Anti‐inflammatory and immune‐modulatory impacts of berberine on activation of autoreactive T cells in autoimmune inflammation

Ehteshamfar, Seyed-Morteza; Akhbari, Masoume; Afshari, Jalil Tavakol; Seyedi, Motahareh; Nikfar, Banafsheh; Shapouri‐Moghaddam, Abbas; Ghanbarzadeh, Erfan

doi:10.1111/jcmm.16049

Cited by 78 publications

(66 citation statements)

References 189 publications

(407 reference statements)

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“…The transcription factor of Treg cells and FoxP3 plays an anti-inflammatory role by mediating the release of IL-10 and TGF- β 1 and maintaining tolerance to its own or foreign components [ 17 ]. Interestingly, ROR γτ can inhibit the differentiation of Treg cells while FoxP3 can do the same to Th17, which reflects that they antagonize each other and maintain balance in immunity [ 18 ]. It is quite worthy to note that the paralesion area is quite pivotal for both immune response and clinical decision-making process.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, there are few effective means to predict the curative effect of albendazole. It is now well accepted that 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) is the only diagnostic method evaluating the metabolic activity of AE lesions [5,6]. PET scan not only determines the boundary of the lesion but also assesses metabolic activity.…”

Section: Introductionmentioning

confidence: 99%

“…It could provide clinicians with a critical reference that was helpful in evaluating the therapeutic effects and optimizing the clinical strategies. However, 18 F-FDG PET/CT costs much and is too hard to maintain. Especially for majority of AE patients from poorly resourced areas, it is not readily available.…”

Section: Introductionmentioning

confidence: 99%

“…Especially for majority of AE patients from poorly resourced areas, it is not readily available. In this background, our previous study pointed out that plasma IL-23 combined with IL-5 could be a marker indicating lesion metabolic activity with similar prognostic values as good as 18 F-FDG PET/CT in patients with hepatic AE [7]. Plasma IL-23 measurement is a minimally invasive, accessible, and affordable technique especially for poverty.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Albendazole on Cytokine and Chemokine Response Profiles in Echinococcus multilocularis-Inoculated Mice

Apaer

et al. 2021

BioMed Research International

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Objective. Alveolar echinococcosis (AE) is a zoonosis caused by the larval stage of the metacestode Echinococcosis multilocularis with a tumor-like behavior in the targeted organ, especially in the liver. Surgery with albendazole is first-line modality for AE. Drug discontinuation is usually based upon the parasitic viability shown by the positron emission tomography (PET) scan. However, as a demanding and expensive method, it is not widely practiced in majority of the endemic regions. Further understanding on the cytokine and chemokine response profiles in AE patients may provide an interesting insight for potential markers in viability assessment. Methods. Mice were inoculated with Echinococcus multilocularis intrahepatically to develop the hepatic AE murine model. Oral albendazole administration was then applied for three months after the first inoculation, and peripheral and regional immune cells including type 1 T helper cells (Th), Th2, Th17, regulatory T (Treg) cells, related cytokines, and chemokines were examined. Results. The hepatic AE lesion was confirmed by ultrasound examination resulting in a successful rate of 70%. Among the 17 cytokines and chemokines detected, plasma levels of IL-23 were significantly higher in E. multilocularis-infected mice when compared to the control group; furthermore, more obvious increasing levels were found after albendazole treatment ( p < 0.05 ). All chemokine levels other than eotaxin and MCP-3 were slightly higher in E. multilocularis-infected mice compared to the control group ( p > 0.05 ). Eotaxin levels were significantly decreased in mice with E. multilocularis infection followed by albendazole treatment ( p < 0.05 ). Both IL-17A and IL-23 expressions in hepatic AE lesions were significantly higher and related with disease activity. Conclusion. Albendazole administration influenced the balance of immune response and promotes the secretion of proinflammatory factors which is beneficial to parasite clearance. IL-23 seems to be associated with the successful albendazole treatment in mice with E. multilocularis infection; such a change could be translated into clinical application in the near future.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of Albendazole on Cytokine and Chemokine Response Profiles in Echinococcus multilocularis-Inoculated Mice

Apaer

et al. 2021

BioMed Research International

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“…Simultaneously, various therapeutic activities have been ascribed to alkaloids, including antioxidant, cancer-preventive, antidiabetic, anti-inflammatory, and vasodilatory activities (252)(253)(254), but it has not been well-investigated how livestock could benefit from these beneficial activities from alkaloids. Many plant extracts that have been investigated for the beneficial actions of contained polyphenols and terpenoids may also contain alkaloids contributing to their biological activities, for example, giant milkweed (255) or herbal mixtures containing polyphenols, terpenoids, and alkaloids (256).…”

Section: Nutritional Importancementioning

confidence: 99%

Nutritional Aspects of Ecologically Relevant Phytochemicals in Ruminant Production

Tedeschi

Muir²,

Naumann

et al. 2021

Front. Vet. Sci.

