Anti-inflammatory and hypoglycemic activities of alpha-pinene

Özbek, Hanefí; Yılmaz, Bilal

doi:10.23893/1307-2080.aps.05522

Cited by 25 publications

(16 citation statements)

References 13 publications

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“…According to [ 57 , 58 ], α-pinene can act as an anti-inflammatory via the suppression of IL-1β, NF-κB, and iNOS and nuclear translocation of NF-kappa B. The documented in vivo results of α-pinene revealed the fact of the significant role of this compound as an anti-inflammatory agent even at high and/or low concentrations [ 59 ]. Several documents deduced this role of α-pinene as a widely distributed compound in ABSEOs.…”

Section: Discussionmentioning

confidence: 99%

Oral and Topical Anti-Inflammatory and Antipyretic Potentialities of Araucaria bidiwillii Shoot Essential Oil and Its Nanoemulsion in Relation to Chemical Composition

et al. 2021

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Different parts of Araucaria bidiwillii (bunya pin) trees, such as nuts, seeds, bark, and shoots, are widely used in cooking, tea, and traditional medicines around the world. The shoots essential oil (EO) has not yet been studied. Herein, the chemical profile of A. bidiwillii shoots EO (ABSEO) was created by GC–MS analysis. Additionally, the in vivo oral and topical anti-inflammatory effect against carrageenan-induced models, as well as antipyretic potentiality of ABSEO and its nanoemulsion were evaluated. Forty-three terpenoid components were identified and categorized as mono- (42.94%), sesqui- (31.66%), and diterpenes (23.74%). The main compounds of the ABSEO were beyerene (20.81%), α-pinene (16.21%), D-limonene (14.22%), germacrene D (6.69%), β-humulene (4.14%), and sabinene (4.12%). The ABSEO and its nanoemulsion exhibited significant inflammation suppression in carrageenan-induced rat paw edema model, in both oral (50 and 100 mg/kg) and topical (5% in soyabean oil) routes, compared to the control and reference drugs groups. All the results demonstrated the significant inflammation reduction via the inflammatory cytokines (IL-1β and IL8), nitrosative (NO), and prostaglandin E2 (PGE2) supported by the histopathological studies and immunohistochemical assessment of MMP-9 and NF-κβ levels in paw tissues. Moreover, the oral administration of ABSEO and its nanoemulsion (50 and 100 mg/kg) exhibited antipyretic activity in rats, demonstrated by the inhibition of hyperthermia induced by intramuscular injection of brewer’s yeast. These findings advised that the use of ABSEO and its nanoemulsion against numerous inflammatory and hyperthermia ailments that could be attributed to its active constituents.

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Section: Discussionmentioning

confidence: 99%

Oral and Topical Anti-Inflammatory and Antipyretic Potentialities of Araucaria bidiwillii Shoot Essential Oil and Its Nanoemulsion in Relation to Chemical Composition

et al. 2021

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“…The volatile compounds α-pinene and β-pinene were also found in high concentrations in the present study and have been evaluated for biological activities. Both compounds presented antibacterial, antiviral, antifungal and hypotensive activities [48], α-pinene presented anti-inflammatory, hypoglycemic [49], and gastroprotective activities [50] whereas β-pinene showed antidepressant [51] and antiviral [52] properties.…”

Section: Yield and Chemical Composition Of Essential Oil (Eo)mentioning

confidence: 99%

Ocotea porosa: Anatomy and Histochemistry of Leaves and Stems, Chemical Composition, Cytotoxicity and Insecticidal Activities of Essential Oil

Brustulim

Monteiro

Almeida

et al. 2020

Braz. arch. biol. technol.

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Ocotea porosa (Nees & Mart.) Barroso, commonly known as "imbuia", "canela-imbuia" or "imbuiaamarela" in Brazil, is a tree of the Southern Atlantic Forest. The present study investigates the anatomy of leaf and stem, volatile oil chemistry, as well as cytotoxicity and insecticidal activities of the essential oil of O. porosa. Species identification was achieved by anatomy features, mainly due to paracytic and anomocytic stomata; non-glandular trichomes; biconvex midrib and petiole with a collateral open arc vascular bundle; presence of a sclerenchymatous layer, starch grains and crystal sand in the stem; and the presence of HIGHLIGHTS  The anatomy features were useful for identification of Ocotea porosa.  The major volatile compounds were α-pinene, β-pinene and bicyclogermacrene.  Essential oil of O. porosa was cytotoxic against McCoy, B16F10 and MCF7cell lines.  The cytotoxic mechanism might be related to apoptotic events.  Insert 1-4 highlights no longer than 85 characters.  Insert a highlight no longer than 85 characters.  Insert a highlight no longer than 85 characters. • Insert a highlight no longer than 85 characters.

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“…Several terpenes identified in F. nodosa essential oil are able to exert hypoglycemic and hypolipidemic activity. The intraperitoneal administration of α-pinene in diabetic mice at different doses (0.05, 0.10, 0.25 and 0.50 mL/kg) resulted in a reduction of fasting blood glucose levels [ 42 ]. Previously, Bae et al [ 43 ] demonstrated that intraperitoneal administration of α-pinene (5, 25, or 50 mg/kg) reduced body weight and the serum levels of α-amylase and lipase.…”

Section: Resultsmentioning

confidence: 99%

Ferulago nodosa Subsp. geniculata (Guss.) Troia & Raimondo from Sicily (Italy): Isolation of Essential Oil and Evaluation of Its Bioactivity

et al. 2020

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Ferulago nodosa (L.) Boiss. (Apiaceae) is a species occurring in the Balkan-Tyrrhenian area. The object of the present study is Sicilian F. nodosa subsp. geniculata (Guss.) Troia & Raimondo, classified as an endemic F. nodosa subspecies. Aerial parts of this plant species were subjected to hydrodistillation to obtain an essential oil. A total of 93 compounds were identified with 2,3,6-trimethyl benzaldehyde (19.0%), spathulenol (9.0%), (E)-caryophyllene (5.4%), and caryophyllene oxide (5.4%) as the main components. The biological activities of F. nodosa essential oil were also investigated. This oil showed an interesting antioxidant potential in a 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) test (IC50 of 14.05 μg/mL). Additionally, hypoglycemic and antilipidemic effects were evaluated. Lipase enzyme was inhibited with an IC50 value of 41.99 μg/mL. Obtained data demonstrated that F. nodosa could be considered a promising source of bioactive compounds useful for the treatment and management of obesity.

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Anti-inflammatory and hypoglycemic activities of alpha-pinene

Cited by 25 publications

References 13 publications

Oral and Topical Anti-Inflammatory and Antipyretic Potentialities of Araucaria bidiwillii Shoot Essential Oil and Its Nanoemulsion in Relation to Chemical Composition

Oral and Topical Anti-Inflammatory and Antipyretic Potentialities of Araucaria bidiwillii Shoot Essential Oil and Its Nanoemulsion in Relation to Chemical Composition

Ocotea porosa: Anatomy and Histochemistry of Leaves and Stems, Chemical Composition, Cytotoxicity and Insecticidal Activities of Essential Oil

Ferulago nodosa Subsp. geniculata (Guss.) Troia & Raimondo from Sicily (Italy): Isolation of Essential Oil and Evaluation of Its Bioactivity

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