Anti-inflammatory and wound healing activity of a growth substance in Aloe vera

Rm, Davis; Donato, J. L.; Hartman, G. Paul; Haas, R

doi:10.7547/87507315-84-2-77

Cited by 222 publications

(142 citation statements)

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“…This decrease of inflammation observed may also be explained by the anti-inflammatory property of Aloe vera, through the immunomodulatory effect of the polysaccharides acetylated mannose (mannose-6-phosphate), acemannan and veraciglucans A, B and C, according to the findings of other studies [16][17][18][19][20] .…”

Section: Discussionmentioning

confidence: 68%

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Aloe vera as vehicle to mineral trioxide aggregate: study in bone repair

Fé

Coelho

Damascena

et al. 2014

Rev. odontol. UNESP

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AIM: Mineral trioxide aggregate (MTA) was associated to Aloe vera to verify the coadjutant action of that medicinal plant in the bone neoformation process in tibia of rats.MATERIAL AND METHOD: 36 male rats (Rattus norvegicus) were used, divided into two groups of 18 rats each. Two circumferential bone defects with approximately 5 mm in diameter were made on the right tibia of each animal: the upper defect was filled with blood coagulates in both groups to serve as experimental control and the lower defect was filled with MTA and Aloe vera in experimental (group E1) and MTA and distilled water in experimental (group E2). Seven, 15 and 30 days after surgery, six animals from each group were euthanized and the right tibia of each animal was removed for histological analysis.RESULT: Histologically, experimental group E1 presented better results for the two variables, inflammation [at seven days (p=0.045)] and bone formation [at seven days (p=0.018) and 30 days (p=0.034)], compared to the E2 group.CONCLUSION: The association of MTA and Aloe vera showed potential to reduce the effects of the inflammatory cascade and promote bone neoformation making it to a promising proposal for future use in endodontic therapy.

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Section: Discussionmentioning

confidence: 68%

“…The data were processed in the Statistical Package for the Social Sciences (SPSS) program version 16…”

Section: Discussionmentioning

confidence: 99%

Aloe vera as vehicle to mineral trioxide aggregate: study in bone repair

Fé

Coelho

Damascena

et al. 2014

Rev. odontol. UNESP

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“…Similarly, Liu et al, 37 found that AV increased fibroblast proliferation and collagen synthesis, and elevated hyaluronic acid and hydroxyproline level, which suggest a possible role in the extracellular matrix remodeling during wound healing. Another study attributed the effect of AV to the binding of mannose-6-phosphate, an essential component of AV, to fibroblast receptors, activating their proliferation, 38 thus stimulating collagen synthesis and increasing the healing area. 39 The decrease in the number of activated fibroblasts and mature vascular endothelial cells at the 7th day might be related to the almost complete healing process.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect of Aloe vera and silver nanoparticles on acid-induced oral ulcer in gamma-irradiated mice

El-Batal

Ahmed

2018

Braz. oral res.

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Radiation combined injury, a life-threatening condition, has higher mortality than simple radiation injury. The aim of the present study was to analyze the efficiency of Aloe vera and silver nanoparticles in improving the healing of ulcerated oral mucosa after irradiation. Thirty male Albino mice were divided into five groups: control, radiation, Aloe vera (AV), silver nanoparticles (NS), and AV+NS. The mice were exposed to whole body 6Gy gamma-radiation. After one hour, 20% acetic acid was injected into the submucosal layer of the lower lip for ulcer induction. The animals received topical treatment with the assigned substances for 5 days. Lip specimens were subjected to hematoxylin and eosin and anti alpha-smooth muscle actin immunohistochemical staining. Results demonstrated occurance of ulcer three days post irradiation in all groups except in the AV+NS group where only epithelial detachment was developed. After seven days, data revealed persistent ulcer in radiation group, and almost normal epithelium in the AV+NS group. A significant reduction of epithelial thickness was detected in all groups at the third day as compared to control. At the seventh day, only the AV+NS group restored the epithelial thickness. Area percent of alpha-smooth muscle actin expression was significantly decreased in radiation group at the third day followed by significant increase at the seventh day. However, all treatment groups showed significant increase in alpha-smooth muscle actin at the third day, which decreased to normal level at the seventh day. Our study demonstrated the efficiency of Aloe vera and silver nanoparticles in enhancing ulcer healing after irradiation.

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“…Furthermore, these membranes accelerated significantly wound closure and re-epithelisation in an in vivo full thickness wound healing assay carried out on db/db mice. The wound healing property of Aloe vera gel has been attributed by some to the content of mannose-6-phosphate (73). It has been reported also that the wound-healing capacity may be attributed partially due to presence of mannose-6-phosphate, glucomannan, and gibberellin, a growth hormone (74).…”

Section: Woundsmentioning

confidence: 98%

“…The authors reported that patients treated with the Aloe vera gel experienced faster healing and better pain relief than patients treated with the silver sulphadiazine. In vivo analysis of burn injuries demonstrates that Aloe vera gel acts as an inhibitor of thromboxane A2, which is a mediator of progressive tissue damage (73). It was reported that in vivo, Aloe vera gel used in the treatment of chronic ulcers stimulates and accelerates skin burn healing (112)(113)(114).…”

Section: Accidental Burnsmentioning

confidence: 99%