Anti-inflammatory and Hepatoprotective Potentials of Methanol Leaf Extract of Arachis hypogea

Ibeh, RC; Aloh, G. S.; Ikechukwu, Gavin C.; Ebhohon, Shirley; Edward, U. I.; Njoku, Carol Ijeoma; Azubike-Izah, F. O.; Ejiofor, Emmanuel U.; Nwankwo, C. A.; Oriaku, Chinwe E.

doi:10.9734/bjpr/2017/33210

Cited by 1 publication

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References 26 publications

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“…This study evaluated hepatocellular enzyme activities, hepatic function parameters and antioxidative activity of alloxan-induced diabetic rats administered Acioa barteri extract (ABE). Early detection of diabetes mellitus, lifestyle changes, dietary restriction, and monitoring of blood glucose levels and organ functions including medical interventions remain the major steps towards successful management of diabetes mellitus (Ibeh et al, 2020). While some conventional therapies may not be harmful to the kidneys or liver, studies have shown the beneficial effect of medicinal plants in reducing kidney and liver damage, either alone or in combination with conventional therapy (Nwankpa et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Assessment of Hepatoprotective and Antioxidant Effect of Acioa barteri Extract (ABE) in Alloxan-Induced Diabetic Rats

Uroko,

Ogbonna,

Aguwamba

et al. 2024

Trad.Med.J

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This study aimed to investigate the effects of Acioa barteri extract (ABE) on hepatocellular enzyme activity, hepatic function, and antioxidant stress indices in diabetic rats induced with alloxan. The antidiabetic effect of ABE was evaluated in six experimental groups: normal controls, diabetics untreated, diabetics treated with 200mg/kg, 400mg/kg, or 800 mg/kg ABE, and diabetics treated with 3 mg/kg Glibenclamide. ABE was orally administered to induce diabetes, and alloxan-monohydrate was intraperitoneally administered. Diabetic untreated rats exhibited significantly elevated levels of alkaline phosphatase, aspartate, and alanine transaminase activities, as well as higher concentrations of total bilirubin, conjugated bilirubin, and malondialdehyde. They also showed decreased levels of total protein, albumin, globulin, and protein-bound iodine, along with reduced antioxidant enzyme activity. In contrast, diabetic rats administered ABE demonstrated reduced hepatocellular enzyme activity and improved hepatic function. These rats exhibited increased levels of total protein, globulin, and albumin, as well as higher levels of glutathione, superoxide dismutase, glutathione peroxidase, and catalase activities, compared to diabetic untreated rats. The findings suggest that ABE may help prevent oxidative stress and improve hepatic functions in diabetic rats. ABE treatment led to decreased hepatocellular enzyme activity and improved hepatic function, along with increased antioxidant enzyme activities. These results highlight the potential of ABE as a therapeutic option for diabetes-induced liver dysfunction. Further research is warranted to explore its mechanisms of action and potential clinical applications.

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Section: Discussionmentioning

confidence: 99%