Anti-Inflammatory and Chemopreventive Effects of Triterpene Cinnamates and Acetates from Shea Fat

Abstract

Four triterpene acetates, α-amyrin acetate (1a), β-amyrin acetate (2a), lupeol acetate (3a), and butyrospermol acetate (4a), and four triterpene cinnamates, α -amyrin cinnamate (1c), β -amyrin cinnamate (2c), lupeol cinnamate (3c), and butyrospermol cinnamate (4c), were isolated from the kernel fat (n-hexane extract) of the shea tree (Vitellaria paradoxa; Sapotaceae). Upon evaluation of these eight triterpene esters for inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (

Phytochemical Studies of Ficus deltoidea var kunstleri

“…All the spectroscopic data are in good agreement with the reported literature values [4,[16][17][18][19][20][21][22]. …”

“…These data indicated that the compound 3 is a furanocoumarins; bergapten as characteristic signals unit were noticeable in both the NMR spectra. The identification of compound 3 as bergapten was confirmed by comparison of empirical data with published values [22].…”

Analgesic, Anti-Inflammatory and CNS Depressant Activities of Methanolic Extract of Sonneratia alba Leaves in Mice

“…Moreover, typically the study of locomotor exercise, as measured by gap cross and open industry tests, showed that ingredients of the leaves (200 mg/kg and 400 mg/kg) decreased the frequency and the amplitude of movements. Since, locomotor activity is actually a degree associated with the level of excitability in the CNS [26] this decrease inside spontaneous motor activity can be attributed to the sedative effect of the particular plant extracts [27,28]. In open field analyze, the dose of 400 mg/kg showed lowering effect inside locomotor activity in typically the first observation at (0 min) and continued upwards to a 2 nd observation period (30 min).…”

Triacylglycerol and Triterpene Ester Composition of Shea Nuts from Seven African Countries

“…Naturally occurring triterpene alcohols and their derivatives have numerous biologically useful proper-cently determined the contents and compositions of triterpene alcohol fractions from the NSL and fatty acid compositions of the kernel fats n-hexane extracts from 36 shea nut samples from 7 sub-Saharan countries 15 . Additionally, we have demonstrated that the cinnamyl 1c-4c and acetyl 1a-4a triterpene esters TEs , especially lupeol cinnamate 1c , that were isolated from the kernel fat, could be valuable as anti-infl ammatory agents and chemopreventive agents in chemical carcinogenesis 16 . We now report, in this paper, the contents and compositions of TAGs and TEs in the kernel fats of 36 shea nut samples from 7 sub-Saharan countries.…”

“…The shea kernel fats were fractionated by preparative-TLC into TE R f : 0.81 and TAG R f : 0.67 16 . The TAG fraction was subjected to HR-APCI-MS analysis on an LC/MSD TOF system using a Develosil C30-UG-3 as the LC column HPLC system II .…”