Anti-inflammatory and immunomodulatory effects of antibiotics and their use in dermatology

Pradhan, Swetalina; Madke, Bhushan; Kabra, Poonam; Singh, Adarshlata

doi:10.4103/0019-5154.190105

Cited by 74 publications

(27 citation statements)

References 133 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some authors advocate that they act by eradicating H. pylori , whereas others highlight a non-specific direct benefit from the use of antibiotics as the cause of clinical improvement. The confusion is further enhanced by the fact that some of the antibiotics known for their anti-inflammatory properties in rosacea, such as tetracyclines, metronidazole or macrolides, 67 are also used to treat H. pylori infection. 68 Moreover, different studies have used different statistical methods which could constitute a further explanation for the controversial conclusions, taking also into account that much evidence is derived from case series with a small number of participants.…”

Section: Discussionmentioning

confidence: 99%

Rosacea and Helicobacter pylori: links and risks

Lazaridou¹,

Korfitis²,

Kemanetzi³

et al. 2017

CCID

View full text Add to dashboard Cite

Rosacea is a chronic skin disease characterized by facial erythema and telangiectasia. Despite the fact that many hypotheses have been proposed, its etiology remains unknown. In the present review, the possible link and clinical significance of Helicobacter pylori in the pathogenesis of rosacea are being sought. A PubMed and Google Scholar search was performed using the terms “rosacea”, “H.pylori”, “gastrointestinal disorders and H.pylori”, “microorganisms and rosacea”, “pathogenesis and treatment of rosacea”, and “risk factors of rosacea”, and selected publications were studied and referenced in text. Although a possible pathogenetic link between H. pylori and rosacea is advocated by many authors, evidence is still interpreted differently by others. We conclude that further studies are needed in order to fully elucidate the pathogenesis of rosacea.

show abstract

Section: Discussionmentioning

confidence: 99%

Rosacea and Helicobacter pylori: links and risks

Lazaridou¹,

Korfitis²,

Kemanetzi³

et al. 2017

CCID

View full text Add to dashboard Cite

show abstract

“…Other potential rationales for the use of clindamycin in COVID-19 patients can be attributed to its anti-inflammatory and immunomodulatory effects. Clindamycin was reported to modulate cytokine production in lipopolysaccharide-stimulated macrophages, to decrease TNF-α and IL-1β, to suppress the chemotaxis of polymorphonuclear leukocytes, to reduce inflammation, and to enhance the uptake of microorganisms by the host phagocytic cells [ 137 ]. It is also possible that it is being tested for antibacterial coverage in hospitalized patients with COVID-19-related pneumonia.…”

Section: Potential Small Molecule Inhibitors Of Early Viral Eventsmentioning

confidence: 99%

Potential Anti-COVID-19 Therapeutics that Block the Early Stage of the Viral Life Cycle: Structures, Mechanisms, and Clinical Trials

Al‐Horani

Kar

Aliter

2020

IJMS

View full text Add to dashboard Cite

The ongoing pandemic of coronavirus disease-2019 (COVID-19) is being caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The disease continues to present significant challenges to the health care systems around the world. This is primarily because of the lack of vaccines to protect against the infection and the lack of highly effective therapeutics to prevent and/or treat the illness. Nevertheless, researchers have swiftly responded to the pandemic by advancing old and new potential therapeutics into clinical trials. In this review, we summarize potential anti-COVID-19 therapeutics that block the early stage of the viral life cycle. The review presents the structures, mechanisms, and reported results of clinical trials of potential therapeutics that have been listed in clinicaltrials.gov. Given the fact that some of these therapeutics are multi-acting molecules, other relevant mechanisms will also be described. The reviewed therapeutics include small molecules and macromolecules of sulfated polysaccharides, polypeptides, and monoclonal antibodies. The potential therapeutics target viral and/or host proteins or processes that facilitate the early stage of the viral infection. Frequent targets are the viral spike protein, the host angiotensin converting enzyme 2, the host transmembrane protease serine 2, and clathrin-mediated endocytosis process. Overall, the review aims at presenting update-to-date details, so as to enhance awareness of potential therapeutics, and thus, to catalyze their appropriate use in combating the pandemic.

show abstract

“…Several antibiotics, including minocycline and macrolides, present with both antimicrobial and anti-inflammatory properties as they de-escalate NLRP3 (Pradhan et al, 2016). Recent studies have shown that minocycline also presents with senolytic properties as aside from inhibiting NLRP3, it facilitates senescent cell removal (Labro, 2002; Li J. et al, 2016; Lee et al, 2017).…”

Section: Beta Amyloid: Friend or Foe?mentioning

confidence: 99%

The Post-amyloid Era in Alzheimer's Disease: Trust Your Gut Feeling

Osorio

Kanukuntla

Diaz

et al. 2019

Front. Aging Neurosci.

View full text Add to dashboard Cite

The amyloid hypothesis, the assumption that beta-amyloid toxicity is the primary cause of neuronal and synaptic loss, has been the mainstream research concept in Alzheimer's disease for the past two decades. Currently, this model is quietly being replaced by a more holistic, “systemic disease” paradigm which, like the aging process, affects multiple body tissues and organs, including the gut microbiota. It is well-established that inflammation is a hallmark of cellular senescence; however, the infection-senescence link has been less explored. Microbiota-induced senescence is a gradually emerging concept promoted by the discovery of pathogens and their products in Alzheimer's disease brains associated with senescent neurons, glia, and endothelial cells. Infectious agents have previously been associated with Alzheimer's disease, but the cause vs. effect issue could not be resolved. A recent study may have settled this debate as it shows that gingipain, a Porphyromonas gingivalis toxin, can be detected not only in Alzheimer's disease but also in the brains of older individuals deceased prior to developing the illness. In this review, we take the position that gut and other microbes from the body periphery reach the brain by triggering intestinal and blood-brain barrier senescence and disruption. We also surmise that novel Alzheimer's disease findings, including neuronal somatic mosaicism, iron dyshomeostasis, aggressive glial phenotypes, and loss of aerobic glycolysis, can be explained by the infection-senescence model. In addition, we discuss potential cellular senescence targets and therapeutic strategies, including iron chelators, inflammasome inhibitors, senolytic antibiotics, mitophagy inducers, and epigenetic metabolic reprograming.

show abstract

Anti-inflammatory and immunomodulatory effects of antibiotics and their use in dermatology

Cited by 74 publications

References 133 publications

Rosacea and Helicobacter pylori: links and risks

Rosacea and Helicobacter pylori: links and risks

Potential Anti-COVID-19 Therapeutics that Block the Early Stage of the Viral Life Cycle: Structures, Mechanisms, and Clinical Trials

The Post-amyloid Era in Alzheimer's Disease: Trust Your Gut Feeling

Contact Info

Product

Resources

About