resultant mixture at increasing concentrations. Additionally, anti-inflammatory activity was assessed using a UV spectrometer, and the spreadability of the gel was measured using the sliding glass slide method. The values obtained were plotted on graphs.. RESULTS The DPPH scavenging assay revealed that lotus seed extract with 2% hyaluronic acid gel exhibited increased antioxidant activity in a dose-dependent manner with IC50 at 76 μL. The lotus seed extract with 2% hyaluronic acid gel also showed increased anti-inflammatory properties in a dose-dependent manner with IC50 at 271 μL. Moreover, the spreadability of the lotus seed extract with 2% hyaluronic acid gel was found to be 42 mm. CONCLUSIONS Lotus seed extract shows potent antioxidant and anti- inflammatory activities which vary with the concentration of the extract, and can serve as an effective local drug delivery system.

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“…Tulsi neutralizes the free radicals produced by various oral lesions through the presence of antioxidants like vitamins A, E, and C [11]. The antioxidant effect of tulsi is due to the presence of phenolic components like cirsilineol, circimaritin, rosameric acid, and apigenin, which are yielded from the extract of tulsi [12].…”

Section: Antioxidant Effect :-mentioning

confidence: 99%

“…Tulsi strengthens the human body`s immune system by increasing interferon, interleukin-4, and T-helper cells by acting as an immunomodulator [12,13].…”

Section: Immunomodulartory Effect :-mentioning

confidence: 99%

“…The etiology of periodontitis is known to be multifactorial. The use of tulsi in the treatment of periodontal disease shows a marked reduction in the progression of the disease through various mechanisms like anti-inflammatory, antimicrobial, antiplaque agents, antioxidants, and immunomodulatory agents at different concentrations [8,12,13,16]. The dried, powdered leaves of tulsi were used for brushing [2,3].…”

Section: Periodontitis :-mentioning

confidence: 99%

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Therapeutic Uses of Tulsi ( Ocimum Sanctum ) in Oral Lesions

Janakiraman,

Mohaideen,

et al. 2023

PIJR

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Since ancient times, plants have been used for various medicinal purposes in treating various diseases. Oral diseases are among the major public health problems and the most common of the chronic diseases that affect mankind. The application of natural products for the control of oral diseases is considered an interesting alternative to synthetic antimicrobials due to their lower negative impact. Ocimum sanctum (Tulsi) is a plant with enormous properties for curing and preventing diseases through its greater medicinal value. This article reviews the therapeutic role of Tulsi (Ocimum sanctum) in various oral lesions

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Anti-inflammatory, anti-oxidant effect and cytotoxicity of Ocimum sanctum intra oral gel for combating periodontal diseases

Cited by 8 publications

References 10 publications

Comparative clinical data for gingivitis treatment using gels from Ocimum sanctum (Tulsi) and chlorhexidine (CHX)

Comparative clinical data for gingivitis treatment using gels from Ocimum sanctum (Tulsi) and chlorhexidine (CHX)

Exploring Synergies of Lotus Seed Extract-Hyaluronic Acid Gel for Enhanced Local Drug Delivery

Therapeutic Uses of Tulsi ( Ocimum Sanctum ) in Oral Lesions

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