1994
DOI: 10.7547/87507315-84-2-77
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Anti-inflammatory and wound healing activity of a growth substance in Aloe vera

Abstract: Aloe vera improves wound healing and inhibits inflammation. Since mannose-6-phosphate is the major sugar in the Aloe gel, the authors examined the possibility of its being an active growth substance. Mice receiving 300 mg/kg of mannose-6-phosphate had improved wound healing over saline controls. This dose also had anti-inflammatory activity. The function of mannose-6-phosphate in A. vera is discussed.

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Cited by 222 publications
(142 citation statements)
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“…This decrease of inflammation observed may also be explained by the anti-inflammatory property of Aloe vera, through the immunomodulatory effect of the polysaccharides acetylated mannose (mannose-6-phosphate), acemannan and veraciglucans A, B and C, according to the findings of other studies [16][17][18][19][20] .…”
Section: Discussionmentioning
confidence: 68%
See 1 more Smart Citation
“…This decrease of inflammation observed may also be explained by the anti-inflammatory property of Aloe vera, through the immunomodulatory effect of the polysaccharides acetylated mannose (mannose-6-phosphate), acemannan and veraciglucans A, B and C, according to the findings of other studies [16][17][18][19][20] .…”
Section: Discussionmentioning
confidence: 68%
“…The data were processed in the Statistical Package for the Social Sciences (SPSS) program version 16…”
Section: Discussionmentioning
confidence: 99%
“…Similarly, Liu et al, 37 found that AV increased fibroblast proliferation and collagen synthesis, and elevated hyaluronic acid and hydroxyproline level, which suggest a possible role in the extracellular matrix remodeling during wound healing. Another study attributed the effect of AV to the binding of mannose-6-phosphate, an essential component of AV, to fibroblast receptors, activating their proliferation, 38 thus stimulating collagen synthesis and increasing the healing area. 39 The decrease in the number of activated fibroblasts and mature vascular endothelial cells at the 7th day might be related to the almost complete healing process.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, these membranes accelerated significantly wound closure and re-epithelisation in an in vivo full thickness wound healing assay carried out on db/db mice. The wound healing property of Aloe vera gel has been attributed by some to the content of mannose-6-phosphate (73). It has been reported also that the wound-healing capacity may be attributed partially due to presence of mannose-6-phosphate, glucomannan, and gibberellin, a growth hormone (74).…”
Section: Woundsmentioning
confidence: 98%
“…The authors reported that patients treated with the Aloe vera gel experienced faster healing and better pain relief than patients treated with the silver sulphadiazine. In vivo analysis of burn injuries demonstrates that Aloe vera gel acts as an inhibitor of thromboxane A2, which is a mediator of progressive tissue damage (73). It was reported that in vivo, Aloe vera gel used in the treatment of chronic ulcers stimulates and accelerates skin burn healing (112)(113)(114).…”
Section: Accidental Burnsmentioning
confidence: 99%