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This review provides an update of ecologically relevant phytochemicals for ruminant production, focusing on their contribution to advancing nutrition. Phytochemicals embody a broad spectrum of chemical components that influence resource competence and biological advantage in determining plant species' distribution and density in different ecosystems. These natural compounds also often act as plant defensive chemicals against predatorial microbes, insects, and herbivores. They may modulate or exacerbate microbial transactions in the gastrointestinal tract and physiological responses in ruminant microbiomes. To harness their production-enhancing characteristics, phytochemicals have been actively researched as feed additives to manipulate ruminal fermentation and establish other phytochemoprophylactic (prevent animal diseases) and phytochemotherapeutic (treat animal diseases) roles. However, phytochemical-host interactions, the exact mechanism of action, and their effects require more profound elucidation to provide definitive recommendations for ruminant production. The majority of phytochemicals of nutritional and pharmacological interest are typically classified as flavonoids (9%), terpenoids (55%), and alkaloids (36%). Within flavonoids, polyphenolics (e.g., hydrolyzable and condensed tannins) have many benefits to ruminants, including reducing methane (CH4) emission, gastrointestinal nematode parasitism, and ruminal proteolysis. Within terpenoids, saponins and essential oils also mitigate CH4 emission, but triterpenoid saponins have rich biochemical structures with many clinical benefits in humans. The anti-methanogenic property in ruminants is variable because of the simultaneous targeting of several physiological pathways. This may explain saponin-containing forages' relative safety for long-term use and describe associated molecular interactions on all ruminant metabolism phases. Alkaloids are N-containing compounds with vast pharmacological properties currently used to treat humans, but their phytochemical usage as feed additives in ruminants has yet to be exploited as they may act as ghost compounds alongside other phytochemicals of known importance. We discussed strategic recommendations for phytochemicals to support sustainable ruminant production, such as replacements for antibiotics and anthelmintics. Topics that merit further examination are discussed and include the role of fresh forages vis-à-vis processed feeds in confined ruminant operations. Applications and benefits of phytochemicals to humankind are yet to be fully understood or utilized. Scientific explorations have provided promising results, pending thorough vetting before primetime use, such that academic and commercial interests in the technology are fully adopted.

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Ultrasound‐Controlled Electron‐Phonon Coupling Augmenting Catalysis of Piezoelectric‐Based Sonosensitizer Safely Against Osteomyelitis

Zhu

et al. 2023

Adv Funct Materials

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The energy transfer way and efficiency of ultrasound (US) to piezoelectric materials in fluid determines the US catalytic performance of materials and the subsequent sono‐therapeutic effects for deep infection diseases. Herein, on insonation, the microbubble cavitation occurs near the surface of barium orthotitanate/berberine chloride nanoparticles (BTO/Ber NPs), often forming sonoluminescence and high pressure. The light further activates Ber, and the electron transfer happens between activated Ber and changing energy levels of BTO NPs caused by changing pressure. Meanwhile, ultrasound‐driven piezoelectric electron‐phonon coupling simultaneously narrows bandgap and prolongates carrier‐lifetime, leading to more ROS generation. Hence, BTO/Ber NPs show great antibacterial activity against Staphylococcus aureus (99.80 ± 0.09%) by microbubble‐mediated sonoporation and catalysis. Meanwhile, BTO/Ber NPs improve bone regeneration by decreasing the inflammatory response and enhancing osteoblast differentiation. US‐mediated microbubbles may offer a safe and efficient treatment to millions of patients suffering from osteomyelitis and pave the way for the highly safe use of ultrasound in deep infections.

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Anti‐inflammatory and immune‐modulatory impacts of berberine on activation of autoreactive T cells in autoimmune inflammation

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 78 publications

References 189 publications

Impact of Albendazole on Cytokine and Chemokine Response Profiles in Echinococcus multilocularis-Inoculated Mice

Impact of Albendazole on Cytokine and Chemokine Response Profiles in Echinococcus multilocularis-Inoculated Mice

Nutritional Aspects of Ecologically Relevant Phytochemicals in Ruminant Production

Ultrasound‐Controlled Electron‐Phonon Coupling Augmenting Catalysis of Piezoelectric‐Based Sonosensitizer Safely Against Osteomyelitis

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