Anti-inflammatory and hepatoprotective effects of Ganoderma lucidum polysaccharides on carbon tetrachloride-induced hepatocyte damage in common carp (Cyprinus carpio L.)

Liu, Ying-Juan; Du, Junbao; Cao, Liping; Jia, Rui; Shen, Yu-Jin; Zhao, Caiyuan; Pao, Xu; Yin, Guojun

doi:10.1016/j.intimp.2015.01.023

Cited by 89 publications

(39 citation statements)

References 33 publications

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“…Indeed, the WBC count is an indicator of immunosuppression, it is also another marker of nonspecific inflammation. The effect of GPS or CIS + GPS on suppressing WBC count is not relevant to immune organs protective effect possibly due to the anti‐inflammatory activity of GPS . The previous studies showed that tumor‐induced increased of WBC count, and anti‐inflammatory ingredients Brucea javanica Oil or the glycyrrhetinic acid modified curcumin‐loaded cationic liposomes could suppress WBC count.…”

Section: Discussionsupporting

confidence: 94%

“…In present research, the results showed that treatment CIS to U14‐bearing mice induced an obvious increase in the serum levels of AST, ALT, BUN, and CRE, indicating that acute liver and renal failure, which can be obviously ameliorated by GPS supplementary treatment. These findings are consistent with previous studies that G. lucidum fruiting bodies protects kidney and liver function …”

Section: Discussionsupporting

confidence: 94%

“…These findings are consistent with previous studies that G. lucidum fruiting bodies protects kidney and liver function. 27,34 In conclusion, the combined therapy of GPS and CIS indicates a better antitumor activity than GPS or CIS treatment alone in U14-bearing mice.…”

Section: Discussionmentioning

confidence: 85%

“…23 CD4 + T cells could activate and recruit innate immune cells including macrophages and natural killer cells in human antitumor immunity. 24 27 The previous studies showed that tumor-induced increased of WBC count, and anti-inflammatory ingredients Brucea javanica Oil or the glycyrrhetinic acid modified curcumin-loaded cationic liposomes could suppress WBC count. These findings were consistent with our results.…”

Section: Discussionmentioning

confidence: 99%

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Improved antitumor activity of cisplatin combined with Ganoderma lucidum polysaccharides in U14 cervical carcinoma‐bearing mice

Zhu

Jiang

et al. 2019

The Kaohsiung J of Med Scie

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Research on anticervical cancer is urgently required to enhance clinical outcomes. As a main anticancer drug for cervical carcinoma, cisplatin (CIS) has been used for a lot of years in clinical therapy. However, serious adverse effects including nephrotoxicity and neurotoxicity limit its long‐term treatment. Our main goal of this study is to investigate the improvement of Ganoderma lucidum polysaccharides (GPS) on CIS‐induced antitumor effect of in U14 cervical carcinoma‐bearing mice. The results showed that GPS + CIS could not only inhibit the growth of the tumor but also improve the spleen and thymus indexes. Moreover, little toxicological effects were observed on hepatic function and renal function in GPS + CIS treated mice bearing U14 tumor cells. Further analysis of the tumor inhibition mechanism indicated that the number of apoptotic tumor cells increased significantly, the expression of Bax increased and the expression of Bcl‐2 decreased dramatically in cervical cancer sections after oral administration of GPS + CIS for 14 days. This GPS/CIS combined therapy represents intriguing therapeutic strategy for U14 cervical carcinoma providing not only superior efficacy but also a higher safety level.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Improved antitumor activity of cisplatin combined with Ganoderma lucidum polysaccharides in U14 cervical carcinoma‐bearing mice

Zhu

Jiang

et al. 2019

The Kaohsiung J of Med Scie

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“…In recent years, many studies have reported that traditional herbal medicines and their extracts effectively inhibit hepatic pathologies[17]. CDAE has also been demonstrated to improve the hepatic injury induced by delayed-type hypersensitivity by inhibiting the immune response[18].…”

Section: Introductionmentioning

confidence: 99%

In vitroandin vivoantioxidative and hepatoprotective activity of aqueous extract of Cortex Dictamni

