Anti-inflammatory and Immunomodulatory Effects of Ulomoides dermestoides on Induced Pleurisy in Rats and Lymphoproliferation In Vitro

Santos, Roberto Christ Vianna; Lunardelli, Adroaldo; Caberlon, Eduardo; Bastos, Carolina Maria Alves; Nunes, Fernanda Bordignon; Pires, Marçal; Biolchi, Vanderlei; Paul, Elisiane Lozza; Vieira, Francesco Breno Campolongo; Aquino, Alzira Resende do Carmo; Corseuil, Élio; Oliveira, Jarbas Rodrigues de

doi:10.1007/s10753-009-9171-x

Cited by 33 publications

(27 citation statements)

References 22 publications

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“…Carrageenan-induced pleurisy is a well characterized experimental model of inflammation that permits the quantification and correlation of both exudate and cellular migration with changes of other inflammatory parameters (Santos et al 2010). This model has been widely used to investigate the pathophysiology of acute inflammation and also to evaluate the efficacy of drugs in inflammation (Paul et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil

Silva

Luft

Lunardelli

et al. 2015

An. Acad. Bras. Ciênc.

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122

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Several studies have investigated the antinociceptive, immunomodulatory and anti-inflammatory properties of compounds found in the lavender essential oil (LEO), however to date, there is still lack of substantial data. The objective of this study was to assess the antioxidant, anti-inflammatory and antinociceptive effects of lavender essential oil. The 1,1-diphenyl-2-picrylhydrazyl radical decolorization assay was used for antioxidant activity evaluation. The anti-inflammatory activity was tested using two models of acute inflammation: carrageenan-induced pleurisy and croton oil-induced ear edema. The antinociceptive activity was tested using the pain model induced by formalin. LEO has antioxidant activity, which is dose-dependent response. The inflammatory response evoked by carrageenan and by croton oil was reduced through the pre-treatment of animals with LEO. In the pleurisy model, the drug used as positive control, dexamethasone, was more efficacious. However, in the ear swelling, the antiedematogenic effect of the oil was similar to that observed for dexamethasone. In the formalin test, LEO consistently inhibited spontaneous nociception and presented a similar effect to that of tramadol. The results of this study reveal (in vivo) the analgesic and anti-inflammatory activities of LEO and demonstrates its important therapeutic potential.

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Section: Discussionmentioning

confidence: 99%

Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil

Silva

Luft

Lunardelli

et al. 2015

An. Acad. Bras. Ciênc.

Self Cite

122

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“…Often, the inflammatory response to severe lesions erroneously damages normal tissue [20]. Carrageenaninduced pleurisy, a well-established inflammation model, is commonly used to investigate pathophysiology of acute inflammation, which allowed quantification and correlation of both exudate and cellular migration with changes of other inflammatory parameters [21]. Recruitment of cells to inflammatory sites is dependent on the release of vasoactive and chemotactic factors that increase regional blood flow and microvascular permeability and promote the migration of leukocytes from the intravascular space into the tissues [22].…”

Section: Discussionmentioning

confidence: 99%

Modulation of Inflammatory Processes by Leaves Extract from Clusia nemorosa Both In Vitro and In Vivo Animal Models

et al. 2011

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The present study was carried out to investigate the anti-inflammatory effect of the hexane extract of the leaves from Clusia nemorosa G. Mey, called HECn, using carrageenan-induced mice pleurisy and cotton pellet-induced mice granuloma. Additionally, the ability of HECn to affect both neutrophil migration as viability was investigated by use of the Boyden chamber assay and flow cytometry, respectively. The HECn significantly inhibited exudation, total leukocytes and neutrophils influx, as well as TNFα levels in carrageenan-induced pleurisy. However, the extract not suppressed the granulomatous tissue formation in the cotton pellet-induced granuloma test. Experiments performed in vitro revealed that HECn on human neutrophils inhibited a dose-dependent manner the CXCL1-induced neutrophil chemotaxis. Furthermore, HECn also inhibited the chemoattraction of human neutrophils induced by formyl-methionyl-leucyl-phenylalanine (fMLP), leukotriene B4 (LTB4) and platelet activating factor (PAF) in a Boyden chamber. However, this same treatment not was able to induce apoptosis. The results obtained in this study showed that the extract from leaves of C. nemorosa possess a potent inhibitory activity in acute model of inflammation, being the effects mediated, in part, by inhibition of neutrophil responsiveness. These results indicate that C. nemorosa could be a good source for anti-inflammatory compounds.

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“…The cells were treated with either isolated NAC concentrations (1 mM; 5 mM; 10 mM; 15 mM) or associated with FBP (1.25 mM) (n = 6 for each concentration). The cellular viability was performed by Trypan Blue dye exclusion after 96 hours of incubation (26,32) . The results are presented as percentage ± SEM.…”

Section: Cytotoxicity Analysismentioning

confidence: 99%