Lin

Zhou

Liu

et al. 2017

WJG

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AIMTo investigate the antioxidant and hepatoprotective effects of Cortex Dictamni aqueous extract (CDAE) in carbon tetrachloride (CCl4)-induced liver damage in rats.METHODSThe in vitro antioxidant effect of CDAE was investigated using α,α-diphenyl-β-picrylhydrazyl (DPPH), 2,2’-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), β-carotene bleaching, reducing power, and thiobarbituric acid reactive substance assays. A linoleic acid system, including ferric thiocyanate (FTC) and thiobarbituric acid (TBA) assays, was used to evaluate the inhibition of lipid peroxidation. The in vivo hepatoprotective and antioxidant effects of CDAE against CCl4-induced liver damage were evaluated in Sprague-Dawley rats. Silymarin was used as a positive control. Liver damage was assessed by determining hepatic histopathology and liver marker enzymes in serum. Enzyme and non-enzyme antioxidant levels and lipid peroxide content were measured in the liver. Cytochrome P450 2E1 (CYP2E1) protein expression was measured via immunohistochemical staining. Nuclear factor E2-related factor (Nrf2), heme oxygenase-1 (HO-1), NAD(P)H quinine oxidoreductase 1 (NQO1), and γ-glutamylcysteine synthetase catalytic subunit (γ-GCSc) protein expression was measured by Western blot.RESULTSOur results showed that CDAE exhibited a strong antioxidant activity in vitro. CDAE scavenged DPPH and ABTS radicals in a dose-dependent manner. CDAE inhibited lipid peroxidation with a lipid peroxide inhibition rate of 40.6% ± 5.2%. In the FTC and TBA assays, CDAE significantly inhibited lipid peroxidation (P < 0.01). In vivo histopathological studies indicated that CCl4-induced liver injury was alleviated following CDAE treatment in rats of both sexes. CDAE (160 and 320 mg/kg) significantly prevented CCl4-induced elevations of alkaline phosphatase, glutamate pyruvate transaminase, aspartate aminotransferase, and total bilirubin levels in rats of both sexes (P < 0.05, 0.01, or 0.001). Moreover, CDAE restored the decreased activities of hepatic antioxidant enzymes, including superoxide dismutase, catalase, and glutathione peroxidase, as well as non-enzyme antioxidant glutathione, which were induced by CCl4 treatment. CDAE significantly suppressed the up-regulation of CYP2E1 and promoted Nrf2, HO-1, NQO1, and γ-GCSc protein expression.CONCLUSIONCDAE exhibits good antioxidant performance in vitro, with marked radical-scavenging and anti-lipid peroxidation activities. CDAE is effective in preventing CCl4-induced hepatic damage in rats of both sexes. The hepatoprotective activity of CDAE may be attributable to its antioxidant activity, which may involve Keap1-Nrf2-mediated antioxidant regulation.

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Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties

Ahmad

Riaz

Khan

et al. 2021

Phytotherapy Research

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Reishi owes an exceptional value in nutritional, cosmeceutical, and medical treatments; however, none of the studies has provided its future-driven critical assessment. This study documents an up-to-date review (2015-2020, wherever applicable) and provide valuable insights (preclinical and clinical evidence-based) with comprehensive and critical assessments. Various databases 'Google scholar', 'Web of Science', 'ScienceDirect', 'PubMed', 'Springer Link', books, theses

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Anti-inflammatory and hepatoprotective effects of Ganoderma lucidum polysaccharides on carbon tetrachloride-induced hepatocyte damage in common carp (Cyprinus carpio L.)

Cited by 89 publications

References 33 publications

Improved antitumor activity of cisplatin combined with Ganoderma lucidum polysaccharides in U14 cervical carcinoma‐bearing mice

Improved antitumor activity of cisplatin combined with Ganoderma lucidum polysaccharides in U14 cervical carcinoma‐bearing mice

In vitroandin vivoantioxidative and hepatoprotective activity of aqueous extract of Cortex Dictamni

Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties

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